Glioblastoma: all 1,951 studies

Page 1 of 20. Open to participants first (457), then studies with results posted, then the rest; newest registration first within each.

• IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade AstrocytomasNot yet recruitingNCT07888647Phase 2
• Window of Opportunity Study of Lixumistat in Patients With Newly Diagnosed GlioblastomaRecruitingNCT07884344Early Phase 1
• Tris-CAR-T Cell Therapy Targeting CD44 and CD133 in Newly Diagnosed GlioblastomaNot yet recruitingNCT07873996Phase 2/3
• An Optimization Study Evaluating Safety and Efficacy of the Y-90 Glioblastoma (GBM) Device in Patients With Recurrent GBMNot yet recruitingNCT07867886Not applicable
• Diffuse Gliomas in Reunion Island: Establishment of an Epidemiological, Clinical-biological and Socio-anthropological CohorteRecruitingNCT07865195
• TMZ + RT + 5-ALA + LIDU SDT System for Newly Diagnosed Butterfly GliomaRecruitingNCT07862647Phase 1
• Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/GlioblastomaNot yet recruitingNCT07859059Phase 1/2
• GLAD-KE GLioma Biomarker and Safety Assessment During Dietary Ketone Elevation Subtitle: A Surgical Biomarker Discovery Study of Ketogenic Therapy in Recurrent GliomaNot yet recruitingNCT07852975Not applicable
• Metabolomics and Transcriptomics of Low- and High-Grade GliomasRecruitingNCT07832734
• REMIND Maintenance Radiotherapy for Newly Diagnosed GlioblastomaRecruitingNCT07831772Not applicable
• VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent GliomaRecruitingNCT07831369Phase 2
• Entacapone Plus Bevacizumab for Glioblastoma at First RecurrenceNot yet recruitingNCT07831187Phase 1/2
• Safety and Efficacy of Autologous Natural Killer Cell Therapy (CHANK-101) in Patients With Recurrent GlioblastomaNot yet recruitingNCT07831161Not applicable
• Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®Not yet recruitingNCT07821112Phase 2
• A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM CancersNot yet recruitingNCT07811297Phase 1/2
• FPS-ZM1 With or Without Dexamethasone for Controlling Post Operative Cerebral Edema in Patients With GlioblastomaNot yet recruitingNCT07791264Phase 1
• Adebrelimab Plus Temozolomide ± Hyperbaric Oxygen for Primary GlioblastomaNot yet recruitingNCT07789379Phase 2
• Impact of Pesticide Exposure on Survival and Tumor Aggressiveness in Patients With Glioblastoma: A Prospective Clinical StudyNot yet recruitingNCT07788430Not applicable
• Evaluation of the Distribution of 64Cu/68Ga Labeled CM500 in Healthy Volunteers and Patients With CancerNot yet recruitingNCT07781852Early Phase 1
• Safety and Feasibility of First-line Avutometinib and Defactinib in Patients With Newly Diagnosed High-grade GliomasNot yet recruitingNCT07778602Early Phase 1
• Tear Fluid for the Detection of Tumor-associated Extracellular Vesicles in Glioblastoma PatientsRecruitingNCT07775534Not applicable
• Hypoxia-targeted Radiotherapy Boost for GBMNot yet recruitingNCT07769918Not applicable
• Combination Immunotherapy Treatment for Glioblastoma Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 TherapyNot yet recruitingNCT07762716Phase 1/2
• Levetiracetam Extended-Release Plus Stupp Protocol for Hypoxic IDH-Wildtype GlioblastomaNot yet recruitingNCT07758062Phase 2
• STUPP Regimen With or Without Lenvatinib for Newly Diagnosed Glioblastoma With MGMT Promoter MethylationNot yet recruitingNCT07754734Phase 2
• Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade GliomaNot yet recruitingNCT07751744Phase 1/2
• NuvOx Expanded AccessAvailableNCT07748299
• OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed GlioblastomaNot yet recruitingNCT07739017Phase 1
• Positron Emission Tomography/Computed Tomography (PET/CT) Imaging in Patients Diagnosed With a GliomaNot yet recruitingNCT07735819Phase 2
• Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)RecruitingNCT07733674Phase 1
• Characterization of the Blood-Brain Barrier in High-Grade Glioma Through Immunohistochemical, Transcriptional, Fluorescein and Radiological AnalysesRecruitingNCT07731555Not applicable
• Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed GlioblastomaNot yet recruitingNCT07715097Phase 2
• Pilot Radioembolisation Clinical Trial Assessing Safety and Efficacy in Recurrent GliomaNot yet recruitingNCT07712770Early Phase 1
• Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype GlioblastomaRecruitingNCT07708961Phase 2
• ctDNA-Guided Intraventricular Therapy for CNS MalignanciesNot yet recruitingNCT07689721Not applicable
• Exploratory Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Tumor Neoantigen-pulsed Autologous Dendritic Cell Injection (YS247, Beijing YSCell Biotech Co., Ltd. [Abbreviated as YS])in Patients With Recurrent or Progressive GlioblastomaNot yet recruitingNCT07678138Not applicable
• Brain Radiotherapy Imaging for High-grade Glioma Using Hypoxia Targeting Through Oxygen-Enhanced ResponseNot yet recruitingNCT07670455Not applicable
• Intensified Adjuvant Therapy for High-Risk Newly Diagnosed Glioblastoma With Subtotal Resection or Short-Term ProgressionRecruitingNCT07670026Phase 2
• TTFields Plus FET-PET-Guided Stereotactic Radiosurgery Versus TTFields Alone for Recurrent Glioblastoma (Tarrget 2.0)RecruitingNCT07668869Not applicable
• Investigating the Feasibility and Acceptability of an Innovative Interdisciplinary Supportive Care Program: Couples Coping Together Against CancerRecruitingNCT07664579
• Dosimetry, Safety, and Efficacy Study of [177Lu]Lu-XT771 in Patients With Recurrent GlioblastomaRecruitingNCT07648823Early Phase 1
• Human ADME Study of [14C]-AZD1390Not yet recruitingNCT07643870Phase 1
• The EASE Study: Randomized Trial of a Novel Approach to Addressing Fear of Progression in Advanced CancerRecruitingNCT07636200Not applicable
• Triggered Imaging in Glioblastoma Based on Clinical Outcome Evaluation Compared to Routine: a Feasibility StudyEnrolling by invitationNCT07634575Not applicable
• Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-BeingNot yet recruitingNCT07628647Not applicable
• Cerebral Connectivity and Metabolic Phenotype of Gliomas: Prospective Addition of DTI and Rs-fMRI to a Preoperative FDG PET Strategy, With Neuropsychological Correlates and Post-treatment Follow-upNot yet recruitingNCT07628257Not applicable
• Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening: Advanced Brain Tumor TheRApy Clinical Trial In Patients Scheduled for shOrt Course radiatioNRecruitingNCT07627334Not applicable
• Laser Interstitial Thermal Therapy (LiTT) With Cemiplimab or Other Chemotherapy in Recurrent GlioblastomasNot yet recruitingNCT07620548Phase 2
• LITT for Ultra-early GBM RecurrenceRecruitingNCT07616986Not applicable
• Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis:RecruitingNCT07608003
• A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated GlioblastomaNot yet recruitingNCT07604285Phase 1/2
• PIRe 2.0: A Stepped-Care Model for Involving Relatives Across SectorsNot yet recruitingNCT07590726Not applicable
• A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent GlioblastomaRecruitingNCT07579208Phase 1
• Impact of Fluorescence-Guided Resection and Chemoradiotherapy on the Systemic Immune Response in Glioblastoma: A Kinetic Analysis of Immune Biomarkers.Not yet recruitingNCT07568782
• PET-Guided Resection in High-Grade GliomasRecruitingNCT07567196
• First-in Cancer-Type Phase I Study of FT536 for Recurrent WHO Grade 4 AstrocytomaRecruitingNCT07560865Phase 1
• Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant TumorsRecruitingNCT07552467
• NK Cell Therapy for Malignant Solid Brain TumorsRecruitingNCT07552233Not applicable
• Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade GliomaRecruitingNCT07551336Phase 1
• Efficacy of Zoster Vaccination in Glioblastoma PatientsNot yet recruitingNCT07546669Phase 4
• Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade GliomasRecruitingNCT07544992Phase 1
• Sitagliptin in Recurrent/Progressive Grade 4 GliomaRecruitingNCT07541781Phase 1
• Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent GlioblastomaRecruitingNCT07538128Early Phase 1
• APT-weighted and Diffusion MRI for Characterizing Tumor Infiltration in High-Grade GliomasNot yet recruitingNCT07532031
