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TerminatedNCT01274247Updated Aug 2, 2012

Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn

A Phase 1/2 interventional study of Topical Benzocaine in Neonatal Tongue-tie, Maternal Nipple Pain Upon Breastfeeding and Neonatal Latch Difficulties, sponsored by Tel-Aviv Sourasky Medical Center. Terminated at 1 site in Israel. Open to participants aged 12 Hours to 7 Days, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-08-02.

Sponsored by Tel-Aviv Sourasky Medical Center · Phase 1/2, Interventional, and Treatment

Why this study was terminated
The study ethics committee recommended concluding the study for longer crying time with benzocaine and very short crying time in all participants.
Phase
Phase 1/2
Study type
Interventional
Enrollment
21
Allocation
Randomized
Ages
12 Hours to 7 Days
Sex
All
01

Study summary

Frenotomy of tongue-tie is commonly performed to resolve breastfeeding difficulties, eg maternal nipple pain and infant's latching difficulties. The procedure carries minor discomfort for the infants. It is not known whether the use of topical benzocaine, a very bitter tasting material' applied to the tongue-tie would decrease the length of cry. We will measure the duration of crying in infants treated with topical benzocaine to the duration in those not treated with the mediation.

02

Conditions studied

  • Neonatal Tongue-tie
  • Maternal Nipple Pain Upon Breastfeeding
  • Neonatal Latch Difficulties

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Keywords

  • Tongue-tie
  • Ankyloglossia
03

Who can participate

Ages eligible
12 Hours to 7 Days
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Full term Newborn infant
  • Tongue-tie upon physical examination
  • Maternal complains of nipple pain or difficult latch

Exclusion criteria

Exclusion Criteria:

  • Abnormal oral or nasopharyngeal anatomy
  • Any known congenital malformations
  • Prematurity
04

Study design

Phase
Phase 1 / Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
21 participants (actual)

Study arms

  • Active comparator
    Topical Benzocaine

    For infants treated with topical benzocaine prior to the procedure

    Drug: Topical Benzocaine

  • No intervention
    no benzocaine

    No benzocaine applied

Interventions

  • DrugTopical Benzocaine

    Topical administration of a drop of benzocaine to the lingual frenulum

05

What researchers measure

Primary outcomes

  1. Duration of cry after lingual frenotomy

    Time frame: 10 minutes

06

Study locations

1 site
  • Department of Neonatology, Tel AViv Medical Center
    Tel AViv, 64239, Israel
07

Registry details

Key details

Study ID
NCT01274247
Lead sponsor
Tel-Aviv Sourasky Medical Center
Responsible party
Sponsor
First posted
Jan 11, 2011
Start date
Feb 2011
Primary completion
Jun 2012
Completion
Jun 2012
Last update
Aug 2, 2012

Study contacts

Shaul Dollberg, MD
principal investigator · Tel Aviv Medical Center

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is terminated, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.

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