Hydrocephalus, Normal Pressure clinical trials
The registry lists 78 studies for Hydrocephalus, Normal Pressure across more than 10 countries. 20 are recruiting or about to start. 68 of them are mainly about Hydrocephalus, Normal Pressure (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-05.
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Who runs them
Umeå University (7) · Johns Hopkins University (5) · CereVasc Inc (3) · Codman & Shurtleff (2) · Vanderbilt University Medical Center (2) · GE Healthcare (2) · University Hospital Hradec Kralove (2) · Linkoeping University (2)
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure Hydrocephalus · University of South Florida
- Dec 2026Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH) · Second Affiliated Hospital, School of Medicine, Zhejiang University
- Jan 2027Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus · CereVasc Inc
- Jan 2027Diagnostic Accuracy of ShuntCheck Compared to Radionuclide Shunt: Patency in Patients With Normal Pressure Hydrocephalus · University of South Florida
- Jun 2027Neurosurgical Outcome Network · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
- Sep 2027Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in Maryland · Johns Hopkins Bloomberg School of Public Health
- Oct 2027Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar Puncture · Assiut University
Who these studies take
Of the 16 Hydrocephalus, Normal Pressure studies recruiting now, 12 (75%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (19%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (13%) | 2 (13%) |
| 18 | 7 (44%) | 7 (44%) |
| 30 | 7 (44%) | 7 (44%) |
| 40 | 10 (63%) | 10 (63%) |
| 50 | 11 (69%) | 11 (69%) |
| 65 | 16 (100%) | 16 (100%) |
| 75 | 16 (100%) | 16 (100%) |
| 85 | 15 (94%) | 15 (94%) |
Across all 78 studies, recruiting or not: 1% stop at 75 or younger and 0% at 65; 12% take children; 0% are for women only and 0% for men only; 15% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hydrocephalus, Normal Pressure studies take
Of 21 interventional studies with no phase under Hydrocephalus, Normal Pressure, half reached primary completion within 41 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 41 mo34–75 · 21 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 78. Browse all 78 → or search them.
- Prediction of Response to Shunt Surgery in Normal Pressure Hydrocephalus Using Radscale and Lumbar PunctureNot yet recruitingNCT07832877
- Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure HydrocephalusRecruitingNCT07831044Not applicable1 country
- Examining the Feasibility of Using Pressure Gradient Regulated Automated Cerebral Spinal Fluid Drainage During External Lumbar Drain TrialsRecruitingNCT07494812Not applicable1 country
- Assessment of ShuntCheck Performance Characteristics in Asymptomatic Patients With Normal Pressure HydrocephalusRecruitingNCT040115661 country
- Diagnostic Accuracy of ShuntCheck Compared to Radionuclide Shunt: Patency in Patients With Normal Pressure HydrocephalusRecruitingNCT043094871 country
- Addressing Health Disparities in Normal Pressure Hydrocephalus (NPH) in MarylandNot yet recruitingNCT06426004Not applicable1 country
- European Study of Prodromal iNPHRecruitingNCT059109443 countries
- Transcranial Ultrasound Assessment of Cerebral Pulsatility in Shunt Decision-making for Suspected Idiopathic Normal Pressure Hydrocephalus: a Prospective Cohort StudyNot yet recruitingNCT072859281 country
- Multi-omics Research of Idopathic Normal Pressure Hydrocephalus (iNPH)RecruitingNCT04998175Not applicable1 country
- Normal Pressure Hydrocephalus and Sleep ApneaRecruitingNCT04471740Not applicable1 country
- CSF Protein Markers as Prognostic Indicators of the Response to CSF Shunt in Normotensive HydrocephalusRecruitingNCT059150001 country
- Neurosurgical Outcome NetworkRecruitingNCT067240291 country
- White Matter Distortion and Dementia Biomarkers in Normal Pressure Hydrocephalus (NPH)RecruitingNCT071036811 country
- Integrated Multimodal Assessment to Optimize Diagnosis and Surgical Selection in Idiopathic Normal Pressure HydrocephalusRecruitingNCT074278361 country
- Non-invasive Diagnostics of Shunt Obstruction in Adult HydrocephalusNot yet recruitingNCT07172841Not applicable
