Depressive Disorder, Treatment-Resistant: all 472 studies

Page 2 of 5. Open to participants first (151), then studies with results posted, then the rest; newest registration first within each.

• Transcranial Ultrasonic Stimulation in Treatment-resistant Depression : an Open-label Pilot TrialRecruitingNCT06085950Not applicable
• Positron Emission Tomography in Transcranial Magnetic Stimulation Intervention for Treatment-resistant DepressionEnrolling by invitationNCT06044324Not applicable
• pBFS Guided rTMS Therapy Over Different Targets for Treatment-Resistant DepressionRecruitingNCT05976022Not applicable
• pBFS-Guided rTMS Therapy Over Different Targets for Treatment-Resistant DepressionRecruitingNCT05976009Not applicable
• The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.RecruitingNCT05973851Phase 3
• Treatment Resistant Depression and Vagus Nerve StimulationRecruitingNCT05952674Not applicable
• pBFS Guided rTMS Over DMPFC for Treatment-Resistant DepressionRecruitingNCT05948839Not applicable
• Disruptions of Brain Networks and Sleep by Electroconvulsive TherapyRecruitingNCT05905705
• Dutch-Depression Outcome Trial Comparing 5 Day Multi Daily Neuronavigated Theta Burst Sessions With 6 Weeks rTMSRecruitingNCT05900271Not applicable
• In Vitro Modeling of Drug-resistant Psychiatric Disorders Using Induced Pluripotent CellsEnrolling by invitationNCT05887310
• Schema Therapy for Patients With Chronic Treatment Resistant DepressionRecruitingNCT05833087Not applicable
• Interleaved TMS-fMRI in Ultra-treatment Resistant DepressionRecruitingNCT05813093Not applicable
• Accelerated High-dose Sequential Bilateral Theta Burst Stimulation for Treatment Resistant DepressionNot yet recruitingNCT05811104Not applicable
• Translational Biomarkers in Accelerated Neuromodulation for Treatment-resistant DepressionRecruitingNCT05798143Not applicable
• NRX-101 Expanded AccessAvailableNCT05779267
• Early Identification of TRD and Construction and Clinical Validation of NTBS Precision TechnologyRecruitingNCT05777876Not applicable
• DBS for TRD With the Medtronic Percept PCRecruitingNCT05773755Not applicable
• 40 Hz Light Neurostimulation for Patients With Depression (FELIX)RecruitingNCT05680220Not applicable
• Olfactory and Brain Stimulations in Treatment-resistant DepressionRecruitingNCT05661383Not applicable
• An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant DepressionRecruitingNCT05660642Phase 2
• OSU6162 as add-on in SSRI/SNRI-resistant DepressionRecruitingNCT05641623Phase 2
• The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant DepressionRecruitingNCT05607654Not applicable
• Home-based Transcranial Direct Current Stimulation for Treatment Resistant DepressionRecruitingNCT05595356Not applicable
• E-field Guided iTBS for Treatment Resistant DepressionRecruitingNCT05583747Not applicable
• Belief Updating in Treatment Resistant DepressionRecruitingNCT05577247
• rTMS With and Without Text4Support for the Treatment of Resistant Depression.RecruitingNCT05570344Not applicable
• Auditory MMN EEG in TRD in Response to KetamineRecruitingNCT05464264
• Dorsomedial Prefrontal Neuromodulation in Treatment-resistant DepressionRecruitingNCT05422417Not applicable
• Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective ProcessingRecruitingNCT05418894Not applicable
• Psilocybin Versus Ketamine in Treatment-Resistant DepressionRecruitingNCT05383313Phase 2
• Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SIRecruitingNCT05377177Not applicable
• Neurocardiac Predictors of Treatment Response to RTMS in DepressionNot yet recruitingNCT05139862Not applicable
• TReAtment With CombinedExercise in Patients With Resistant Major DepressionRecruitingNCT05136027Not applicable
• IMPase in Treatment-resistant DepressionRecruitingNCT05117710Phase 1
• Efficacy and Biomarkers of Response of TBS in Treatment Resistant DepressionRecruitingNCT04998773Not applicable
• A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant InpatientsRecruitingNCT04996433Not applicable
• Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS TreatmentRecruitingNCT04956016Not applicable
• Comparison of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment Resistant DepressionRecruitingNCT04936126Phase 4
• Long-term Observation of Participants With Mood DisordersRecruitingNCT04877977
• The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive DisorderRecruitingNCT04805879Phase 2/3
• Brexpiprazole Treatment for Bipolar I DepressionRecruitingNCT04569448Phase 3
• University of Iowa Interventional Psychiatry Service Patient RegistryRecruitingNCT04480918
• PCS in Severe Treatment Resistant DepressionRecruitingNCT04124341Not applicable
• Biomarker-guided rTMS for Treatment Resistant DepressionRecruitingNCT04041479Phase 3
• Tractography Guided Subcallosal Cingulate Deep Brain Stimulation for Treatment Resistant DepressionRecruitingNCT03952962Not applicable
• A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant DepressionRecruitingNCT03887715Not applicable
• Antidepressant Discontinuation in Treatment Resistant DepressionRecruitingNCT03786614Not applicable
• Characterizing Synaptic Density in Treatment Resistant DepressionRecruitingNCT03537794
• A Study to Assess Effectiveness and Efficiency of VNS Therapy in Patients With Difficult to Treat Depression.RecruitingNCT03320304
• ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant DepressionRecruitingNCT03272698Phase 4
• NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain CircuitsRecruitingNCT02994433Phase 1
