Hyperaldosteronism clinical trials
The registry lists 201 studies for Hyperaldosteronism across more than 10 countries. 93 are recruiting or about to start. 160 of them are mainly about Hyperaldosteronism (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Hyperaldosteronism studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Status
Who runs them
Chongqing Medical University (13) · Third Military Medical University (10) · Qifu Li (8) · University Hospital Padova (7) · National Taiwan University Hospital (6) · Changi General Hospital (6) · Chinese Academy of Medical Sciences, Fuwai Hospital (5) · Xinjiang Medical University (5)
What is being tested here
Drugs under test in Hyperaldosteronism studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Finerenone | 3 | 0 | 6 |
| Eplerenone | 2 | 0 | 5 |
| Amlodipine | 1 | 0 | 4 |
| Baxdrostat | 1 | 1 | 3 |
| Spironolactone | 1 | 0 | 2 |
| Fluorine-18 | 1 | 0 | 2 |
| SYH2072 | 1 | 0 | 1 |
| SAL0140 | 1 | 0 | 1 |
| QLS1410 | 1 | 0 | 1 |
| Gallium-68 | 1 | 0 | 1 |
Drug classes tested here Mineralocorticoid receptor antagonists (MRAs) 7 open · Calcium channel blockers 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jul 2027Parent Study: A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism Sub-study: A Follow-up Substudy After Completion of the BaxPA Main Study. · Phase 3 · AstraZeneca
- Nov 2026A Phase II Clinical Study on the Efficacy and Safety of HRS-1780 in Participants With Primary Aldosteronism · Shandong Suncadia Medicine Co., Ltd.
- Nov 2026Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) · Duke University
- Nov 2026Randomised Trial Comparing Thermal Ablation With Adrenalectomy in the Treatment of Unilateral Asymmetric PA · Queen Mary University of London
- Nov 2026The Effect of SAAE on Vascular Endothelial Function in PA Patients · Second Affiliated Hospital of Nanchang University
- Dec 2026China National Study of Adrenal Venous Sampling · Chinese Academy of Medical Sciences, Fuwai Hospital
- Dec 2026Steroids-Based Screening for Primary Aldosteronism · Qifu Li
- Dec 2026A Single Center Randomized Controlled Study on the Promotion of Rapid Recovery · Zhe Meng
- Dec 2026Effect of MRA on Cardiovascular Disease in Patients With Hypertension and Hyperaldosteronemia · Nanfang Li
- Dec 2026Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCT · Ruijin Hospital
Who these studies take
Of the 70 Hyperaldosteronism studies recruiting now, 23 (33%) set no upper age limit and 31 (44%) stop at 75 or younger. 7 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 14 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 5 (7%) | 5 (7%) |
| 18 | 62 (89%) | 62 (89%) |
| 30 | 67 (96%) | 67 (96%) |
| 40 | 68 (97%) | 68 (97%) |
| 50 | 68 (97%) | 68 (97%) |
| 65 | 62 (89%) | 62 (89%) |
| 75 | 47 (67%) | 47 (67%) |
| 85 | 30 (43%) | 30 (43%) |
Across all 201 studies, recruiting or not: 41% stop at 75 or younger and 14% at 65; 9% take children; <1% are for women only and <1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperaldosteronism studies take
Of 64 observational studies under Hyperaldosteronism, half reached primary completion within 75 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 36 mo21–59 · 35 studies | — | — |
| Observational | 75 mo32–96 · 64 studies | — | 75 mo32–96 · 64 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
Results posted1
Newly registered5
- Comparison of Sequential vs. Simultaneous Adrenal Vein SamplingNov 5, 2026NCT07918794
- Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena)Nov 5, 2026NCT07920198
- SYH2072 Tablets in Participants With Primary AldosteronismNov 4, 2026NCT07917039
- Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy VolunteersNov 3, 2026NCT07914075
- Comparing Inclisiran Versus Statin for Primary AldosteronismOct 21, 2026NCT07884955
Studies
Recruiting first, then most recently updated. Showing 50 of 201. Browse all 201 → or search them.