• Biomarker-Guided Dual-Target CAR-T Cells for Advanced Solid TumorsRecruitingNCT07523529Phase 1/2
• Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade GliomaNot yet recruitingNCT07521657Phase 2
• Oral Gallium Maltolate for Recurrent GlioblastomaNot yet recruitingNCT07515924Early Phase 1
• Precision Radiotherapy Enabled by Molecular MRIRecruitingNCT07512154Not applicable
• Prophylactic Regimen With Intrathecal Thiotepa in SVZ-positive or Meningeal-risk GlioblastomaRecruitingNCT07511725Phase 2
• A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of JL15003 Injection in Patients With Recurrent Glioblastoma (rGBM)RecruitingNCT07501559Phase 1/2
• Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical ProceduresRecruitingNCT07493447Early Phase 1
• Hypofractionated Radiotherapy Plus Temozolamide in Patients Younger Than 70 Years With GlioblastomaNot yet recruitingNCT07492836Not applicable
• Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) In Newly Diagnosed Glioma (WHO G3-G4)RecruitingNCT07488754Not applicable
• BGB-58067 in Newly Diagnosed Glioblastoma Patients With MTAP-Deleted TumorsRecruitingNCT07485049Early Phase 1
• Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade GliomaRecruitingNCT07480941Phase 1
• Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatomaRecruitingNCT07476794Phase 2
• Impact of Androgen Signaling on the Composition of the Immune Microenvironment in GlioblastomasNot yet recruitingNCT07472387Not applicable
• Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade GliomasRecruitingNCT07468136Phase 1/2
• A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade GliomaRecruitingNCT07464925Phase 1
• Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1RecruitingNCT07462507Phase 2
• Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma PatientsRecruitingNCT07461948Phase 3
• UNIty-Based MR-Linac Guided Adaptive RadioThErapy for High GraDe Glioma-4RecruitingNCT07459101Not applicable
• A Phase I Study of FZ-AD005 in Patients With High-Grade Glioma (HGG)Not yet recruitingNCT07455045Phase 1
• Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated GlioblastomaRecruitingNCT07452458Phase 3
• FCI-Glioblastoma StudyNot yet recruitingNCT07443176
• Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.RecruitingNCT07439172Phase 2
• A Phase 1b/2a Study to Evaluate the Safety, Pharmacokinetics, and Objective Response of STAR-001 (LP-184) in Combination With Spironolactone in Supratentorial Glioblastoma at First ProgressionNot yet recruitingNCT07431216Phase 1/2
• OT SMILE: Occupational Therapy Group Intervention for Primary Brain Tumour PatientsRecruitingNCT07426848Not applicable
• A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed GlioblastomaNot yet recruitingNCT07422896Phase 1
• Testing the Combination of Anti-cancer Drugs Actimab-A and Cemiplimab (REGN2810) to Improve Outcomes for Patients With Recurrent GlioblastomaNot yet recruitingNCT07422363Phase 1
• Liquid Biopsy in Glioblastoma Treated With Chemoradiation and an Oxygen TherapeuticEnrolling by invitationNCT07417774
• Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent GlioblastomaRecruitingNCT07416188Phase 1/2
• Comparison of Skin Closure Techniques in Oncological Neurosurgical Procedures: Intradermal Running Suture Versus Transdermal Interrupted SuturesRecruitingNCT07413796Not applicable
• Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial TumorsRecruitingNCT07411690
• EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid TumorsRecruitingNCT07410676Phase 1/2
• Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid TumorsRecruitingNCT07410494Phase 1/2
• Mental Health and Suicidality in Glioblastoma Patients in GermanyRecruitingNCT07409584
• Safety and Efficacy of CTX-009 With or Without CTX-471 for Recurrent GlioblastomaRecruitingNCT07392957Phase 1/2
• 5G-PEARL: Paxalisib in Malignant Brain TumoursRecruitingNCT07391215Phase 1/2
• Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG)Not yet recruitingNCT07389278Phase 1/2

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