Giant Cell Arteritis clinical trials
The registry lists 147 studies for Giant Cell Arteritis across more than 10 countries. 49 are recruiting or about to start. 109 of them are mainly about Giant Cell Arteritis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-30.
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Status
Who runs them
Centre Hospitalier Universitaire Dijon (11) · University of Pennsylvania (7) · University of South Florida (5) · University of Bonn (5) · University of Oxford (4) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (4) · University Hospital, Brest (4) · University of Aarhus (4)
What is being tested here
Drugs under test in Giant Cell Arteritis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Tocilizumab | 2 | 3 | 12 |
| Abatacept | 2 | 2 | 4 |
| Bosentan | 2 | 0 | 2 |
| Hydrocortisone | 2 | 0 | 2 |
| Secukinumab | 1 | 2 | 5 |
| Prednisone | 1 | 3 | 4 |
| Methotrexate | 1 | 0 | 3 |
| Upadacitinib | 1 | 1 | 2 |
| Adalimumab | 1 | 1 | 2 |
| Infliximab | 1 | 0 | 2 |
Drug classes tested here Corticosteroids 3 open · Antimetabolites 1 open · JAK inhibitors 1 open · Tyrosine kinase inhibitors (TKIs) 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Dec 2026Performance of a Fast-track Pathway for Giant Cell Arteritis Diagnosis · Groupe Hospitalier de la Rochelle Ré Aunis
- Mar 2027The Applanation Tonometry in GCA Pilot · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
- Apr 2027Post-therapeutic Imaging Evaluation of Patients With Horton's Disease (Giant Cell Arteritis) (EvHortim) · Fondation Ophtalmologique Adolphe de Rothschild
- Jun 2027Impact of the Spatial Resolution of Several Contrast-enhanced 3D T1-WI Sequences When Diagnosing Giant Cell Arteritis (GCA) · Fondation Ophtalmologique Adolphe de Rothschild
- Jun 2027Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Controlled Giant Cell Arteritis · National Institute of Allergy and Infectious Diseases (NIAID)
- Jul 2027Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV) · University of Edinburgh
- Oct 2027Pilot Study to evaluateThrombomodulin to Rule Out Giant Cell Arteritis (GCA) in Polymyalgia Rheumatica (PMR) Patients. (THROPIQ) · Centre Hospitalier Universitaire Dijon
Who these studies take
Of the 36 Giant Cell Arteritis studies recruiting now, 34 (94%) set no upper age limit and 0 (0%) stop at 75 or younger. 4 (11%) take children under 18. 0 (0%) are for women only and 1 (3%) for men only; 9 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (11%) | 4 (11%) |
| 18 | 17 (47%) | 17 (47%) |
| 30 | 17 (47%) | 17 (47%) |
| 40 | 17 (47%) | 17 (47%) |
| 50 | 35 (97%) | 36 (100%) |
| 65 | 35 (97%) | 36 (100%) |
| 75 | 35 (97%) | 36 (100%) |
| 85 | 35 (97%) | 36 (100%) |
Across all 147 studies, recruiting or not: 1% stop at 75 or younger and 1% at 65; 10% take children; 0% are for women only and 1% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Giant Cell Arteritis studies take
Of 44 observational studies under Giant Cell Arteritis, half reached primary completion within 45 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 45 mo33–164 · 44 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCAOct 21, 2026NCT07508514
Newly registered1
- Aspirin for the Prevention of Ischemic Complications in Giant Cell ArteritisOct 30, 2026NCT07908082
Studies
Recruiting first, then most recently updated. Showing 50 of 147. Browse all 147 → or search them.
