Hyperphosphatemia clinical trials
The registry lists 173 studies for Hyperphosphatemia across more than 10 countries. 16 are recruiting or about to start. 104 of them are mainly about Hyperphosphatemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Bayer (10) · Astellas Pharma Inc (8) · Kyowa Kirin Co., Ltd. (7) · Taisho Pharmaceutical Co., Ltd. (7) · Tanabe Pharma Corporation (7) · Ardelyx (6) · Genzyme, a Sanofi Company (6) · Keryx Biopharmaceuticals (6)
What is being tested here
Drugs under test in Hyperphosphatemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7, phase 3 first
- Nov 2026A Clinical Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis · Phase 3 · Taisho Pharmaceutical Co., Ltd.
- Dec 2026A Phase 3 Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis With Phosphate Binders · Phase 3 · Taisho Pharmaceutical Co., Ltd.
- May 2027A Clinical Study of TS-172 in Hyperphosphatemia Patients on Peritoneal Dialysis · Phase 3 · Taisho Pharmaceutical Co., Ltd.
- Jul 2027A Long-term Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis · Phase 3 · Taisho Pharmaceutical Co., Ltd.
- Nov 2026Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) · Duke University
- Feb 2027A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With Hyperphosphatemia · R1 Therapeutics
- Apr 2027Real-World Efficacy and Safety of Tenapanor Plus Phosphate Binders in Hemodialysis Patients With Hyperphosphatemia · Peking University People's Hospital
Who these studies take
Of the 13 Hyperphosphatemia studies recruiting now, 11 (85%) set no upper age limit and 2 (15%) stop at 75 or younger. 4 (31%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (23%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (23%) | 3 (23%) |
| 18 | 11 (85%) | 11 (85%) |
| 30 | 11 (85%) | 11 (85%) |
| 40 | 11 (85%) | 11 (85%) |
| 50 | 11 (85%) | 11 (85%) |
| 65 | 11 (85%) | 11 (85%) |
| 75 | 11 (85%) | 11 (85%) |
| 85 | 11 (85%) | 11 (85%) |
Across all 173 studies, recruiting or not: 17% stop at 75 or younger and 10% at 65; 14% take children; 0% are for women only and 1% for men only; 6% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperphosphatemia studies take
Of 21 phase 3 interventional studies under Hyperphosphatemia, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 7 mo6–10 · 13 studies | — | — |
| Phase 3 | 15 mo8–22 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered1
- Tenapanor in Maintenance Hemodialysis PatientsOct 20, 2026NCT07882017
Studies
Recruiting first, then most recently updated. Showing 50 of 173. Browse all 173 → or search them.
- Tenapanor in Maintenance Hemodialysis PatientsNot yet recruitingNCT078820171 country
- Multicenter, Open, Prospective, 48 Weeks, Observational Study ,Evaluate the Safety and Efficacy of Nephoxil CapsuleRecruitingNCT062061351 country
- Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)RecruitingNCT03573089Not applicable9 countries
- Phosphate in Acute PancreatitisRecruitingNCT07681050Phase 21 country
- A Study to Evaluate Safety, Tolerability and Efficacy of AP306 at Fixed Doses in Dialysis Participants With HyperphosphatemiaRecruitingNCT06712654Phase 22 countries
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)RecruitingNCT042784042 countries
- Real-World Efficacy and Safety of Tenapanor Plus Phosphate Binders in Hemodialysis Patients With HyperphosphatemiaNot yet recruitingNCT077761191 country
- A Clinical Study of TS-172 in Hyperphosphatemia Patients on Peritoneal DialysisRecruitingNCT07548853Phase 31 country
- A Phase 3 Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis With Phosphate BindersRecruitingNCT07285291Phase 31 country
- A Study of a Novel Iron-based Phosphate Binder AP301 in Patients With Hyperphosphatemia in the U.S. and ChinaRecruitingNCT06933472Phase 32 countries
- A Long-term Study of TS-172 in Hyperphosphatemia Patients on HemodialysisRecruitingNCT07285304Phase 31 country
- Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate MetabolismNot yet recruitingNCT068266641 country
- Evaluate the Efficacy and Safety of JMKX003002 in End-Stage Renal Disease Patients on Hemodialysis with HyperphosphatemiaRecruitingNCT06664125Phase 21 country
- Post Marketing Surveillance Study to Observe Safety and Effectiveness of NEPHOXIL ® in S. Korea PatientsRecruitingNCT061869341 country
- Chinese CKD-MBD Prevalence Survey (CRISS-MBD)RecruitingNCT047149181 country
- Improving Phosphate Control in Children With CKDRecruitingNCT054399801 country
