Leukemia, Large Granular Lymphocytic clinical trials
The registry lists 144 studies for Leukemia, Large Granular Lymphocytic across more than 10 countries. 19 are recruiting or about to start. 17 of them are mainly about Leukemia, Large Granular Lymphocytic (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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· Enrollment: 300 → 450 participants
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Who runs them
National Cancer Institute (NCI) (16) · Fred Hutchinson Cancer Center (11) · Institute of Hematology & Blood Diseases Hospital, China (7) · M.D. Anderson Cancer Center (6) · Case Comprehensive Cancer Center (6) · Northwestern University (5) · European Organisation for Research and Treatment of Cancer - EORTC (4) · Memorial Sloan Kettering Cancer Center (4)
What is being tested here
Drugs under test in Leukemia, Large Granular Lymphocytic studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Methotrexate | 3 | 1 | 5 |
| Prednisone | 2 | 1 | 2 |
| Thalidomide | 2 | 1 | 2 |
| Cyclophosphamide | 1 | 1 | 7 |
| Etoposide | 1 | 1 | 5 |
| Ruxolitinib | 1 | 0 | 2 |
| Doxorubicin | 1 | 0 | 2 |
| Ifosfamide | 1 | 0 | 2 |
| Brentuximab Vedotin | 1 | 0 | 2 |
| Golidocitinib | 1 | 0 | 1 |
Drug classes tested here Antimetabolites 3 open · Tyrosine kinase inhibitors (TKIs) 3 open · JAK inhibitors 3 open · Corticosteroids 2 open · Alkylating agents 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026JAK1 Inhibitor Golidocitnib for the Treatment of Relapsed/Refractory Indolent T/NK-cell Lymphomas · Institute of Hematology & Blood Diseases Hospital, China
- Dec 2026A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas · Dren Bio
- Dec 2026Registry of the German CLL Study Group · German CLL Study Group
- Jul 2027Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic Leukemia · Jonathan Brammer
- Aug 2027A Study of Ruxolitinib and Duvelisib in People With Lymphoma · Memorial Sloan Kettering Cancer Center
Who these studies take
Of the 17 Leukemia, Large Granular Lymphocytic studies recruiting now, 13 (76%) set no upper age limit and 3 (18%) stop at 75 or younger. 4 (24%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (24%) | 4 (24%) |
| 18 | 16 (94%) | 16 (94%) |
| 30 | 16 (94%) | 16 (94%) |
| 40 | 15 (88%) | 15 (88%) |
| 50 | 15 (88%) | 15 (88%) |
| 65 | 16 (94%) | 16 (94%) |
| 75 | 14 (82%) | 14 (82%) |
| 85 | 14 (82%) | 14 (82%) |
Across all 144 studies, recruiting or not: 22% stop at 75 or younger and 13% at 65; 33% take children; 0% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 144. Browse all 144 → or search them.
- National Longitudinal Cohort of Hematological Diseases-Large Granular Lymphocytic LeukemiaRecruitingNCT070197661 country
- Golidocitinib in Patients With Mycosis Fungoides/Sézary Syndrome and T-Cell Large Granular Lymphocytic LeukemiaNot yet recruitingNCT07682792Phase 21 country
- A Clinical Study on the Efficacy and Safety of Zeprumetostat in Relapsed/Refractory Large Granular Lymphocyte LeukemiaRecruitingNCT07692529Phase 11 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- A Study of MDSY-1240, a STAT3 Degrader, for the Treatment of Hematologic Malignancies and Advanced Solid TumorsNot yet recruitingNCT07899632Phase 1/2
- Ruxolitinib for the Treatment of T-Cell Large Granular Lymphocytic LeukemiaRecruitingNCT05592015Phase 21 country
- Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/LymphomaRecruitingNCT03719105Early Phase 11 country
- Clinical and Biological Cohort Study of EBV-Positive T/NK-Cell Lymphoproliferative DiseasesRecruitingNCT077270831 country
- Registry of Older Patients With CancerRecruitingNCT011378251 country
- A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic LymphomasRecruitingNCT05475925Phase 1/29 countries
- A Registry for People With T-cell LymphomaRecruitingNCT059781411 country
- National Longitudinal Cohort of Hematological DiseasesRecruitingNCT046451991 country
- Registry of the German CLL Study GroupRecruitingNCT028636921 country
- Thalidomide for the Symptomatic Large Granular Lymphocytic LeukemiaRecruitingNCT06530576Phase 21 country
- JAK1 Inhibitor Golidocitnib for the Treatment of Relapsed/Refractory Indolent T/NK-cell LymphomasRecruitingNCT06716658Phase 21 country
- PI3K Inhibitors for the Treatment of Relapsed/Refractory Indolent T/NK-cell LymphomasRecruitingNCT06530550Phase 21 country
