Addison Disease clinical trials
The registry lists 36 studies for Addison Disease across more than 10 countries. 9 are recruiting or about to start. 23 of them are mainly about Addison Disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Haukeland University Hospital (5) · Hopital La Rabta (2) · University of Roma La Sapienza (2) · Wuerzburg University Hospital (2) · University of Wuerzburg (2) · University of California, San Francisco (2) · Appalachian State University (1) · The Leeds Teaching Hospitals NHS Trust (1)
What is being tested here
Drugs under test in Addison Disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Hydrocortisone | 0 | 1 | 8 |
| Hydrocortisone hemisuccinate | 0 | 1 | 3 |
| Betamethasone | 0 | 0 | 1 |
| Prednisone | 0 | 0 | 1 |
| Glycyrrhiza glabra extract | 0 | 0 | 1 |
| Grapefruit juice | 0 | 0 | 1 |
| Etomidate | 0 | 0 | 1 |
| Dehydroepiandrosterone | 0 | 1 | 1 |
Drug classes tested here Corticosteroids 10
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Growing up With the Young Endocrine Support System (YESS!) · dr. Laura C. G. de Graaff-Herder
- Dec 2026SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International) · University of California, San Francisco
- Dec 2026Telehealth Music Therapy for Adults With Endocrine Disorder and Depression · Appalachian State University
Who these studies take
Of the 7 Addison Disease studies recruiting now, 5 (71%) set no upper age limit and 1 (14%) stop at 75 or younger. 3 (43%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (43%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (43%) | 3 (43%) |
| 18 | 7 (100%) | 7 (100%) |
| 30 | 7 (100%) | 7 (100%) |
| 40 | 7 (100%) | 7 (100%) |
| 50 | 7 (100%) | 7 (100%) |
| 65 | 7 (100%) | 7 (100%) |
| 75 | 6 (86%) | 6 (86%) |
| 85 | 5 (71%) | 5 (71%) |
Across all 36 studies, recruiting or not: 44% stop at 75 or younger and 25% at 65; 19% take children; 6% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid DisordersOct 20, 2026NCT04374721
Studies
Recruiting first, then most recently updated. Showing 36 of 36. search them.
- Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena)RecruitingNCT079201981 country
- Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at SanfordRecruitingNCT017931681 country
- Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid DisordersRecruitingNCT04374721Not applicable1 country
- Natural History of Sphingosine Phosphate Lyase Insufficiency Syndrome (SPLIS)RecruitingNCT066699491 country
- Telehealth Music Therapy for Adults With Endocrine Disorder and DepressionRecruitingNCT07413874Not applicable1 country
- Risks of Ramadan Fasting in Patients With Primary Adrenal Insufficiency Treated With Prednisolone.Not yet recruitingNCT07367425Not applicable1 country
- SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)RecruitingNCT048851791 country
- Growing up With the Young Endocrine Support System (YESS!)Not yet recruitingNCT04252001Not applicable4 countries
- Does Relative Hypoglycaemia &/or Sleep Disturbance Contribute to the Lethargy Observed in Addison's DiseaseRecruitingNCT055150551 country
- Chronocort Versus Plenadren Replacement Therapy in Adults With Adrenal InsufficiencyCompletedNCT05222152Phase 22 countries
- Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's DiseaseActive, not recruitingNCT03793114Not applicable3 countries
- A Study of Markers of Glucocorticoid Effects in Patients With Addisons Disease (DOSCORT)CompletedNCT03210545Phase 41 country
- Risks of Intermittent Fasting in Patients With Primary Adrenal InsufficiencyCompletedNCT06299020Not applicable1 country
- Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal HyperplasiaCompletedNCT02096510Phase 1/21 country
- Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 DiabetesTerminatedNCT01840189Phase 21 country
- The Effects of Two Brands of Hydrocortisone Injected Intramuscularly Into Deltoid and Thigh MusclesStatus unknownNCT05350020Phase 41 country
- Biomarker(s) for GlucocorticoidsCompletedNCT02152553Not applicable1 country
- Additional Autoimmune Diseases With Type 1 Diabetes in Pediatrics at Diabetes Diagnosis and During Follow-upStatus unknownNCT047899931 country
- Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal InsufficiencyCompletedNCT00915343Phase 2/3
- Spontaneous Coronary Artery Dissection (SCAD) and AutoimmunityCompletedNCT039411841 country
- Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)CompletedNCT02277587Phase 41 country
- Cardiovascular Status in Adrenal InsufficiencyCompletedNCT034263191 country
- Vaginal Prednisone Administration for Prevention of Adrenal CrisisCompletedNCT02689960Phase 2
- Adrenal Function After Living Kidney DonationCompletedNCT002518361 country
- Optimization of the Evaluation of the Adrenal Function After Discontinuation of a Prolonged Therapy With CorticosteroidsTerminatedNCT01053754Not applicable1 country
- Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type ICompletedNCT014528931 country
- Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal FailureStatus unknownNCT01847690Phase 21 country
- Glucocorticoid Treatment in Addison's DiseaseCompletedNCT01063569Phase 2/32 countries
- Revival of Stem Cells in Addison's StudyCompletedNCT01371526Phase 41 country
- Exercise Capacity and Recovery in Addison's DiseaseStatus unknownNCT01657123Not applicable1 country
- Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal InsufficiencyCompletedNCT01450930Phase 21 country
- Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's DiseaseCompletedNCT01271296Not applicable1 country
- Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac SurgeryCompletedNCT00415701Phase 41 country
- The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight RegulationCompletedNCT00688987Not applicable1 country
- Survey in Patients With Chronic Adrenal Insufficiency in GermanyCompletedNCT004441191 country
- Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal InsufficiencyCompletedNCT00004313Phase 3