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RecruitingNCT07865195GLIORUNUpdated Oct 8, 2026

Diffuse Gliomas in Reunion Island: Establishment of an Epidemiological, Clinical-biological and Socio-anthropological Cohorte

An observational study in Glioblastoma, sponsored by Centre Hospitalier Universitaire de la Réunion. Recruiting at 1 site in Reunion. Per ClinicalTrials.gov, last updated 2026-10-08.

Sponsored by Centre Hospitalier Universitaire de la Réunion · Observational

From the registry’s dates

  • Started Apr 2025; still recruiting 1 year 6 months later.
Updated Oct 8, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
214
Sex
All
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Study summary

To date, very little data exists on gliomas in the Réunion population, in terms of epidemiology, socio-cultural aspects, clinical or biological factors, and care pathways. However, the Réunion population is multicultural and highly cosmopolitan, experiencing rapid aging, and its socio-economic indicators are among the most pessimistic of all French departments. Furthermore, the healthcare services available on the island are less comprehensive than those in metropolitan France (Insee 2018). Finally, the management of patients with gliomas, particularly high-grade gliomas, remains very complex, with significant medical and social challenges (supportive care, end-of-life care, etc.). Healthcare professionals agree that these specialized facilities are insufficient to meet the care needs in Réunion (post-acute care, palliative care units, supportive care, etc.).

GlioRun is a retrospective and prospective mixed-methods cohort study, combining epidemiological and socio-anthropological approaches, which aims to produce data to improve care and the experiences of patients and their relatives on Reunion Island, and reduce the number of medical evacuations to mainland France.

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Conditions studied

  • Glioblastoma

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In context

Glioblastoma

1,920 studies on the registry are indexed under Glioblastoma; 450 are open to participants now.

This study's planned enrollment of 214 is above the median of 60 across 188 observational studies indexed under Glioblastoma.

Browse Glioblastoma studies →

Lead sponsor

Centre Hospitalier Universitaire de la Réunion is the lead sponsor of 138 studies on the registry; 36 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

person with glioma at La Réunion Island

Inclusion criteria

Quantitative study (retrospective and prospective components):

Patients aged 18 and over:

  • With a histological diagnosis of incident diffuse glioma since January 1, 2018
  • Residing in Réunion at the time of diagnosis,
  • Having been informed about the study procedures
  • Having agreed to participate in the study

Socio-anthropological study (prospective component):

Patients:

  • Meeting the inclusion criteria for the prospective quantitative study and agreeing to participate in the qualitative component,
  • Speaking French. • Able to participate in a face-to-face interview

Healthcare Professional:

  • Professionals involved in the care of patients with brain tumors (medical, paramedical, social care, support care, etc.) who have agreed to participate in the study
  • The healthcare professionals concerned will be general practitioners, neurosurgeons, neurologists, radiation oncologists, medical oncologists, home healthcare physicians, palliative care physicians, pathologists, nurses responsible for diagnosis and follow-up, psychologists, social workers, and dietitians.

Exclusion criteria

Exclusion Criteria:

Regarding the quantitative study:

Patient:

Refusing to participate in the quantitative study Having a recurrent diffuse glioma Person deprived of their liberty and judgment by judicial or administrative decision, and person subject to a legal protection measure: guardianship or curatorship, under judicial protection, under legal guardianship, etc.)

Regarding the socio-anthropological study:

Patient:

Refusing to participate in the qualitative study Does not speak French Having serious somatic or mental health problems incompatible with the interview Healthcare professionals: Refusing to participate in the study

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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
214 participants (estimated)
Patient registry
No
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What researchers measure

Primary outcomes

  1. Distribution of sociodemographic characteristics at diagnosis

    Distribution of age at diagnosis (years), sex (male/female), ethnicity, and socioeconomic indicators among patients diagnosed with diffuse glioma in Réunion Island

    Time frame: two years

Secondary outcomes

  1. Clinical presentation of diffuse gliomas at diagnosis

    Clinical characteristics at diagnosis including presenting symptoms, performance status (e.g., Karnofsky Performance Status score), tumor location, and initial treatment modalities

    Time frame: 2 years

  2. Molecular characteristics of diffuse gliomas

    Tumor molecular markers including IDH mutation status, 1p/19q codeletion status, and MGMT promoter methylation status assessed at diagnosis

    Time frame: inclusion

  3. Histopathological classification of diffuse gliomas

    Histopathological classification of tumors according to the WHO classification of central nervous system tumors at diagnosis

    Time frame: inclusion

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Study locations

1 of 1 sites recruiting
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References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

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Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 8, 2026
Show all 1 update
  1. Oct 8, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07865195
Lead sponsor
Centre Hospitalier Universitaire de la Réunion
Responsible party
Sponsor
First posted
Oct 8, 2026
Start date
Apr 7, 2025
Primary completion
Apr 7, 2028 (estimated)
Completion
Nov 7, 2028 (estimated)
Last update
Oct 8, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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