• Maintenance TMS in Treatment Resistant DepressionTerminatedNCT06682299Not applicableResults posted
• KET-RO Plus RO DBT for Treatment Resistant DepressionCompletedNCT06138691Phase 1Results posted
• BPL-003 Efficacy and Safety in Treatment Resistant DepressionCompletedNCT05870540Phase 2Results posted
• Study of Efficacy, Safety, Tolerability and Pharmacokinetics of MIJ821 in Participants With Treatment- Resistant Depression (TRD)CompletedNCT05454410Phase 2Results posted
• A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRDCompletedNCT05414422Phase 2Results posted
• Intensive TMS for Bipolar DepressionCompletedNCT05228457Not applicableResults posted
• Personalized Therapeutic Neuromodulation for Anhedonic DepressionCompletedNCT05144789Not applicableResults posted
• A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRDCompletedNCT05113771Phase 2Results posted
• Phase 2 Study of NV-5138 in Adults With Treatment Resistant DepressionCompletedNCT05066672Phase 2Results posted
• Targeting IL-17A for Treatment-Resistant DepressionCompletedNCT04979910Phase 2Results posted
• A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray TreatmentCompletedNCT04829318Phase 4Results posted
• Antidepressant Effects of TS-161 in Treatment-Resistant DepressionTerminatedNCT04821271Phase 2Results posted
• The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant DepressionCompletedNCT04739865Phase 2Results posted
• Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) ICompletedNCT04680910Phase 1Results posted
• Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)TerminatedNCT04663321Phase 2Results posted
• Open-Label Safety Study of AXS-05 in Subjects With TRD (EVOLVE)TerminatedNCT04634669Phase 2Results posted
• A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant DepressionCompletedNCT04599855Phase 4Results posted
• Ketamine for Older Adults PilotCompletedNCT04504175Phase 4Results posted
• Tianeptine for Treatment Resistant DepressionTerminatedNCT04249596Phase 4Results posted
• Establishing a Dose-response Relationship With Accelerated Transcranial Magnetic StimulationCompletedNCT04243798Not applicableResults posted
• Open-Label Safety Study of AXS-05 in Subjects With DepressionCompletedNCT04039022Phase 3Results posted
• Pilot Accelerated Theta Burst in Treatment-Resistant Bipolar DepressionCompletedNCT03953417Not applicableResults posted
• The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant DepressionCompletedNCT03775200Phase 2Results posted
• Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant DepressionCompletedNCT03756129Phase 2Results posted
• Accelerated Theta Burst in Treatment-Resistant Depression: A Dose Finding and Biomarker StudyCompletedNCT03680781Not applicableResults posted
• A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant DepressionCompletedNCT03434041Phase 3Results posted
• Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant DepressionTerminatedNCT03360942Not applicableResults posted
• Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing StrategiesCompletedNCT03283670Phase 2Results posted
• Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression: OL CohortCompletedNCT03240692Not applicableResults posted
• Confirmatory Efficacy and Safety Trial of Magnetic Seizure Therapy for DepressionCompletedNCT03191058Not applicableResults posted
• Salicylic Augmentation in DepressionTerminatedNCT03152409Phase 2Results posted
• A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)CompletedNCT03149991Phase 4Results posted
• ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)CompletedNCT03113968Phase 2/3Results posted
• Low Frequency TMS for Depression in EpilepsyCompletedNCT03105700Not applicableResults posted
• Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression (SAINT-TRD)CompletedNCT03068715Not applicableResults posted
• Safety, Tolerability, PK Profile, and Symptom Response of a 7-Day Dosing With 25 mg or 50 mg Daily of REL-1017 in MDDCompletedNCT03051256Phase 2Results posted
• Neuroimaging in Patients Undergoing TMS for DepressionCompletedNCT02974296Not applicableResults posted
• Optimizing Outcomes of Treatment-Resistant Depression in Older AdultsCompletedNCT02960763Phase 4Results posted
• Low Dose Intravenous Ketamine in Treatment Resistant Depression PatientsCompletedNCT02935595Phase 2Results posted
• Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in FemalesTerminatedNCT02922725Phase 4Results posted
• A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant DepressionCompletedNCT02918318Phase 2Results posted
• Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant DepressionCompletedNCT02914769Phase 1/2Results posted
• Augmentation of Treatment-Resistant Depression With An Analog of the Neuroactive Steroid AllopregnanoloneCompletedNCT02900092Not applicableResults posted
• The UTHealth Ketamine ProjectTerminatedNCT02882711Phase 2Results posted
• A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant DepressionCompletedNCT02782104Phase 3Results posted
• Repetitive Transcranial Magnetic Stimulation for Adolescent Depression: Efficacy, Predictive Biomarkers, and MechanismsCompletedNCT02611206Not applicableResults posted
• Ketamine for Treatment Resistant Late-Life DepressionCompletedNCT02556606Phase 3Results posted
• Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant DepressionCompletedNCT02522377Not applicableResults posted
• A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant DepressionCompletedNCT02497287Phase 3Results posted

← Depressive Disorder, Treatment-Resistant overview