Hydrocephalus clinical trials
The registry lists 190 studies for Hydrocephalus across more than 10 countries. 52 are recruiting or about to start. 128 of them are mainly about Hydrocephalus (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Hydrocephalus, Normal Pressure too: 247 studies, 67 open.
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Status
Who runs them
Rhaeos, Inc. (15) · Assiut University (5) · NeuroDx Development (5) · University of Utah (5) · Integra LifeSciences Corporation (5) · Johns Hopkins University (4) · CereVasc Inc (4) · University Hospital, Toulouse (4)
What is being tested here
Drugs under test in Hydrocephalus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Sirolimus | 2 | 0 | 2 |
| Vancomycin | 1 | 0 | 1 |
| Dexmedetomidine | 0 | 1 | 2 |
| Glucose | 0 | 1 | 1 |
| Isoflurane | 0 | 1 | 1 |
| Tissue Plasminogen Activator | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026CoMind Early Feasibility Study · CoMind Technologies Limited
- Nov 2026Study of Shunt Flow Under Different Valve Settings Using a Wireless Sensor · Rhaeos, Inc.
- Dec 2026NIRS Monitoring in Premature Infants · Boston Children's Hospital
- Dec 2026Ultrasound (US) Guided External Ventricular Catheter Placement · Milton S. Hershey Medical Center
- Dec 2026A Prospective Study Comparing CSF Shunt Flow Between "Virtual Off" and "Flow Permissive" Shunt Valve Settings Using a Wireless, Noninvasive Shunt Flow Sensor · Rhaeos, Inc.
- Dec 2026Flow Detection in Open and Closed Shunt Valve Periods · Rhaeos, Inc.
- Jan 2027MR Evaluation of Cerebrospinal Fluid (CSF) Dynamics · Mayo Clinic
- Jan 2027VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site · Rigshospitalet, Denmark
- Jan 2027EVD Drainage Data and Intracranial Pressure (ICP) Measurements · Baylor College of Medicine
- Mar 2027Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and Blood · Isabel Hostettler
Who these studies take
Of the 30 Hydrocephalus studies recruiting now, 17 (57%) set no upper age limit and 6 (20%) stop at 75 or younger. 14 (47%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 8 (27%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (37%) | 11 (37%) |
| 18 | 25 (83%) | 25 (83%) |
| 30 | 23 (77%) | 23 (77%) |
| 40 | 23 (77%) | 23 (77%) |
| 50 | 23 (77%) | 23 (77%) |
| 65 | 25 (83%) | 25 (83%) |
| 75 | 24 (80%) | 24 (80%) |
| 85 | 18 (60%) | 18 (60%) |
Across all 190 studies, recruiting or not: 33% stop at 75 or younger and 31% at 65; 55% take children; 2% are for women only and 0% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hydrocephalus studies take
Of 40 interventional studies with no phase under Hydrocephalus, half reached primary completion within 49 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 49 mo21–63 · 40 studies | — | — |
| Observational | 48 mo15–81 · 37 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Newly registered1
- Tissue Penetration of Paracetamol in Pediatric Intensive Care PatientsNov 4, 2026NCT07916831
Studies
Recruiting first, then most recently updated. Showing 50 of 190. Browse all 190 → or search them.
- Milk IntraNasal Therapy in Infants With Posthemorrhagic Ventricular Dilatation: A Safety and Feasibility StudyEnrolling by invitationNCT07928271Phase 1/21 country
- CEUS Evaluation of Hydrocephalus in Neonates and InfantsRecruitingNCT06693752Phase 21 country
- CoMind Early Feasibility StudyRecruitingNCT063686481 country
- Natural History of Treated Neurocysticercosis and Long-Term OutcomesRecruitingNCT000012051 country
- Expanded Access Protocol: Umbilical Cord Blood Infusions for Children With Brain InjuriesAvailableNCT033274671 country
- A Prospective Study Comparing CSF Shunt Flow Between "Virtual Off" and "Flow Permissive" Shunt Valve Settings Using a Wireless, Noninvasive Shunt Flow SensorNot yet recruitingNCT07815314Not applicable1 country
- Ultrasound and Photoacoustic Imaging of Hydrocephalus in Pediatric PatientsNot yet recruitingNCT07784179Not applicable
- Assessment of CSF Shunt Flow During Activities of Daily Living and Sleep With a Thermal Measurement DeviceRecruitingNCT07050628Not applicable1 country
- Cefazolin Antibiotic Prophylaxis in Ventricular Shunt Surgery: Determination of Cerebrospinal Fluid Concentration During Valve ImplantationRecruitingNCT07067736Not applicable1 country
- Bedside Cranial Ultrasound for Risk-Stratified Imaging in Pediatric Acute Brain InjuryNot yet recruitingNCT077723231 country
- Prophylactic Antibiotics Useful With Antibiotic Impregnated External Ventricular Drains (EVDs)?RecruitingNCT05001750Phase 11 country
