Depressive Disorder, Treatment-Resistant: all 472 studies
Page 4 of 5. Open to participants first (151), then studies with results posted, then the rest; newest registration first within each.
- Effect of Ketamine on Neurological Activity as Measured by Electroencephalogram (EEG)TerminatedNCT05095792
- Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant DepressionCompletedNCT05045378Phase 4
- Psilocybin for Treatment-Resistant DepressionCompletedNCT05029466Phase 2
- Patient-oriented Randomized Pragmatic Feasibility Trial With rTMS in Depression and AnxietyActive, not recruitingNCT05028738Not applicable
- Sevoflurane for Treatment-Resistant DepressionStatus unknownNCT05008939Not applicable
- Nitrous Oxide for Late-Life Depression - PROTO-BRAINCompletedNCT05007028Not applicable
- Glutamate and Opioid Mechanisms of Antidepressant Response to KetamineCompletedNCT04977674Early Phase 1
- An Evaluation of AXS-05 for the Treatment of TRD in Treatment-Adherent PatientsStatus unknownNCT04971291Phase 2
- Psilocybin in Depression Resistant to Standard TreatmentsCompletedNCT04959253Phase 2
- Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot TrialCompletedNCT04957368Phase 4
- Virtual Neuro-Navigation System for Personalized Community Based TMSCompletedNCT04956081Not applicable
- Accelerated Intermittent Theta Burst Stimulation for Depressed Patients During the Covid-19 PandemicCompletedNCT04935489Not applicable
- ECT vs. EsketamineWithdrawnNCT04924257Phase 3
- TBS Over DLPFC in Elderly Refractory DepressionStatus unknownNCT04872465Not applicable
- Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic KetamineCompletedNCT04856124
- Reward Emotion Learning and Ketamine StudyStatus unknownNCT04850911Not applicable
- Add-on Therapy With Edupression.Com® on Therapy Resistant Depressive Patients Treated With Nasal Esketamine SprayStatus unknownNCT04843462Not applicable
- MAO-B Occupancy in Depressed PatientsCompletedNCT04841798Not applicable
- Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot StudyStatus unknownNCT04783103Not applicable
- Home-administered tDCS for Treatment of DepressionCompletedNCT04781127Phase 1
- The RECOVER sUb-study, Which Leverages quaNtitative and Credible Research tOols From Verily, Will providE Assessment measuRes for Depressive EpisodesTerminatedNCT04753385
- Rapid Acting Transcranial Magnetic StimulationActive, not recruitingNCT04739969Not applicable
- Cannabidiol for Treatment Resistant DepressionWithdrawnNCT04732169Phase 4
- Stellate Ganglion Block for Major Depressive Disorder.CompletedNCT04727229Phase 4
- Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in DepressionCompletedNCT04701866Not applicable
- Clinical Study of GH001 in DepressionCompletedNCT04698603Phase 1/2
- Pharmacogenetics Associated With IV KetamineCompletedNCT04695405
- Compressed Intermittent Theta Burst StimulationActive, not recruitingNCT04684706Not applicable
- Efficacy and Safety of Psilocybin in Treatment-Resistant Major DepressionCompletedNCT04670081Phase 2
- Neural Circuit Biomarkers of Transcranial Magnetic Stimulation StudyActive, not recruitingNCT04663841
- Mechanistic Evaluation of Response in TRD (MERIT)CompletedNCT04608396Phase 2
- The Efficacy and Prediction of Deep Brain Stimulation for Treatment-resistant DepressionActive, not recruitingNCT04530942Not applicable
- Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)CompletedNCT04519957
- Near-Infrared Laser Stimulation for Various Neurological ConditionsStatus unknownNCT04489082Not applicable
- An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment AlternativesCompletedNCT04476446Phase 3
- Dopaminergic Dysfunction in Late-Life DepressionCompletedNCT04469959Phase 2
- Pharmacogenetic Implementation Trial in Veterans With Treatment Refractory DepressionCompletedNCT04469322Not applicable
- CET- REM (Correlating ECT Response to EEG Markers)Active, not recruitingNCT04451135Not applicable
- An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)Active, not recruitingNCT04433858Phase 2
- The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression.Status unknownNCT04433845Phase 2
- Healthy Lifestyle Promotion as Adjunctive Teletherapy for Treatment-resistant Major DepressionStatus unknownNCT04428099Not applicable
- Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant DepressionCompletedNCT04239963
- rTMS With and Without iCBT For the Treatment of Resistant Depression (TRD)CompletedNCT04239651Not applicable
- A Naturalistic Study of Ketamine for Treatment Resistant Mood DisordersCompletedNCT04226963
- Three Dosing Regimens of Dextromethorphan (DXM) Reportedly Used in Major Depressive DisorderCompletedNCT04226352Phase 1
- Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal KetamineCompletedNCT04216888Phase 2/3
- Focused Ultrasound and Exosomes to Treat Depression, Anxiety, and DementiasSuspendedNCT04202770Not applicable
- Brain Reactivity to Nitrous Oxyde in Depression : an MRI and Ultrasound Study (PROTOBRAIN Pilote)CompletedNCT04199143Not applicable
- SAINT for Treatment of Preoperative Depression to Reduce Opioid Use Following ArthroplastyWithdrawnNCT04195308Not applicable
- Computational Psychiatric Approach to DepressionCompletedNCT04189939
- Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant AgentStatus unknownNCT04171193Phase 2
- Psychotherapeutic Augmentation of Brain Stimulation EffectsCompletedNCT04159285Not applicable
- NESBID: Neuro-Stimulation of the Brain in DepressionWithdrawnNCT04159012Not applicable
- Clinical Study on the Safety and Effectiveness of Vagus Nerve Stimulation in the Treatment of Refractory DepressionStatus unknownNCT04153812Phase 1/2
- DBS for TRD With the Medtronic Summit RC+SActive, not recruitingNCT04106466Not applicable
- Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on SuicidalityCompletedNCT04101474Not applicable
- Enhanced Spatial Targeting in ECT Utilizing FEASTSuspendedNCT04099342Not applicable
- Neurofeedback In Treatment Resistant DepressionTerminatedNCT04078438Not applicable
- Brain-derived Neurotrophic Factor and the Antidepressant Efficacy of Brain StimulationStatus unknownNCT04076124Not applicable
- Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed PatientsCompletedNCT04037592Not applicable
- Repeated Ketamine Infusions for Comorbid PTSD and MDD in VeteransCompletedNCT04032301Phase 1
- Neurobiological Analyses Within the FORESEE III StudyStatus unknownNCT04021823
- Deep Brain Stimulation for Treatment Resistant DepressionStatus unknownNCT04009928Phase 1/2
- rTMS Intervention on Motivational Anhedonia of Treatment Resistant Depression and Brian Network MechanismStatus unknownNCT03991572Not applicable
- Linear Asymmetric rTMS in Adolescent Treatment-Resistant Depression: Tolerability of Treatment Durations Ranging From Ten Days to One DayStatus unknownNCT03986658Not applicable
- Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in DepressionCompletedNCT03977038
- Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant DepressionCompletedNCT03965858Phase 2
- Minocycline as Adjunctive Treatment for Treatment Resistant DepressionCompletedNCT03947827Phase 3
- Nitrous Oxide for Major Depressive DisorderCompletedNCT03932825Phase 2
- Neural and Antidepressant Effects of Propofol (Phase 2)WithdrawnNCT03923361Phase 2/3
- Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression.CompletedNCT03887624Early Phase 1
- A Study of Esketamine Nasal Spray Plus a New Standard-of-care Oral Antidepressant or Placebo Nasal Spray Plus a New Standard-of-care Oral Antidepressant in Adult and Elderly Participants With Treatment-resistant DepressionWithdrawnNCT03852160Phase 3
- Improving Brain Stimulation Through ImagingCompletedNCT03851380
- Glabellar Botulinum Toxin Injections for the Treatment of Geriatric DepressionWithdrawnNCT03833063Phase 1
- Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)Approved for marketingNCT03829579
- Evaluation of Schemes of Administration of Intravenous Ketamine in DepressionStatus unknownNCT03742557Phase 3
- Efficacy of Convulsive Therapies During ContinuationCompletedNCT03711019Not applicable
- Cost-utility Analysis of Maintenance rTMS for Treatment-resistant DepressionStatus unknownNCT03701724Not applicable
- Neural and Antidepressant Effects of PropofolCompletedNCT03684447Phase 2/3
- Efficacy and Safety of DBS in Patients With Treatment-Resistant DepressionStatus unknownNCT03667872Not applicable
- Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and SuicideStatus unknownNCT03666390Not applicable
- Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major DepressionCompletedNCT03653858Not applicable
- Investigating Predictors of Treatment Response in Treatment-Resistant Depression (TRD) With Interleaved TMS/fMRICompletedNCT03642522Not applicable
- Biomarkers of Theta Burst Stimulation in Major Depressive DisorderStatus unknownNCT03626181Not applicable
- Safety, Tolerability, PK and Efficacy of Single Doses of NV-5138 in Healthy Volunteers and Subjects With Treatment-Resistant DepressionCompletedNCT03606395Phase 1
- Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:Active, not recruitingNCT03573349Early Phase 1
- SSM vs HEP in Late-Life DepressionTerminatedNCT03564041Not applicable
- PF-04995274 and Emotional Processing in Treatment Resistant DepressionCompletedNCT03515733Phase 1
- Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial.CompletedNCT03435744Phase 3
- Neurofeedback for Treatment Resistant DepressionCompletedNCT03428828Not applicable
- Treatment-Resistant Depression Cohort in EuropeCompletedNCT03373253
- Psychosocial Characteristics and Non-pharmacological Intervention of Patients With Treatment-resistant DepressionCompletedNCT03329391Not applicable
- Fermented Milk Product With Probiotic and Its Impact on Mood of Patients With Treatment Resistant DepressionCompletedNCT03317678Not applicable
- Efficacy and Safety of TAK-653 in Treatment-Resistant DepressionWithdrawnNCT03312894Phase 2
- Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving KetamineWithdrawnNCT03290963Phase 2
- Stepped Care AiTBS 2 Depression Study (Ghent)CompletedNCT03288675Not applicable
- TBS in Major DepressionStatus unknownNCT03257397Not applicable
- Treatment Resistant Depression in America LatinaCompletedNCT03207282
- Investigational TMS Treatment for DepressionWithdrawnNCT03175887Not applicable
- Neurocognitive Features of Patients With Treatment-Resistant DepressionCompletedNCT03134066