Cholestasis clinical trials
The registry lists 150 studies for Cholestasis across more than 10 countries. 18 are recruiting or about to start. 68 of them are mainly about Cholestasis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-21. Counting its 5 narrower conditions too, such as Liver Cirrhosis, Biliary: 414 studies, 86 open.
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Breast cancer · Recruiting: 2 came in, 3 changed
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A study of drug A after surgery for early breast cancer
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Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
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Who runs them
Mirum Pharmaceuticals, Inc. (9) · GlaxoSmithKline (6) · Arbor Research Collaborative for Health (4) · Albireo (3) · University of Aarhus (3) · Children's Hospital Medical Center, Cincinnati (3) · The University of Texas Health Science Center at San Antonio (2) · Baylor College of Medicine (2)
What is being tested here
Drugs under test in Cholestasis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Nov 2026Vitamin D2 vs Vitamin D2 Plus Calcitriol in Cholestatic Children With Vitamin D Deficiency · Chulalongkorn University
- Dec 2026Congenital Heart Diseases and Developmental Assessment in Cholestatic Infants Under Two Years · Assiut University
- Dec 2026Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease · Children's Hospital Medical Center, Cincinnati
- Mar 2027The Use of Near-Infrared Fluorescence Cholangiography With Indocyanine Green (ICG) in the Work Up of Neonatal Cholestasis · University of Alabama at Birmingham
Who these studies take
Of the 9 Cholestasis studies recruiting now, 1 (11%) set no upper age limit and 8 (89%) stop at 75 or younger. 6 (67%) take children under 18. 1 (11%) are for women only and 0 (0%) for men only; 2 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (44%) | 4 (44%) |
| 18 | 7 (78%) | 6 (67%) |
| 30 | 4 (44%) | 3 (33%) |
| 40 | 4 (44%) | 3 (33%) |
| 50 | 4 (44%) | 3 (33%) |
| 65 | 3 (33%) | 3 (33%) |
| 75 | 3 (33%) | 3 (33%) |
| 85 | 1 (11%) | 1 (11%) |
Across all 150 studies, recruiting or not: 57% stop at 75 or younger and 53% at 65; 55% take children; 5% are for women only and 1% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Cholestasis studies take
Of 12 phase 3 interventional studies under Cholestasis, half reached primary completion within 38 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 38 mo26–64 · 12 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 150. Browse all 150 → or search them.
- Pediatric Evaluation and Registry for Liver Cholestasis in CanadaRecruitingNCT074117161 country
- Nemolizumab for the Treatment of Moderate to Severe Chronic Hepatic PruritusNot yet recruitingNCT07843420Phase 21 country
- Vitamin D2 vs Vitamin D2 Plus Calcitriol in Cholestatic Children With Vitamin D DeficiencyRecruitingNCT07670611Phase 41 country
- Long-Term Low-Intervention SafEty and Clinical Outcomes Clinical Study of LivmArli® in Patients With Alagille Syndrome or Progressive Familial Intrahepatic Cholestasis in the European Union (LEAP-EU)RecruitingNCT07290257Phase 48 countries
- Biliary Atresia Study in Infants and ChildrenRecruitingNCT003455532 countries
- Tolerability of Enteral NAC in InfantsNot yet recruitingNCT06260566Phase 1
- The Use of Near-Infrared Fluorescence Cholangiography With Indocyanine Green (ICG) in the Work Up of Neonatal CholestasisRecruitingNCT07250854Early Phase 11 country
- Maralixibat for Intrahepatic Cholestasis of PregnancyNot yet recruitingNCT07389031Phase 21 country
- Congenital Heart Diseases and Developmental Assessment in Cholestatic Infants Under Two YearsNot yet recruitingNCT07247604
- A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSCRecruitingNCT06699121Phase 21 country
- Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental InflammationRecruitingNCT051973871 country
- PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Cholestatic Disorders in Patients with Genetic Liver Disorders and Healthy IndividualsEnrolling by invitationNCT066106951 country
- Prediction Model for Early Biliary Stasis After Bariatric SurgeryNot yet recruitingNCT06385860
- Investigation of the Pruritogens of Liver-related DiseasesNot yet recruitingNCT063649691 country
- Parenteral Nutrition Cycling for Prevention of Cholestatic Syndrome in NewbornRecruitingNCT06366880Not applicable1 country
- Flare Type Self-expandable Metal Stents (SEMS) vs Plastic Stent for the Treatment of Difficult Common Bile Duct StoneNot yet recruitingNCT06170632Not applicable1 country
