Brain Edema clinical trials
The registry lists 102 studies for Brain Edema across more than 10 countries. 25 are recruiting or about to start. 32 of them are mainly about Brain Edema (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-14.
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Who runs them
Children's Hospital Medical Center, Cincinnati (8) · Celtic Pharma Development Services (4) · Peter Siesjö (4) · Nanfang Hospital, Southern Medical University (3) · Xuanwu Hospital, Beijing (3) · University of Zurich (2) · Beijing Tiantan Hospital (2) · Second Affiliated Hospital, School of Medicine, Zhejiang University (2)
What is being tested here
Drugs under test in Brain Edema studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8, phase 3 first
- Jun 2027The Efficacy and Safety of HRS8179 in Severe Cerebral Edema Following Large Hemispheric Infarction · Phase 3 · Beijing Suncadia Pharmaceuticals Co., Ltd
- Nov 2026Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH) · Johns Hopkins University
- Dec 2026Antisecretory Factor In Severe Traumatic Brain Injury · Peter Siesjö
- Mar 2027Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study) · Zhejiang Provincial People's Hospital
- Apr 2027Butylphthalide for Brain Edema After Endovascular Treatment · Nanfang Hospital, Southern Medical University
- Jul 2027Modulating Inflammation in Neuro-Trauma · The University of Texas Health Science Center at San Antonio
- Sep 2027ONSD Trajectory in Rebound ICH · Benha University
- Oct 2027Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial Pressure · Assiut University
Who these studies take
Of the 10 Brain Edema studies recruiting now, 2 (20%) set no upper age limit and 2 (20%) stop at 75 or younger. 1 (10%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (10%) | 1 (10%) |
| 18 | 9 (90%) | 9 (90%) |
| 30 | 10 (100%) | 10 (100%) |
| 40 | 10 (100%) | 10 (100%) |
| 50 | 10 (100%) | 10 (100%) |
| 65 | 10 (100%) | 10 (100%) |
| 75 | 9 (90%) | 9 (90%) |
| 85 | 2 (20%) | 2 (20%) |
Across all 102 studies, recruiting or not: 38% stop at 75 or younger and 25% at 65; 23% take children; 0% are for women only and 1% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Brain Edema studies take
Of 15 observational studies under Brain Edema, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 23 mo6–32 · 15 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 12, 2026.
Newly registered1
- Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)Oct 14, 2026NCT07872774
Studies
Recruiting first, then most recently updated. Showing 50 of 102. Browse all 102 → or search them.
- Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)Not yet recruitingNCT078727741 country
- Modulating Inflammation in Neuro-TraumaNot yet recruitingNCT07510074Not applicable1 country
- Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain MetastasesNot yet recruitingNCT07841106Phase 2
- Transcranial Doppler Evaluation After Endovascular Thrombectomy for Acute Ischemic Stroke (PRECISE-TCD)Not yet recruitingNCT070133961 country
- TENS of Auricular Vagal Nerve for Radiation NecrosisNot yet recruitingNCT07680127Not applicable1 country
- Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial PressureNot yet recruitingNCT07799714
- International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of HyponatremiaEnrolling by invitationNCT075760361 country
- A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic StrokeNot yet recruitingNCT07386262Not applicable1 country
- ONSD Trajectory in Rebound ICHNot yet recruitingNCT077227021 country
- Butylphthalide for Brain Edema After Endovascular TreatmentNot yet recruitingNCT07528456Phase 41 country
- Early Prophylactic Decompressive Hemicraniectomy Following Endovascular Therapy in Large Hemispheric Infarct TrialRecruitingNCT07118345Not applicable1 country
- Antisecretory Factor In Severe Traumatic Brain InjuryRecruitingNCT04117672Phase 21 country
- Effect of Volatile- Based Versus Total Intravenous Anesthesia on Brain Homeostasis and Neurocognitive OutcomeRecruitingNCT06779890Phase 41 country