- Aspirin for the Prevention of Ischemic Complications in Giant Cell ArteritisNot yet recruitingNCT07908082Phase 31 country
- Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic VasculitisRecruitingNCT022578661 country
- Optic Nerve Sheath Ultrasound in Giant Cell ArteritisRecruitingNCT057490941 country
- Early Temporal Dynamics of Optic Nerve Sheath Diameter After Therapy in GCARecruitingNCT075085141 country
- Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study.Not yet recruitingNCT07628075Not applicable1 country
- Vascular MRI Evaluation in Giant Cell Arteritis (VEGA)RecruitingNCT058650543 countries
- Disease Activity Monitoring in Patients With Giant Cell Arteritis StudyRecruitingNCT075526361 country
- Abatacept for the Treatment of Giant Cell ArteritisRecruitingNCT04474847Phase 33 countries
- Expanded Access to UpadacitinibAvailableNCT04159597
- Inflammatory Disease Biobank for Immunophenotyping and Cardiovascular ResearchNot yet recruitingNCT07737470
- Tocilizumab Discontinuation Versus Dose Reduction for Patients With Well-Controlled Giant Cell ArteritisRecruitingNCT07108387Phase 21 country
- Kinetics of C-Reactive Protein in Giant Cell Arteritis Following Glucocorticoid Initiation: A Pilot Study (GIDEON)Not yet recruitingNCT07720804Not applicable
- Halo Sign Vanishing Time After Steroids Outbreak in GCA PatientsRecruitingNCT07060274Not applicable1 country
- Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder ArthroplastyRecruitingNCT07138898Phase 21 country
- Giant Cell Arteritis: Comparison Between Two Standardized Corticosteroids TaperingRecruitingNCT04012905Phase 31 country
- Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA)Not yet recruitingNCT072699381 country
- Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell ArteritisRecruitingNCT072062381 country
- Bosentan in the Treatment of Giant Cell ArteritisNot yet recruitingNCT06957002Phase 21 country
- A Clinical Trial to Investigate 18F-AzaFol in the Diagnosis of Large Vessel VasculitisRecruitingNCT06335888Phase 21 country
- Treatment for Giant Cell Arteritis With Tocilizumab and 8 as Compared to 26 Weeks of PrednisoneNot yet recruitingNCT06833411Phase 31 country
- The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis.RecruitingNCT072465771 country
- Association of Ultrasonographic Temporal Artery Lesions and Relapse in Patients With Giant Cell ArteritisRecruitingNCT068946021 country
- Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal InsufficiencyRecruitingNCT05435781Phase 41 country
- Rheumatology Patient Registry and BiorepositoryRecruitingNCT044020861 country
- Study of the Association Between Sacroiliitis/Axial Spondylarthritis and Giant Cell Arteritis/ Polymyalgia RheumaticaNot yet recruitingNCT073944781 country
- One-Time DNA Study for VasculitisRecruitingNCT012413053 countries
- VCRC Tissue RepositoryRecruitingNCT029670682 countries
- Upadacitinib in Giant Cell Arteritis (GCA) With Active Large-vessel Involvement.Not yet recruitingNCT073549061 country
- Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)RecruitingNCT06887062Phase 21 country
- Impact of the Spatial Resolution of Several Contrast-enhanced 3D T1-WI Sequences When Diagnosing Giant Cell Arteritis (GCA)RecruitingNCT058549271 country
- Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid TreatmentRecruitingNCT05193396Phase 41 country
- Giant Cell Arteritis - Ways to Precision MedicineRecruitingNCT070844801 country
- oPtic Nerve Sheath Evaluation in gianT Cell aRtheritis by UltraSoundRecruitingNCT07001059Not applicable1 country
- Pilot Study to evaluateThrombomodulin to Rule Out Giant Cell Arteritis (GCA) in Polymyalgia Rheumatica (PMR) Patients. (THROPIQ)RecruitingNCT066096681 country
- Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and EfficacyRecruitingNCT071500001 country
- Performance of a Fast-track Pathway for Giant Cell Arteritis DiagnosisRecruitingNCT067426711 country
- AYLo - AutoimmunitY and Loss of yRecruitingNCT066960271 country
- Assessing Biomarker in Giant Cell Arteritis and Polymyalgia RheumaticRecruitingNCT064601421 country
- Armenian NAtionwide REGistry of Systemic Autoimmune and Autoinflammatory DiseasesRecruitingNCT059043011 country
- Predictive Factors for Treatment Response in Patients With Newly-diagnosed Polymyalgia Rheumatica and Giant Cell ArteritisRecruitingNCT054794481 country
- Clinical and Immunogenetic Characterization of Giant Cell Arteritis (GCA) and Polymyalgia Rheumatica (PMR)RecruitingNCT041029301 country
- Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic DiseasesEnrolling by invitationNCT06763783Phase 41 country
- A Registry Study Assessing PRO, Dosing Patterns, and Safety of Vunakizumab in Patients With General Rheumatic Diseases.Not yet recruitingNCT067665521 country
- TocILizumab in aorTitis in GCA (TILT)RecruitingNCT062710181 country
- Visual Involvement in Giant Cell ArteritisRecruitingNCT065007281 country
- Post-therapeutic Imaging Evaluation of Patients With Horton's Disease (Giant Cell Arteritis) (EvHortim)RecruitingNCT060041541 country
- Investigation of the Influence of the Human Microbiome on Giant Cell ArteritisRecruitingNCT062790651 country
- Clonal Hematopoiesis in Giant Cell ArteritisNot yet recruitingNCT06244069
- DANIsh VASculitis Database (DANIVAS)RecruitingNCT059357091 country
- MEthotrexate Versus TOcilizumab for Treatment of GIant Cell Arteritis: a Multicenter, Randomized, Controlled TrialCompletedNCT03892785Phase 31 country