Ankyloglossia clinical trials
The registry lists 32 studies for Ankyloglossia across more than 10 countries. 8 are recruiting or about to start. 28 of them are mainly about Ankyloglossia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
The Oregon Clinic (4) · Parc de Salut Mar (3) · Europa Life Sciences Limited (2) · University of Oslo (1) · Istanbul Health and Technology University (1) · Isaac Elijah (1) · Hanoi Medical University (1) · The Children's Hospital of Zhejiang University School of Medicine (1)
What is being tested here
Drugs under test in Ankyloglossia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Human colostrum | 0 | 0 | 1 |
| Ibuprofen | 0 | 0 | 1 |
| Lavender oil | 0 | 0 | 1 |
| Benzocaine | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026SNIP follow-on Case Series Using v3 Device · Europa Life Sciences Limited
- Mar 2027The Impact of Post-Frenotomy Massages on Ankyloglossia Recurrence and Feeding Outcomes · Isaac Elijah
Who these studies take
Of the 4 Ankyloglossia studies recruiting now, 1 (25%) set no upper age limit and 3 (75%) stop at 75 or younger. 4 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (25%) | 1 (25%) |
| 18 | 1 (25%) | 1 (25%) |
| 30 | 1 (25%) | 1 (25%) |
| 40 | 1 (25%) | 1 (25%) |
| 50 | 1 (25%) | 1 (25%) |
| 65 | 1 (25%) | 1 (25%) |
| 75 | 1 (25%) | 1 (25%) |
| 85 | 1 (25%) | 1 (25%) |
Across all 32 studies, recruiting or not: 94% stop at 75 or younger and 94% at 65; 100% take children; 0% are for women only and 0% for men only; 47% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Newly registered1
- Impact of Lingual Frenulum Variations on Orofacial Growth in ChildrenNov 9, 2026NCT07924163
Studies
Recruiting first, then most recently updated. Showing 32 of 32. search them.
- Effectivity of P1821, a Novel Tongue Strengthening and Endurance Enhancing Speech Flow ExerciseRecruitingNCT07719582Not applicable1 country
- Long-term Follow-up of Infant Frenotomy/Frenectomy Through Early ChildhoodEnrolling by invitationNCT071109481 country
- SNIP follow-on Case Series Using v3 DeviceNot yet recruitingNCT07796165Not applicable1 country
- Ankyloglossia and BreastfeedingNot yet recruitingNCT077575031 country
- The Impact of Post-Frenotomy Massages on Ankyloglossia Recurrence and Feeding OutcomesRecruitingNCT07738185Not applicable1 country
- Healing Efficacy of Diode Laser in Lingual FrenectomyRecruitingNCT07557875Not applicable1 country
- Post-Procedural Manual Manipulation for Infant AnkyloglossiaRecruitingNCT06830148Not applicable1 country
- Frenuloplasty for Speech and Myofunctional OutcomesNot yet recruitingNCT06089629Not applicable
- Impact of Lingual Frenulum Variations on Orofacial Growth in ChildrenCompletedNCT079241631 country
- Tongue Mobility in Patients With Ankyloglossia Following FrenectomyCompletedNCT068565641 country
- Case Series of Infants With Anterior Ankyloglossia Being Treated by the Sublingual Neonatal Incision Platform DeviceActive, not recruitingNCT07655895Not applicable1 country
- Ankyloglossia and Its Effects on Breastfeeding, Feeding and Speech Disorders. A Prospective Study From Birth to 4 Years of Age.Active, not recruitingNCT075127651 country
- Lingual Frenulum in Newborn Infants (LINNE)Active, not recruitingNCT05560750Not applicable1 country
- Breastfeeding Duration and Tongue-tie in Neonates.CompletedNCT05946590Not applicable1 country
- Analgesia in Lingual Frenulotomy in the NewbornCompletedNCT04440462Not applicable1 country
- Use of Inhaled Colostrum to Control Pain in Neonatal Frenotomy and Comparison to Inhaled Lavender Essential OilCompletedNCT06869902Not applicable1 country
- Evaluation of the Effects of Tongue-Tie and Upper Lip-TieCompletedNCT068264821 country
- Physiotherapy in the Treatment of Breastfeeding DifficultiesCompletedNCT05843279Not applicable1 country
- Efficacy of Neonatal Release of AnkyloglossiaCompletedNCT00967915Not applicable1 country
- Prevalence of Tongue Anomalies in Egyptian ChildrenCompletedNCT057796181 country
- The Effect of Pre-emptive Analgesia on the Postoperative Pain in Children Undergoing Pediatric Stomatology Day SurgeriesCompletedNCT05878262Not applicable1 country
- Dedicated Lactation Support in Infants With Tongue - Tie; a Randomised Control TrialWithdrawnNCT05135481Not applicable1 country
- Analgesic Effect of Inhaled Lavender Essential Oil for Clipping of Tongue-tiesCompletedNCT04877392Not applicable1 country
- The Impact of Lingual Frenotomy on Bottle Feeding MechanicsCompletedNCT03793413Not applicable1 country
- Comparison Among Propofol, Alfentanil and Rocuronium as Adjunct to Sevoflurane Anesthesia for Endotracheal Intubation in Children With FrenectomyCompletedNCT01550354Not applicable1 country
- Incidence of Short Sublingual Frenulum in Newborns at the Hospital Nostra Senyora de Meritxell.CompletedNCT047039461 country
- The Use of Lavender vs Vanilla Essential Oil as Complementary Analgesia for Frenotomy in Healthy NewbornsStatus unknownNCT04867824Not applicable
- The Scope of Tongue-tie in Norway: Its Prevalence and Consequences for Child HealthStatus unknownNCT04056936
- Prospective Evaluation of Lingual Frenotomy in Newborns With Simultaneous Lip Tie for the Relief of Breastfeeding Pain.CompletedNCT02141243Not applicable1 country
- Anterior Lingual Frenectomy is Inadequate in Improving Breastfeeding Outcomes: a Prospective Cohort StudyCompletedNCT02936518Not applicable
- Breastfeeding Improvement Following Tongue-tie and Lip-tie ReleaseCompletedNCT02642133Not applicable
- Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the NewbornTerminatedNCT01274247Phase 1/21 country