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Fragile X Syndrome clinical trials

The registry lists 115 studies for Fragile X Syndrome across more than 10 countries. 25 are recruiting or about to start. 90 of them are mainly about Fragile X Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed
67
Recruiting
18
Terminated
7
Status unknown
6
Not yet recruiting
5
Active, not recruiting
5

Phase

Phase 2
49
Phase 1
16
Phase 3
13
Phase 4
4
Early Phase 1
1

Where

United States
82
Spain
14
France
13
Canada
12
United Kingdom
8
Italy
8

Who runs them

Seaside Therapeutics, Inc. (9) · Children's Hospital Medical Center, Cincinnati (8) · Stanford University (7) · University of California, Davis (6) · Novartis Pharmaceuticals (6) · Université de Sherbrooke (4) · Tetra Discovery Partners (4) · Connecta Therapeutics, S.L. (3)

What is being tested here

Drugs under test in Fragile X Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Methylphenidate202
Cannabidiol202
Sertraline102
SRX246101
Fluoxetine101
Risperidone101
Mavoglurant016
Metformin015
Arbaclofen035
BPN14770034

Drug classes tested here SSRIs 2 open

Coming up

3phase 3 studies under way
11studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 18 Fragile X Syndrome studies recruiting now, 5 (28%) set no upper age limit and 13 (72%) stop at 75 or younger. 15 (83%) take children under 18. 1 (6%) are for women only and 3 (17%) for men only; 7 (39%) take healthy volunteers.

Recruiting studies that take each age, of 18
AgeWomenMen
1010 (56%)11 (61%)
1810 (56%)12 (67%)
307 (39%)9 (50%)
407 (39%)9 (50%)
506 (33%)6 (33%)
654 (22%)4 (22%)
754 (22%)4 (22%)
854 (22%)4 (22%)

Across all 115 studies, recruiting or not: 84% stop at 75 or younger and 84% at 65; 70% take children; 3% are for women only and 23% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Fragile X Syndrome studies take

Of 15 phase 2 interventional studies under Fragile X Syndrome, half reached primary completion within 24 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Phase 224 mo15–37 · 15 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 15, 2026.

Newly registered2

Studies

Recruiting first, then most recently updated. Showing 50 of 115. Browse all 115 → or search them.