Hand-Foot Syndrome clinical trials
The registry lists 43 studies for Hand-Foot Syndrome across more than 10 countries. 9 are recruiting or about to start. 31 of them are mainly about Hand-Foot Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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A study of drug A after surgery for early breast cancer
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· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Cyprus University of Technology (2) · Peking University Third Hospital (2) · M.D. Anderson Cancer Center (1) · Asan Medical Center (1) · University Hospital Tuebingen (1) · Emeishan Hospital of Traditional Chinese Medicine (1) · Advancell - Advanced In Vitro Cell Technologies, S.A. (1) · Li Zhihui (1)
What is being tested here
Drugs under test in Hand-Foot Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients · Erasmus Medical Center
- Mar 2027TAR-0520 Gel in Hand and Foot Syndrome · Tarian Pharma
- Jul 2027Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot Syndrome · Affiliated Hospital of Qinghai University
Who these studies take
Of the 5 Hand-Foot Syndrome studies recruiting now, 4 (80%) set no upper age limit and 0 (0%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 5 (100%) | 5 (100%) |
| 75 | 5 (100%) | 5 (100%) |
| 85 | 5 (100%) | 5 (100%) |
Across all 43 studies, recruiting or not: 19% stop at 75 or younger and 7% at 65; 2% take children; 12% are for women only and 0% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered2
- Oral Mecobalamin for TKI-Associated Hand-Foot Syndrome in Advanced Thyroid CancerNov 3, 2026NCT07911891
- Traditional Chinese Medicine Treatment for Capecitabine-Related Hand-Foot SyndromeOct 20, 2026NCT07883642
Studies
Recruiting first, then most recently updated. Showing 43 of 43. search them.
- Traditional Chinese Medicine Treatment for Capecitabine-Related Hand-Foot SyndromeNot yet recruitingNCT07883642Early Phase 1
- TAR-0520 Gel in Hand and Foot SyndromeNot yet recruitingNCT07457671Phase 21 country
- Traditional Chinese Medicine Hand-Foot Soak for Chemotherapy-Induced Peripheral Neuropathy and Hand-Foot SyndromeNot yet recruitingNCT07375446
- Impact of CES1 Genotype on Capecitabine Exposure in Cancer PatientsRecruitingNCT071146271 country
- Electroacupuncture Combined With Self-administered Acupressure for the Prevention of Capecitabine-Associated Hand-Foot SyndromeRecruitingNCT06602167Not applicable1 country
- The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI DrugsRecruitingNCT06583369Not applicable1 country
- The Preventive Effect of Chemotherapy-induced Hand-foot SyndromeRecruitingNCT06441513Not applicable1 country
- The Efficacy of Acupuncture and Laser Acupuncture in Treating Chemotherapy or Target Therapy-induced Hand-foot SyndromeNot yet recruitingNCT05949307Not applicable
- Photobiomodulation Therapy in the Management of Hand-foot Syndrome and Hand-foot Skin ReactionRecruitingNCT04979078Not applicable1 country
- Oral Mecobalamin for TKI-Associated Hand-Foot Syndrome in Advanced Thyroid CancerCompletedNCT07911891Phase 21 country
- Ice Plant Intensive Cream for the Prevention of Hand-Foot Syndrome in Breast Cancer: Pilot Randomized Controlled TrialCompletedNCT05755646Not applicable1 country
- The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot SyndromeActive, not recruitingNCT05165069Phase 31 country
- Efficacy and Safety of Moisturising Cream With or Without Vitamin E and Urea Cream in Palmar-plantar ErythrodysesthesiaCompletedNCT05939726Not applicable1 country
- Topical Diclofenac for Hand-Foot Syndrome Prevention in Colorectal and Gastric Cancer on Capecitabine (DICLO-HFS)CompletedNCT071775601 country
- Effectiveness of the Henna Application in Patients with Hand-Foot Syndrome: Nested Case-Control StudyCompletedNCT068325011 country
- Topical Cosmetic Products for Hand and Foot SyndromeCompletedNCT065860731 country
- Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With CapecitabineActive, not recruitingNCT06188000Not applicable1 country
- Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With CapecitabineCompletedNCT05641246Phase 21 country
- Vitamin B6 Can Prevent Hand and Foot Syndrome in Cancer Patients Capecitabine ChemotherapyTerminatedNCT00767689Not applicable1 country
- Acetylated Natural Nucleotides in Treating Hand-foot SyndromeCompletedNCT04592731Not applicable1 country
- Urea Cream Prevention for Capecitabine Associated Hand Foot SyndromeStatus unknownNCT05348278Phase 2/31 country
- Possible Protective Effect of Celecoxib Against Capecitabine Induced Hand and Foot Syndrome in Patients With Colorectal CancerStatus unknownNCT05327751Phase 31 country
- Hydration Based on Thoitaine, Aloe Vera and Calendula, in the Prevention of Hand-Foot Syndrome in Patients Using CapecitabineStatus unknownNCT04833998Phase 21 country
- Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast CancerTerminatedNCT00751101Phase 21 country
- Testing the Effectiveness of Henna on Managing PPECompletedNCT01751893Not applicable1 country
- Study of 0.1% Uracil Topical Cream (UTC) for the Prevention of Hand-Foot SyndromeCompletedNCT01100463Phase 1/21 country
- Efficacy of the Cosmetic Product "Onco-Repair" on Grade 2 Hand Foot SyndromeCompletedNCT03612011Phase 31 country
- Treatment of Hand and Foot Syndrome With Traditional Chinese Medicine Formula LC09 in Patients Who Are Receiving Capecitabine for Colorectal and/or Breast CancerCompletedNCT02794493Phase 3
- F511 Cream in Preventing Palmar-Plantar Erythrodysesthesia in Patients Receiving Doxorubicin Hydrochloride Liposome for Metastatic Breast CancerCompletedNCT00992706Phase 31 country
- The Effect of Topical Brimonidine Tartrate on Hand-foot Syndrome (HFS) in Cancer PatientsTerminatedNCT03173365Phase 21 country
- The Topical Application of Vitamin B6 in Palmar-Plantar ErythrodysesthesiaCompletedNCT02625415Not applicable1 country
- S-1 Versus Capecitabine in the First Line Treatment of MCC Patients.CompletedNCT01918852Phase 31 country
- Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast or Colorectal CancerTerminatedNCT00305643Phase 32 countries
- Topical Antiperspirant for Hand-Foot SyndromeCompletedNCT00213993Phase 21 country
- Pyridoxine in Preventing Hand-Foot Syndrome Caused by Capecitabine in Patients With CancerTerminatedNCT00486213Phase 31 country
- Topical Henna Preparation for the Treatment of Hand Foot Skin SyndromeWithdrawnNCT01097850Phase 2
- Effectiveness Allopurinol Topical Agent Prevention Capecitabine-induced Hand-foot SyndromeCompletedNCT01609166Phase 21 country
- Study of Pyridoxine for Hand-Foot SyndromeCompletedNCT00446147Phase 3
- Safety and Efficacy Placebo Controlled Study of ATH008 Cream in PPES Patients Secondary to CapecitabineCompletedNCT01316406Phase 24 countries
- Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine for Advanced Colorectal Cancer or Breast CancerStatus unknownNCT00559858Phase 31 country
- Treatment of Palmar Plantar Erythrodysesthesia (PPE) With Topical SildenafilCompletedNCT01219023Phase 11 country
- Prevention of Capecitabine Induced Hand and Foot SyndromeStatus unknownNCT01291628Not applicable1 country
- DOXIL for Consolidation Therapy in Ovarian Cancer.CompletedNCT00248248Phase 21 country