- High-volume Versus Standard Volume Plasma Exchange in Patients With Acute Liver Failure With Cerebral EdemaNot yet recruitingNCT06515145Not applicable1 country
- The Efficacy and Safety of HRS8179 in Severe Cerebral Edema Following Large Hemispheric InfarctionRecruitingNCT06732648Phase 2/31 country
- Setting Families on a Positive Path to Recovery After Pediatric TBI: Road-to-RecoveryRecruitingNCT05622461Not applicable1 country
- Impact of Salovum® and SPC® Flakes on Brain Tumor Induced EdemaRecruitingNCT06710249Phase 21 country
- Early Identification of Malignant Brain Edema in laRge Artery oCclusive Stroke After Endovascular Therapy (EMBRACE Study)RecruitingNCT064518871 country
- Haemodynamical Optimization During Brain SurgeryRecruitingNCT04114799Not applicable1 country
- Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion InjuryRecruitingNCT055852551 country
- Rapid Local Ischemic Postconditioning in Acute Ischemic StrokeNot yet recruitingNCT06307743Not applicable
- Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain InjuryNot yet recruitingNCT06096415Phase 2
- Non-invasive Monitoring and Serum Marker Study in Children With Cerebral EdemaNot yet recruitingNCT06017635
- Inflammation and Coagulation Factors for Predicting Cerebral Edema After SAHRecruitingNCT060090161 country
- Reducing Edema After intraCerebral HemorrhageNot yet recruitingNCT05263167Phase 4
- Implementation of Neuro Lung Protective VentilationActive, not recruitingNCT03243539Not applicable1 country
- Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)Active, not recruitingNCT05020535Phase 21 country
- Wet and Dry Biomarkers to Predict Secondary Injury in Stroke: From Bench to Bedside - The NIMBLE StudyCompletedNCT074226361 country
- Trial of Dexamethasone for Traumatic Brain Injured Patients With Brain Contusions and Pericontusional EdemaTerminatedNCT04303065Phase 31 country
- Local Ischemic Postconditioning in Acute Ischemic StrokeCompletedNCT06526429Not applicable1 country
- AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head InterpretationCompletedNCT060185451 country
- Automatic PredICtion of Edema After StrokeActive, not recruitingNCT040576903 countries
- Bleeding Intracerebral Hemorrhage With Early Invasive Intracranial Pressure Monitoring TrialCompletedNCT05593380Not applicable1 country
- "The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients"CompletedNCT06656442Phase 31 country
- Intravenous BCAA for HE in ACLF (BCAA-HE-ACLF)CompletedNCT05700695Phase 11 country
- Fingolimod as a Treatment of Cerebral Edema After Intracerebral HemorrhageCompletedNCT04088630Early Phase 11 country
- A Trial of HRS8179 on Brain Swelling After Large Hemispheric InfarctionCompletedNCT05690711Phase 21 country
- Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric InfarctionTerminatedNCT02864953Phase 324 countries
- Swiss Prospective Autologous Bone Flap Resorption StudyTerminatedNCT023209551 country
- Diabetic Ketoacidosis Diagnosis and ManagementCompletedNCT063277371 country
- Head Computed Tomography for Predicting Neurological Outcome After Cardiac ArrestCompletedNCT039130651 country
- The Effect of Lumbar CSF Drainage on the Neurologic Outcome Improvement in OHCA Underwent TTMCompletedNCT043289741 country
- The Tolerability, Safety, and PK Characteristics of SIM1910-09 in Healthy Chinese VolunteersCompletedNCT05200728Phase 11 country
- Early Induced Hypernatremia for the Prevention and Management of Brain EdemaWithdrawnNCT02798601Not applicable
- Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral EmbolismCompletedNCT03284463Phase 2/31 country
- Study on Data Acquisition and Image Characteristics of Brain Multifrequency EIT in Healthy People and Patients With Brain DiseasesCompletedNCT057963491 country
- Effects of Intraoperative GDFT on the Postoperative Brain EdemaCompletedNCT03323580Not applicable1 country
- Acute Ischaemic STROKE: From LAboratory to the Patient's BEDStatus unknownNCT05725694
- SMCV Assessment on Brain Swelling in Patients With SAH From Ruptured Artery AneurysmStatus unknownNCT057147351 country
- SMCV Assessment on Brain Swelling in Patients With SAHStatus unknownNCT056966391 country