- Endoscopic Third Ventriculostomy vs. Ventriculoperitoneal Shunt in Idiopathic Normal Pressure Hydrocephalus (ENDOVEST)RecruitingNCT06488248Not applicable1 country
- Proteinopathies Expression in Skin of Neurodegenerative DisordersRecruitingNCT065289641 country
- Identifying Gait Changes From a CSF Tap Test Using a Smart Insole in iNPHRecruitingNCT067227681 country
- Study of Changes in CSF Ionic Composition After Aneurysmal Meningeal HemorrhageRecruitingNCT059427551 country
- Estimation of Intracranial Pressure Using Non-invasive Fundus VideosRecruitingNCT033828601 country
- The Effects of Exercise on Gait Characteristics, Balance, and Performance in Patients With Normal Pressure HydrocephalusCompletedNCT05679934Not applicable1 country
- Efficacy in iNPH Shunting (PENS) TrialCompletedNCT05081128Not applicable3 countries
- The Pilot Study of Medical Device-Neuclare for Patients With Idiopathic Normal Pressure Hydrocephalus (iNPH)CompletedNCT06478979Not applicable1 country
- Functional Outcomes After LumbOpenitoneal Shunt Placement UndeR Local Anesthesia for Patients With Idiopathic Normal preSsure Hydrocephalus (FLOURISH) TrialWithdrawnNCT07447479Phase 41 country
- Evaluation of the Safety and Effectiveness of the CereVasc® eShunt® System in Normal Pressure HydrocephalusActive, not recruitingNCT06498960Not applicable3 countries
- Flow MRI in Normal Pressure HydrocephalusCompletedNCT01909960Not applicable1 country
- Acetazolamide Trial in Normal Pressure HydrocephalusCompletedNCT04975269Phase 21 country
- Novel Parameters for the Prediction of Ventriculoperitoneal Shunting Efficacy in Patients With iNPHCompletedNCT02495610Not applicable1 country
- Pilot Study of the CereVasc® eShunt® System in Normal Pressure HydrocephalusActive, not recruitingNCT05250505Not applicable1 country
- Post Market Clinical Follow-up of CODMAN CERTAS Programmable ValveActive, not recruitingNCT053971064 countries
- The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPHCompletedNCT068571361 country
- Cerebrospinal Fluid Proteome in HydrocephalusCompletedNCT02016352Not applicable1 country
- Predictive Value of Flow MRI in Normal Pressure Hydrocephalus SurgeryCompletedNCT01815775Early Phase 11 country
- The Use of Q-Collar to Increase CSF Drainage in Low-pressure Hydrocephalus PatientsWithdrawnNCT06129565Not applicable
- US Pilot Study of the CereVasc® eShunt® System in Normal Pressure HydrocephalusActive, not recruitingNCT05232838Not applicable1 country
- A Pilot Biomarker Study Assessing Alpha-synuclein Aggregates Across Biofluid Reservoirs in Patients With SynucleinopathiesTerminatedNCT040201981 country
- Role of Brain Specific Biomarkers in HydrocephalusCompletedNCT060832331 country
- The Usage of Telemetric Prechamber Sensor Reservoir in Management of Normal Pressure Hydrocephalus. Comparisson of Benefit for Patients with Implanted Telemetric Prechamber Sensor Reservoir.CompletedNCT066291681 country
- Walking Pattern Characteristics in Normal Pressure HydrocephalusCompletedNCT04702035Not applicable1 country
- Volumetrics and Proteomics in Shunted Normal Pressure HydrocephalusActive, not recruitingNCT04785560Not applicable1 country
- CPT-3 in Normal Pressure HydrocephalusTerminatedNCT035215181 country
- Gait Pattern and Experienced Global Change After Shunt Surgery in Idiopathic Normal Pressure HydrocephalusStatus unknownNCT047950891 country
- MRI-Volumetry in the Evaluation of Shunt Treatment for HydrocephalusCompletedNCT04599153Not applicable1 country
- Normal Pressure Hydrocephalus Biomarkers InvestigationStatus unknownNCT055625961 country
- A Placebo-Controlled Effectiveness in INPH Shunting (PENS) TrialCompletedNCT03350750Not applicable3 countries
- Using Cerebrospinal Fluid Dynamics to Optimize Treatment of Idiopathic Normal Pressure HydrocephalusTerminatedNCT03076723Not applicable2 countries
- Prognostic Value of Aβ Imaging in NPH Prior to Shunt PlacementTerminatedNCT018346251 country
- CERTAS Programmable Valve RegistryCompletedNCT042072292 countries
- Ventriculomegaly and Gait Disturbance in the Senior Population in the Region of VästerbottenCompletedNCT052047451 country
- Neurology Inpatient Clinical Education TrialCompletedNCT03826056Not applicable1 country