- Impact of the Stool Color Scale on the Detection of Neonatal CholestasisNot yet recruitingNCT060482111 country
- FGF19 in Obstructive Cholestasis: "Unveil the Signal"RecruitingNCT057183491 country
- Long Term Safety & Efficacy Study Evaluating The Effect of A4250 in Children With PFICCompletedNCT03659916Phase 315 countries
- A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)Active, not recruitingNCT04663308Phase 214 countries
- Expanded Access of Omegaven IV Fat Emulsion to Infants and Children With PNALDApproved for marketingNCT029293031 country
- Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary CholangitisCompletedNCT04604652Phase 21 country
- A Study to Assess the Genetic Variations in Bile Flow Disorders: Linking Progressive Familial Intrahepatic Cholestasis (PFIC)-Related Genes to Symptoms in Adults With Recurrent Cholestasis in SpainCompletedNCT071917041 country
- Odevixibat for the Treatment of Progressive Familial Intrahepatic CholestasisNo longer availableNCT044835311 country
- Global Linerixibat Itch Study of Efficacy and Safety in Primary Biliary Cholangitis (PBC) (GLISTEN)CompletedNCT04950127Phase 32 countries
- An Extension Study of Maralixibat in Patients With Progressive Familial Intrahepatic Cholestasis (PFIC)CompletedNCT04185363Phase 316 countries
- Linerixibat Long-term Safety, and Tolerability StudyActive, not recruitingNCT04167358Phase 317 countries
- Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)SuspendedNCT005712722 countries
- Longitudinal Study of Mitochondrial HepatopathiesSuspendedNCT011485502 countries
- Mallampati Score for Prediction and Prognosis of Postoperative Mortality and Morbidity and Safety Profiles of Patients Undergoing Laparoscopic Cholecystectomy in Qassim RegionCompletedNCT060057011 country
- Use of Omegaven Fish Oil Emulsion for Parenteral Nutrition Associated Liver Disease in Infants and ChildrenCompletedNCT01194063Phase 31 country
- Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver DiseaseActive, not recruitingNCT055824471 country
- This Study Will Investigate the Efficacy and Safety of A4250 in Children With PFIC Types 1 or 2CompletedNCT03566238Phase 315 countries
- SMOF Lipid for Children With Parenteral Nutrition Induced Liver InjuryApproved for marketingNCT024125661 country
- Evaluate the Safety, Tolerability, and PK of EP547 in Healthy Subjects and Subjects With Cholestatic or Uremic PruritusCompletedNCT04510090Phase 12 countries
- Comparison of Smoflipid to Soy-based Lipid Reduction for Cholestasis Prevention in Surgical NeonatesCompletedNCT03387579Phase 31 country
- A Study of Endobiliary Radiofrequency Ablation in Malignant Biliary ObstructionsCompletedNCT058266391 country
- Needle-Knife Fistulotomy Vs. Standard Cannulation TrialCompletedNCT06694038Phase 1/21 country
- PET/CT Scans Using the Tracer 11C-Csar, a Bile Acid Analog, to Depict and Visualize Changes in the Hepatobiliary System in Patients With Primary Biliary Cholangitis Before and After Treatment.Active, not recruitingNCT066049231 country
- Cholestasis Reversal: Efficacy of IV Fish OilCompletedNCT00910104Phase 2/31 country
- FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)CompletedNCT029227512 countries
- A Placebo-controlled Study of Volixibat in Subjects With Elevated Serum Bile Acids Associated With Intrahepatic Cholestasis of Pregnancy (OHANA)TerminatedNCT04718961Phase 23 countries
- Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in InfantsApproved for marketingNCT025340771 country
- A4250, an IBAT Inhibitor in Pediatric CholestasisCompletedNCT02630875Phase 25 countries
- Compassionate Use of Omegaven® for the Treatment of Intestinal Failure Associated Liver Disease in ChildrenApproved for marketingNCT023287681 country
- A Study to Evaluate the Efficacy and Safety of Maralixibat in Subjects With Progressive Familial Intrahepatic Cholestasis (MARCH-PFIC)CompletedNCT03905330Phase 317 countries
- SpyGlass™ Discover PercutaneousCompletedNCT045809407 countries
- Open Label Study to Evaluate Efficacy and Long Term Safety of LUM001 (Maralixibat) in the Treatment of Cholestatic Liver Disease in Patients With Progressive Familial Intrahepatic CholestasisCompletedNCT02057718Phase 24 countries
- Evaluation of Omegaven™ Parenteral Nutrition in Patients With Total Parenteral Nutrition (TPN)-Induced CholestasisCompletedNCT00826020Phase 21 country
- Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic AcidCompletedNCT00007020Phase 31 country