Desmoid Tumors clinical trials
The registry lists 71 studies for Desmoid Tumors across more than 10 countries. 21 are recruiting or about to start. 48 of them are mainly about Desmoid Tumors (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Children's Oncology Group (7) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (5) · Istituto Ortopedico Rizzoli (5) · National Cancer Institute (NCI) (4) · SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany (4) · University Hospital, Strasbourg, France (3) · Centre Oscar Lambret (2) · Memorial Sloan Kettering Cancer Center (2)
What is being tested here
Drugs under test in Desmoid Tumors studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Nirogacestat | 2 | 1 | 6 |
| Tegavivint | 1 | 0 | 2 |
| Anti-CD39 Antibody/TGF-beta RII Ectodomain Fusion Protein ES014 | 1 | 0 | 1 |
| Anlotinib | 1 | 0 | 1 |
| Imatinib | 0 | 0 | 2 |
| Toremifene | 0 | 0 | 2 |
| Ipilimumab | 0 | 0 | 1 |
| Nivolumab | 0 | 0 | 1 |
| BMS-986115 | 0 | 1 | 1 |
| E-7386 | 0 | 0 | 1 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 1 open · SERMs 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Dec 2026HIFU Ablation of Soft Tissue Sarcoma · Oxford University Hospitals NHS Trust
- Jan 2027Cryotherapy in the Treatment of Desmoid Tumors · Istituto Ortopedico Rizzoli
- Feb 2027Arterial Chemoembolization for the Treatment of Desmoid Fibromatosis · Istituto Ortopedico Rizzoli
- Feb 2027Observing People With Desmoid-Type Fibromatosis · Memorial Sloan Kettering Cancer Center
- Mar 2027Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting · University Hospital, Strasbourg, France
- Mar 2027A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC) · Eisai Co., Ltd.
- Apr 2027FOG-001 in Locally Advanced or Metastatic Solid Tumors · Parabilis Medicines, Inc.
- May 2027A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) · SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
Who these studies take
Of the 17 Desmoid Tumors studies recruiting now, 13 (76%) set no upper age limit and 4 (24%) stop at 75 or younger. 6 (35%) take children under 18. 1 (6%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (24%) | 4 (24%) |
| 18 | 17 (100%) | 16 (94%) |
| 30 | 16 (94%) | 15 (88%) |
| 40 | 15 (88%) | 14 (82%) |
| 50 | 14 (82%) | 14 (82%) |
| 65 | 14 (82%) | 14 (82%) |
| 75 | 13 (76%) | 13 (76%) |
| 85 | 13 (76%) | 13 (76%) |
Across all 71 studies, recruiting or not: 23% stop at 75 or younger and 18% at 65; 41% take children; 3% are for women only and 0% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 71. Browse all 71 → or search them.
- Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)RecruitingNCT07176689Phase 46 countries
- A Study in Adults With Desmoid TumorsRecruitingNCT07541430Phase 21 country
- FOG-001 in Locally Advanced or Metastatic Solid TumorsRecruitingNCT05919264Phase 1/22 countries
- Individual Patient Compassionate Use of NirogacestatAvailableNCT050410362 countries
- Patient-reported Outcomes Following Percutaneous Ablation of Desmoid TumorsEnrolling by invitationNCT077551761 country
- Study of Cryoablation and Nirogacestat for Desmoid TumorRecruitingNCT05949099Phase 21 country
- Project: Every Child for Younger Patients With CancerRecruitingNCT024022446 countries
- Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid TumorsRecruitingNCT04851119Phase 1/21 country
- A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP).Not yet recruitingNCT07729371Phase 1
- Observing People With Desmoid-Type FibromatosisRecruitingNCT042813811 country
- Arterial Chemoembolization for the Treatment of Desmoid FibromatosisRecruitingNCT062684571 country
- Radiomics Compared With Conventional Response Criteria for Predicting Progression of Desmoid Tumor After CryoablationRecruitingNCT062242831 country
- Immunological Phenotype of Desmoid-fibromatosis-affected Patients.RecruitingNCT074962422 countries
- HIFU Ablation of Soft Tissue SarcomaRecruitingNCT05111964Not applicable1 country
- Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful WaitingRecruitingNCT06081400Not applicable1 country
- Treatment of Desmoid Fibromatosis With Arterial EmbolizationRecruitingNCT069458871 country
- Cryotherapy in the Treatment of Desmoid TumorsRecruitingNCT05091255Not applicable1 country
- A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid TumorsNot yet recruitingNCT06355921Not applicable1 country
- Clinicopathological Features and Molecular Typing of Invasive Fibroma of Abdominal WallRecruitingNCT062041981 country
- Clinical Study of Anlotinib Combined With Chemotherapy in the Treatment of Unresectable Advanced Desmoid TumorRecruitingNCT05490667Not applicable1 country
- Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids TumorsRecruitingNCT01898416Phase 21 country
- A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by SurgeryActive, not recruitingNCT04195399Phase 25 countries
- Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib MesylateCompletedNCT01046487Phase 11 country
- A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF)Active, not recruitingNCT07170644Phase 21 country
- Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)CompletedNCT03785964Phase 37 countries
- Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive FibromatosisCompletedNCT02066181Phase 32 countries
- Nivolumab and Ipilimumab in Treating Patients With Rare TumorsActive, not recruitingNCT02834013Phase 22 countries
- A Study of AL102 in Patients With Progressing Desmoid TumorsActive, not recruitingNCT04871282Phase 2/311 countries
- Electrochemotherapy for Desmoid TumorsWithdrawnNCT066601211 country
- PRISM for Depression and Anxiety in Young Adults With CancerCompletedNCT06502483Not applicable1 country
- National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis (ALTITUDES)Active, not recruitingNCT02867033Not applicable1 country
- Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)Active, not recruitingNCT074612461 country
- A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC)Active, not recruitingNCT03833700Phase 11 country
- Evaluation of the Cryodestruction of Non Abdominopelvic Desmoid Tumors in Patients Progressing Despite Medical TreatmentCompletedNCT02476305Not applicable1 country
- Endoxifen in Adults With Hormone Receptor Positive Solid TumorsCompletedNCT01273168Phase 11 country
- Tailored Beta-catenin Mutational Approach in Extra-abdominal Sporadic Desmoids Tumor PatientsCompletedNCT025478311 country
- PAZOPANIB Efficacy and Tolerance in Desmoids TumorsCompletedNCT01876082Phase 21 country
- Burden of Disease and Living Situation in Desmoid PatientsCompletedNCT062584211 country
- RCT of Two Noncrosslinked Porcine Acellular Dermal Matrices in Ab Wall ReconstructionCompletedNCT02228889Not applicable1 country
- Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain CancersCompletedNCT03190174Phase 1/21 country
- MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid TumorsCompletedNCT02076906Phase 11 country
- A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid TumorCompletedNCT03802084Phase 1/21 country
- Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive FibromatosisCompletedNCT01981551Phase 21 country
- CT-guided Radioactive Iodine-125 Seed Implantation for Recurrent Desmoid TumorsCompletedNCT061950851 country
- Cryoablation for Advanced and Refractory Desmoid TumorsStatus unknownNCT061130941 country
- Imatinib in Patients With Desmoid Tumor and ChondrosarcomaCompletedNCT00928525Phase 21 country
- Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue SarcomaCompletedNCT009192697 countries
- Quality of Life of Patients With Desmoid-type FibromatosisCompletedNCT042890772 countries
- A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type FibromatosisCompletedNCT01265030Phase 1/21 country
- Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059CompletedNCT03459469Phase 12 countries