An interventional study of Cefazolin antibiotic prophylaxis in Hydrocephaly, CSF Shunts and Antibiotic Prophylaxis, sponsored by University Hospital, Strasbourg, France. Recruiting at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-08-20.
Sponsored by University Hospital, Strasbourg, France · Not applicable, Interventional, and Health services research
The objective is to determine the concentration of cefazolin in the cerebrospinal fluid after a recommended antiobiotic prophylaxis by 2g of cefazolin. Our main hypothesis is that the concentration is insufficient to protect the valve from infections.
The secondary objective is to compare our results to known pharmacokinetic models of cefazolin diffusion in the literature. If differences are found we would like to search clinical features that could explain it.
190 studies on the registry are indexed under Hydrocephalus; 52 are open to participants now.
This study's planned enrollment of 15 is below the median of 41 across 97 interventional studies indexed under Hydrocephalus.
Browse Hydrocephalus studies →University Hospital, Strasbourg, France is the lead sponsor of 999 studies on the registry; 358 are open to participants now.
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Age >18 years and programmed for a ventricular shunt surgery at the Hautepierre university hospital in Strasbourg.
Exclusion Criteria:
Other: Cefazolin antibiotic prophylaxis
Determination of cerebrospinal fluid concentration
Cefazolin concentration in the cerebrospinal fluid
Cefazolin concentration in the cerebrospinal fluid.
Time frame: The measure is made when the dura mater is opened just before the valve implantation.
blood cefazolin concentration
Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences.
Time frame: Blood samples are made before injection
blood cefazolin concentration
Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences.
Time frame: Blood samples are made 30 minutes , after injection
blood cefazolin concentration
Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences.
Time frame: Blood samples are made 1hour after injection
blood cefazolin concentration
Compare the cerebrospinal and blood cefazolin concentration to the known pharmacokinetic models in order to determine clinical features that could explain thoses differences.
Time frame: Blood samples are made 2 hours after injection
Plan to share: No
No publications or documents are linked to this record.
Started Feb 2026 (actual). Primary completion is estimated for Aug 2026, 6 months after the start.
Of 40 interventional studies with no phase under Hydrocephalus, half reached primary completion within 49 months of starting (the median), counting those still running; a quarter within 21 and three quarters within 63. This study's planned 6 months is below that.
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