- 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT)RecruitingNCT06833437Not applicable1 country
- CHina Adrenal Venous saMPling InvestigatiONRecruitingNCT072522841 country
- Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena)RecruitingNCT079201981 country
- SYH2072 Tablets in Participants With Primary AldosteronismNot yet recruitingNCT07917039Phase 21 country
- Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA)RecruitingNCT07297745Not applicable1 country
- Kidney Stiffness Measured by Ultrasound in Patients With High Blood Pressure and Healthy VolunteersRecruitingNCT079140751 country
- Clinical and Molecular Characteristics of Primary Aldosteronism in BlacksRecruitingNCT033742151 country
- [11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept StudyRecruitingNCT07814105Not applicable1 country
- Evaluating the Functional Status of the Adrenal Glands With [68Ga]Ga-PentixaFor in Hyperaldosteronism and HypercortisolismRecruitingNCT06246357Phase 21 country
- Comparing Inclisiran Versus Statin for Primary AldosteronismRecruitingNCT07884955Not applicable1 country
- Cardiovascular Manifestations of MR Activation in Primary Aldosteronism: Pilot Clinical StudyRecruitingNCT05030545Phase 41 country
- SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive TherapyNot yet recruitingNCT07687160Phase 41 country
- Left-atrial Fibrosis in Persistent Atrial Fibrillation and Its ComorbiditiesRecruitingNCT078570441 country
- Intensive vs. Standard Blood Pressure Control in Primary AldosteronismRecruitingNCT07673445Not applicable1 country
- Diagnosing Variable Primary Aldosteronism.RecruitingNCT057657861 country
- Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary AldosteronismNot yet recruitingNCT07800858Not applicable1 country
- Regular Sauna Use to Lower Blood Pressure in Primary AldosteronismNot yet recruitingNCT07796048Not applicable
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)RecruitingNCT042784042 countries
- Early Aldo Blockade in Subclinical PANot yet recruitingNCT07727252Phase 2/3
- Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing AdenomaNot yet recruitingNCT07700472Not applicable1 country
- Study on the Application of Liquid Chromatography-Tandem Mass Spectrometry for the Determination of Aldosterone and Renin Activity in the Diagnosis of Primary Aldosteronism by Captopril TestRecruitingNCT076918011 country
- Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary AldosteronismRecruitingNCT07688928Not applicable1 country
- Biomarkers and Choroidal NeovascularizationRecruitingNCT044397081 country
- A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Primary AldosteronismNot yet recruitingNCT07646535Phase 21 country
- Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and HypertensionRecruitingNCT07470580Not applicable1 country
- Study on the Diagnostic Cut-off Point of 24-hour Urinary Aldosterone Measured by Liquid Chromatography-Tandem Mass Spectrometry in the Diagnosis of Primary Aldosteronism in the Oral Sodium Loading TestRecruitingNCT076351341 country
- Study on Cutoff Revision Effects and Evaluation of NNT in Primary AldosteronismRecruitingNCT076214581 country
- Diagnostic Value of 68Ga-Pentixafor PET/CT in Adrenal Tumors With Aldosterone and Cortisol CosecretionRecruitingNCT076051561 country
- Endoscopic Ultrasound-guided Radiofrequency Ablation in Primary AldosteronismRecruitingNCT05368090Not applicable1 country
- Adrenal Tumors - Pathogenesis and TherapyRecruitingNCT006692661 country
- Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol SecretionRecruitingNCT069552861 country
- Effects of Glucocorticoid Therapy on Renal Function in Patients With PA Complicated by CKD After Adrenalectomy: A Multicenter RCTNot yet recruitingNCT07558811Phase 4
- Steroids-Based Screening for Primary AldosteronismRecruitingNCT069411161 country
- Study of QLS1410 in the Treatment of Primary Aldosteronism.Not yet recruitingNCT07550465Phase 2
- REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility StudyRecruitingNCT06108427Not applicable1 country
- Virtual Twins as Tools for Personalized Clinical Care in Renal Denervation - Pilot StudyNot yet recruitingNCT074625721 country
- Prognosis of Primary Aldosteronism: A Prospective Cohort StudyRecruitingNCT073781761 country
- Genetic Predisposition to High Blood PressureEnrolling by invitationNCT07181213Not applicable1 country
- Superselective Adrenal Arterial Embolization Versus Oral Spironolactone for Treatment of Idiopathic HyperaldosteronismRecruitingNCT07328230Not applicable1 country
- The Association Between Primary Aldosteronism and Cognitive DysfunctionRecruitingNCT073046741 country
- Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE)RecruitingNCT07298954Not applicable1 country
- The Effect of SAAE on Vascular Endothelial Function in PA PatientsRecruitingNCT055613611 country
- Multi-omics Studies of Primary AldosteronismRecruitingNCT071113511 country
- Endoscopic Ultrasound-guided Radiofrequency Ablation for Upper Gastrointestinal Tract LesionsRecruitingNCT072721871 country
- Overnight Dexamethasone in Primary Aldosteronism ScreeningRecruitingNCT067408381 country
- Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal TumorsEnrolling by invitationNCT071821751 country
- Efficacy of Spironolactone Combined With Antihypertensive Drugs in Patients With Primary AldosteronismRecruitingNCT071373641 country
- Is the Evolution of the Aldosterone-renin Ratio Pre- Versus Post-operative on Day 1 Following Unilateral Adrenalectomy for Primary Hyperaldosteronism Predictive of Blood Pressure OutcomesNot yet recruitingNCT07110155
- PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary AldosteronismRecruitingNCT07027254Not applicable1 country
- Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to TreatRecruitingNCT065695891 country