- Safety Evaluation Study for Patients With Aggressive NK-cell LeukemiaRecruitingNCT05863234Phase 1/21 country
- Clinical Study of Anti-CD56-CAR-T in the Treatment of Relapsed/Refractory NK/T Cell Lymphoma /NK Cell LeukemiaRecruitingNCT05941156Phase 21 country
- TPM Regimen (Thalidomide, Prednisone and Methotrexate) in LGLLRecruitingNCT04453345Phase 2/31 country
- A Study of Ruxolitinib and Duvelisib in People With LymphomaActive, not recruitingNCT05010005Phase 11 country
- Infection Prophylaxis and Management in Treating Cytomegalovirus (CMV) Infection in Patients With Hematologic Malignancies Previously Treated With Donor Stem Cell TransplantActive, not recruitingNCT011995621 country
- Oral Azacitidine for the Treatment of Relapsed or Refractory T-cell Large Granular Lymphocytic LeukemiaActive, not recruitingNCT05141682Phase 1/21 country
- TCRαβ-depleted Progenitor Cell Graft With Additional Memory T-cell DLI, Plus Selected Use of Blinatumomab, in Naive T-cell Depleted Haploidentical Donor Hematopoietc Cell Transplantation for Hematologic MalignanciesActive, not recruitingNCT03849651Phase 21 country
- 3'-Deoxy-3'-[18F] Fluorothymidine PET Imaging in Patients With CancerActive, not recruitingNCT009350901 country
- ABC008 in Subjects With T-cell Large Granular Lymphocytic Leukemia (T-LGLL)CompletedNCT05532722Phase 1/21 country
- A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological MalignanciesCompletedNCT01384513Phase 21 country
- Siltuximab in Large Granular Lymphocytic Leukemia (LGLL)TerminatedNCT05316116Early Phase 11 country
- Safety, PK, PD, Clinical Activity of KT-333 in Adult Patients With Refractory Lymphoma, Large Granular Lymphocytic Leukemia, Solid TumorsCompletedNCT05225584Phase 11 country
- Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (methotrexate, Cyclophosphamide) in Large Granular Lymphocytes LeukemiaCompletedNCT01976182Phase 21 country
- Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell TransplantCompletedNCT01588015Phase 11 country
- CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin LymphomaCompletedNCT02168140Phase 11 country
- Ipilimumab and Local Radiation for Selected Solid TumorsTerminatedNCT01769222Phase 11 country
- Methotrexate With or Without Cyclophosphamide in Treating Patients With Lymphocytic LeukemiaTerminatedNCT00003910Phase 21 country
- Collecting Tissue Samples From Patients With Leukemia or Other Blood Disorders Planning to Enroll in an ECOG Leukemia Treatment Clinical TrialCompletedNCT008977671 country
- Biological Therapy in Treating Patients at High-Risk or With Lymphoma, Lymphoproliferative Disease, or MalignanciesCompletedNCT00002663Phase 1/21 country
- Alemtuzumab (Campath) to Treat T-Large Granular Lymphocyte LeukemiaCompletedNCT00345345Phase 21 country
- Collecting and Storing Blood Samples From Patients With CancerWithdrawnNCT00900120
- Pemetrexed Disodium in the Cerebrospinal Fluid of Patients With Leptomeningeal MetastasesCompletedNCT00424242Early Phase 11 country
- Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ LymphomasTerminatedNCT01805037Phase 1/21 country
- Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic CancerCompletedNCT00003816Phase 2/31 country
- A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCLCompletedNCT03239392Phase 1/21 country
- Monoclonal Antibody Therapy Before Stem Cell Transplant in Treating Patients With Relapsed or Refractory Lymphoid MalignanciesTerminatedNCT01678443Phase 11 country
- Dasatinib for Immune Modulation After Donor Stem Cell Transplant for Hematologic MalignanciesTerminatedNCT01643603Phase 11 country
- Study of Akt Inhibitor MK2206 in Patients With Relapsed LymphomaCompletedNCT01258998Phase 21 country
- Methadone, Morphine, or Oxycodone in Treating Pain in Patients With CancerTerminatedNCT00726830Not applicable1 country
- Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a CatheterCompletedNCT00006083Phase 31 country
- Darbepoetin Alfa Compared With Epoetin Alfa in Treating Anemia in Patients Receiving Chemotherapy for CancerCompletedNCT00070382Phase 31 country
- Personalized Information or Basic Information in Helping Patients Make Decisions About Participating in a Clinical TrialCompletedNCT00750009Phase 31 country
- Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With Hematologic MalignanciesCompletedNCT00068523Not applicable1 country
- Treatment for Chronic Pain in Patients With Advanced CancerCompletedNCT00003687Phase 31 country