An interventional study of L-PRF with antimicrobial photodynamic therapy and antimicrobial photodynamic therapy without L-PRF in L-PRF, Photodynamic Therapy and Aggressive Periodontitis, sponsored by Kafrelsheikh University. Recruiting at 1 site in Egypt. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-04-11.
Sponsored by Kafrelsheikh University · Not applicable, Interventional, and Treatment
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria. Leukocyte and platelet-rich fibrin (L-PRF) has been used extensively in the treatment of intrabony defects and achieved excellent results. It acts as an immune regulation node with inflammation control abilities, including a slow continuous release of growth factors which stimulates periodontal regeneration. The aim of this study is to evaluate the adjunctive effects of aPDT with and without L-PRF in aggressive periodontitis patients.
63 studies on the registry are indexed under Aggressive Periodontitis; 5 are open to participants now.
This study's planned enrollment of 20 is below the median of 34 across 41 interventional studies indexed under Aggressive Periodontitis.
Browse Aggressive Periodontitis studies →Kafrelsheikh University is the lead sponsor of 294 studies on the registry; 114 are open to participants now.
Of its 10 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Application of L-PRF with antimicrobial photodynamic therapy in the defect
Procedure: L-PRF with antimicrobial photodynamic therapy
Application antimicrobial photodynamic therapy in the defect
Procedure: antimicrobial photodynamic therapy without L-PRF
Application of L-PRF with antimicrobial photodynamic therapy in the defect
application of antimicrobial photodynamic therapy without L-PRF in the defect
Clinical evaluation and measurements of the defect in millimeters
Changes in clinical measurements in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF
Time frame: 9 months
Radiographic evaluation and measurements of the defect in millimeters
Changes in bone formation in millimeters after application of antimicrobial photodynamic therapy with and without L-PRF
Time frame: 9 months
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