An observational study in White Matter Disease, Right-to-left Shunt and Migraine Disorders, sponsored by The First Hospital of Jilin University. Status unknown at 1 site in China. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-23.
Sponsored by The First Hospital of Jilin University · Observational
The purpose of the study is to evaluate the prevalence of white matter lesions in Chinese migraineurs with and without right-to-left shunt. The aim is to study the relationship among right-to-left shunt, migraine and white matter lesions.
This is a prospective multicenter study of Chinese population. Participants (normal individuals without migraine and migraineurs) are included after standardized diagnostic procedures (TCD and migraine diagnosis). For all the participants, brain MRI and c-TCD are required. Up to 10-15 study sites nationwide will be needed to recruit the planned participant population during a 1-year period.
The information of each participants will be registered, including basic facts, the longitudinal headache history, frequency, location, quality, intensity, duration, accompanied symptoms, precipitating and exacerbating factors, with or without aura, and Headache Impact Test-6 (HIT-6) questionnaire.
We detect RLS through contrast-enhanced transcranial Doppler (c-TCD). The normal individuals will be selected to group 1, while those who suffer from migraine will be selected to group 2. All the participants are required to take c-TCD and brain MRI.
healthy volunteers without a history of migraine were included as controls.
Exclusion Criteria:
Normal healthy individual without migraine.
Clinical history of migraine diagnosed by a neurologist according to the International Classification of Headache Disorders.
contrast-enhanced transcranial Doppler (c-TCD)
Brain MRI
Time frame: 1 year
Plan to share: Undecided
This study is status unknown, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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The First Hospital of Jilin University