- Study to Evaluate the Safety and Tolerability of Ferric Citrate in Children With Hyperphosphatemia Related to Chronic Kidney DiseaseSuspendedNCT04523727Phase 31 country
- A Clinical Study of TS-172 in Hyperphosphatemia Patients on HemodialysisActive, not recruitingNCT07548840Phase 31 country
- Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With HyperphosphatemiaCompletedNCT00772382Phase 32 countries
- A Study of MCI-196 in Chronic Kidney Disease Subjects on Dialysis With Hyperphosphatemia and DyslipidaemiaCompletedNCT00542386Phase 38 countries
- A Phase 3, Randomized, Double Blind, Placebo-Controlled, Multi-Center, Withdrawal Study of MCI-196 in CKD on Dialysis With HyperphosphatemiaCompletedNCT00506441Phase 32 countries
- A Phase III, Multicentre, Double-Blind, Placebo-Controlled Withdrawal Study in Patients With HyperphosphatemiaCompletedNCT00416520Phase 311 countries
- Drug-Drug Interaction Study to Evaluate the Effect of Colestilan on the Pharmacokinetics of Single Doses of Candesartan Cilexetil in Healthy SubjectsCompletedNCT01976572Phase 11 country
- A Study of MCI-196 in Chronic Kidney Disease Stage V Subjects on Dialysis With HyperphosphatemiaCompletedNCT00542815Phase 315 countries
- A Phase 3 Study of TS-172 in Hyperphosphatemia Patients on HemodialysisCompletedNCT06745531Phase 31 country
- AP301 Efficacy and Safety in Chinese Dialysis Patients With HyperphosphatemiaCompletedNCT07030595Phase 31 country
- Phosphate Diet Strategies to Lower Blood Phosphate in Dialysis PatientsCompletedNCT07180069Not applicable1 country
- Ferric Citrate for the Prevention of Renal Failure in Adults With Advanced Chronic Kidney DiseaseCompletedNCT05085275Phase 31 country
- A Phase 2 Study of TS-172 in Hyperphosphatemia Patients on Hemodialysis With Phosphate BindersCompletedNCT06745518Phase 21 country
- Phosphate Urine Excretion in Critically Ill PatientsActive, not recruitingNCT067793311 country
- A Phase 2 Dose-finding Study of TS-172 in Hyperphosphatemia Patients on HemodialysisCompletedNCT05699239Phase 21 country
- Single and Multiple Dosing Study in Hemodialysis Patients With Hyperphosphatemia in JapanCompletedNCT02510274Phase 11 country
- Efficacy and Safety of Cholestyramine in the Management of Hyperphosphatemia in Adult Hemodialysis PatientsCompletedNCT05577507Phase 41 country
- Explore the Effectors of The Transtheoretical Model on Nutritional Education in Patients on HemodialysisCompletedNCT05897502Not applicable1 country
- Ferric Citrate for the Treatment of Hyperphosphatemia in Patients With Chronic Kidney Disease Undergoing HemodialysisCompletedNCT04456803Phase 31 country
- Long-term Effects of the New Nordic Renal Diet in Patients With Moderate Chronic Kidney DiseaseCompletedNCT04579315Not applicable1 country
- Dose-finding Study of KHK7791 in Hyperphosphatemia PatientsCompletedNCT03864458Phase 21 country
- Phosphate Binder-combination Study of KHK7791 in Hyperphosphatemia PatientsCompletedNCT03864445Phase 21 country
- A Phosphate Binder Switch Study of KHK7791 in Hyperphosphatemia Patients on HDCompletedNCT03831607Phase 21 country
- A Study to Evaluate Safety and Efficacy of AP-306 in Hyperphosphatemia PatientsCompletedNCT05764590Phase 21 country
- Management of Mineral and Bone Disease in Hemodialysis-Calcitriol vs. ParicalcitolTerminatedNCT01725113Phase 41 country
- mHealth for Phosphorus Management in CKD.Active, not recruitingNCT05389826Not applicable1 country
- The Effect of Lanthanum Carbonate on Fibroblast Growth Factor 23 ( FGF23) in Chronic Kidney DiseaseCompletedNCT01002872Not applicable1 country
- Phosphate Binder Switch Study of KHK7791 in Hyperphosphatemia Patients on HemodialysisCompletedNCT04771780Phase 31 country
- A Phase 3 Study of Tenapanor to Treat Hyperphosphatemia in ESRD Patients on DialysisCompletedNCT03427125Phase 31 country
- A Study of Ferric Citrate to Improve Inflammation and Lipid LevelsTerminatedNCT02661295Phase 41 country
- Study to Evaluate the Use of Tenapanor as Core Therapy in the Treatment of HyperphosphatemiaCompletedNCT04549597Phase 41 country
- A Long-Term Study of Tenapanor Alone or in Combination With Sevelamer in Patients With CKD on Dialysis and HPCompletedNCT03988920Phase 41 country
- Study to Evaluate the Efficacy of Tenapanor as Adjunctive Therapy to Phosphate Binder TherapyCompletedNCT03824587Phase 2/31 country
- Auryxia (Ferric Citrate) Therapy for In-Center and Home Dialysis ParticipantsCompletedNCT04922645Phase 41 country