Hookworm Infections clinical trials
The registry lists 39 studies for Hookworm Infections across more than 10 countries. 5 are recruiting or about to start. 20 of them are mainly about Hookworm Infections (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-08. Counting its narrower condition Ancylostomiasis too: 56 studies, 6 open.
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Who runs them
Baylor College of Medicine (11) · Jennifer Keiser (8) · Swiss Tropical & Public Health Institute (4) · Albert B. Sabin Vaccine Institute (3) · Johns Hopkins Bloomberg School of Public Health (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · PATH (1) · London School of Hygiene and Tropical Medicine (1)
What is being tested here
Drugs under test in Hookworm Infections studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Emodepside | 1 | 2 | 4 |
| Moxidectin | 1 | 3 | 4 |
| Albendazole | 0 | 2 | 5 |
| Ivermectin | 0 | 2 | 3 |
| Mebendazole | 0 | 0 | 3 |
| Oxfendazole | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2, phase 3 first
- Feb 2027Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras · Phase 3 · Mundo Sano Foundation
- Jun 2027Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections · Phase 3 · Swiss Tropical & Public Health Institute
Who these studies take
Of the 3 Hookworm Infections studies recruiting now, 1 (33%) set no upper age limit and 2 (67%) stop at 75 or younger. 2 (67%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (100%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (67%) | 2 (67%) |
| 18 | 2 (67%) | 2 (67%) |
| 30 | 2 (67%) | 2 (67%) |
| 40 | 2 (67%) | 2 (67%) |
| 50 | 1 (33%) | 1 (33%) |
| 65 | 1 (33%) | 1 (33%) |
| 75 | 1 (33%) | 1 (33%) |
| 85 | 1 (33%) | 1 (33%) |
Across all 39 studies, recruiting or not: 82% stop at 75 or younger and 82% at 65; 59% take children; 0% are for women only and 0% for men only; 59% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 39 of 39. search them.
- Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth InfectionsNot yet recruitingNCT06800248Phase 31 country
- Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in HondurasNot yet recruitingNCT07661316Phase 31 country
- Experimental Infection of Hookworm-naïve Adults With Dermally-applied Infectious Necator Americanus Hookworm LarvaeRecruitingNCT01940757Phase 11 country
- Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical DiseasesRecruitingNCT07145736Phase 41 country
- Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and EffectivenessRecruitingNCT06282315Phase 32 countries
- Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth InfectionsCompletedNCT06736691Phase 31 country
- Efficacy of Na-GST-1/Alhydrogel Hookworm Vaccine Assessed by Controlled Challenge InfectionCompletedNCT03172975Phase 21 country
- Efficacy, Safety and Acceptability of Ivermectin ODT in PSACCompletedNCT06184399Phase 21 country
- Efficacy and Safety of Moxidectin-Albendazole Co-administration in SACCompletedNCT06188715Phase 31 country
- Safety and Immunogenicity Study of Na-GST-1 With or Without CpGCompletedNCT02143518Phase 11 country
- Efficacy and Safety of Oxantel Pamoate in Children Infected With Trichuris TrichiuraCompletedNCT06720259Phase 21 country
- Evaluating Impact of Improved Floors on HealthCompletedNCT05914363Not applicable1 country
- Study of Co-administered Na-APR-1 (M74) and Na-GST-1 in Gabonese ChildrenCompletedNCT02839161Phase 11 country
- Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel AdjuvantCompletedNCT01385189Phase 11 country
- Efficacy and Safety of MOX/ALB vs. IVM/ALB Co-administrationCompletedNCT04700423Phase 2/31 country
- Efficacy and Safety of MOX/ALB Co-administrationCompletedNCT04726969Phase 31 country
- Efficacy and Safety of Emodepside in Adolescents and Adults Infected With HookwormCompletedNCT05538767Phase 21 country
- Albendazole Dose Finding and Pharmacokinetics in Children and AdultsCompletedNCT03527745Phase 21 country
- Efficacy and Safety of Emodepside in Adults Infected With Trichuris Trichiura and HookwormCompletedNCT05017194Phase 21 country
- Hookworm Immune Regulation ProjectStatus unknownNCT02262403Not applicable1 country
- Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese AdultsCompletedNCT03373214Phase 11 country
- Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against HookwormCompletedNCT03995680Phase 21 country
- Soil-transmitted Helminth Reinfection Rates After Single and Repeated School Hygiene EducationStatus unknownNCT04227834Not applicable1 country
- Study of Na-APR-1 (M74)/Alhydrogel® Co-administered With Na-GST-1/Alhydrogel in Brazilian AdultsCompletedNCT02476773Phase 11 country
- Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in AdultsWithdrawnNCT02636803Phase 2
- Safety and Immunogenicity of the Na-APR-1 Hookworm Vaccine in Healthy AdultsCompletedNCT01717950Phase 11 country
- Prevalence of Hookworm Infection and Community Preparedness for Hookworm Vaccine Trials in Endemic Areas of BrazilCompletedNCT00939198Not applicable1 country
- Triple Combinations Against Hookworm Infections in LaoCompletedNCT03278431Phase 41 country
- Mebendazole Study Against Hookworm Infections in Children and Adolescents in GhanaWithdrawnNCT03261596Phase 41 country
- Parasitic Infections of the Gastrointestinal TractTerminatedNCT000011621 country
- Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With or Without Additional Adjuvant in Brazilian AdultsCompletedNCT01261130Phase 11 country
- Study of Na-ASP-2 Human Hookworm Vaccine in Healthy Adults Without Evidence of Hookworm InfectionCompletedNCT00120081Phase 11 country
- Safety and Immunogenicity of Co-Administered Hookworm Vaccine Candidates Na-GST-1 and Na-APR-1 in Gabonese AdultsCompletedNCT02126462Phase 11 country
- Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or SchistosomaCompletedNCT01163877Not applicable1 country
- Efficacy of Albendazole to Treat Intestinal Helminths and Its Effect on Gut MicrofloraCompletedNCT01192802Phase 41 country
- Phase 1 Trial of Na-ASP-2 Hookworm Vaccine in Previously Infected Brazilian AdultsTerminatedNCT00473967Phase 11 country
- Development of a Skin Test for the Na-ASP-2 Hookworm AntigenCompletedNCT00603889Not applicable1 country
- Randomised Placebo Controlled Study of Effects of Therapeutic Hookworm Infection in AsthmaCompletedNCT00469989Not applicable1 country
- Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm InfectionsCompletedNCT00207753Not applicable1 country