- Efficacy of Combined Endoscopic Third Ventriculostomy and Choroid Plexus Cauterization in Treatment of HydrocephalusNot yet recruitingNCT07735936Not applicable1 country
- Role of Endoscopic Third Ventriculostomy Imanagement of Hydrocephalus in Pediatric Age Group; Clinical and Surgical OutcomeNot yet recruitingNCT07694518Not applicable1 country
- Study of Shunt Flow Under Different Valve Settings Using a Wireless SensorNot yet recruitingNCT07679035Not applicable1 country
- Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain HemorrhageNot yet recruitingNCT07662174Phase 1/21 country
- Ultrasound (US) Guided External Ventricular Catheter PlacementRecruitingNCT06253858Not applicable1 country
- Strategies for Weaning From External Ventricular DrainageNot yet recruitingNCT07630051Not applicable1 country
- UVC in Prevention of Surgical Wound InfectionNot yet recruitingNCT07600463Not applicable1 country
- HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)RecruitingNCT006707352 countries
- European Study of Prodromal iNPHRecruitingNCT059109443 countries
- Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different EtiologiesNot yet recruitingNCT07547826Phase 41 country
- CSF Protein Markers as Prognostic Indicators of the Response to CSF Shunt in Normotensive HydrocephalusRecruitingNCT059150001 country
- Neurosurgical Outcome NetworkRecruitingNCT067240291 country
- White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)RecruitingNCT071036811 country
- EVD Drainage Data and Intracranial Pressure (ICP) MeasurementsRecruitingNCT05546996Not applicable1 country
- NIRS Monitoring in Premature InfantsRecruitingNCT026013391 country
- Flow Detection in Open and Closed Shunt Valve PeriodsRecruitingNCT07478926Not applicable1 country
- Shunt-dependency After aSAH - Role of Early Hyperglycaemia in CSF and BloodRecruitingNCT064869091 country
- Simultaneous Vs Staged VPS and CP :A Multi-cnter RCT.Not yet recruitingNCT07462676Not applicable1 country
- Advanced MRI in IVHNot yet recruitingNCT07412886Not applicable1 country
- VentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling SiteRecruitingNCT073804771 country
- Safety and Performance of the Polaris® 24 Adjustable Valve System in Hydrocephalus Patients' TreatmentRecruitingNCT047466251 country
- MR Evaluation of Cerebrospinal Fluid (CSF) DynamicsRecruitingNCT04099823Not applicable1 country
- Non-Invasive Pressure Monitor for Neonates & Infants at Risk of Developing HydrocephalusEnrolling by invitationNCT06310213Not applicable1 country
- Light Therapy Device for Neonatal Intraventricular Hemorrhage Grade 3 and 4RecruitingNCT06797219Not applicable1 country
- Relationship Between Hydrocephalus and Endolymphatic HydropsNot yet recruitingNCT07003152
- Assessment of CSF Shunt Flow and Headaches With a Thermal Measurement DeviceRecruitingNCT06996600Not applicable1 country
- Assessment of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement Device in Asymptomatic PatientsNot yet recruitingNCT06410885Not applicable1 country
- Assessment of Flow in Cerebrospinal Fluid Shunts With a Second Generation Wireless Thermal Anisotropy Measurement DeviceNot yet recruitingNCT064092861 country
- Formative Usability Assessment of Wireless Thermal Anisotropy DevicesRecruitingNCT060406971 country
- Longitudinal Measurements of Flow in Cerebrospinal Fluid Shunts With a Wireless Thermal Anisotropy Measurement DeviceRecruitingNCT06086561Not applicable1 country
- Mechanisms of Brain-Heart Injury of Post-Intracranial HemorrhageRecruitingNCT069064321 country
- Bactiseal Catheter Safety Registry StudyRecruitingNCT062765431 country
- Late Post Traumatic Ventriculomegally Does It Requires CSF Diversion ?Not yet recruitingNCT06703164
- Insertion of Frontal Ventricular Catheter of VP Shunt in Congenital Hydrocephalus Guided by Trans Fontanelle UltrasoundNot yet recruitingNCT06664372Not applicable
- A Prospective Observational Study of Perioperative Lumbar Puncture Pressure and Shunt Valve Pressure Management in Patients with Communicating Hydrocephalus Undergoing Lumboperitoneal Shunt SurgeryRecruitingNCT066421291 country
- The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular HemorrhageRecruitingNCT06563817Phase 21 country
- VisAR Augmented Reality Navigation of VentriculostomyNot yet recruitingNCT06132139Not applicable
- Clinical Outcome in Patients With INPHRecruitingNCT064287341 country
- Impact of Hypnosis for Performing Lumbar Infusion TestsRecruitingNCT06419842Not applicable1 country