Adrenal Insufficiency clinical trials
The registry lists 136 studies for Adrenal Insufficiency across more than 10 countries. 27 are recruiting or about to start. 83 of them are mainly about Adrenal Insufficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Adrenoleukodystrophy: 228 studies, 51 open.
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Who runs them
Neurocrine UK Limited (9) · Wuerzburg University Hospital (8) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (5) · University of Wuerzburg (4) · Rigshospitalet, Denmark (4) · Assistance Publique - Hôpitaux de Paris (3) · Shire (3) · Imperial College London (3)
What is being tested here
Drugs under test in Adrenal Insufficiency studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Hydrocortisone | 2 | 6 | 23 |
| Prednisolone | 1 | 1 | 3 |
| Osilodrostat | 1 | 0 | 1 |
| Cabergoline | 1 | 0 | 1 |
| Ravulizumab | 1 | 0 | 1 |
| Cosyntropin | 0 | 1 | 3 |
| Cosyntropin hexaacetate | 0 | 0 | 2 |
| Prednisone | 0 | 0 | 2 |
| Fludrocortisone | 0 | 1 | 2 |
| Dehydroepiandrosterone | 0 | 1 | 2 |
Drug classes tested here Corticosteroids 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) · Duke University
- Dec 2026A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in Children · University Children's Hospital Basel
- Jun 2027Establishment and Clinical Application of Reference Intervals of Salivary Cortisol · Shanghai 6th People's Hospital
- Jul 2027Prevalence of Adrenal Insufficiency and Associated Factors in Rheumatoid Arthritis Patients Using Low-dose Corticosteroids. · Bursa Yuksek Ihtisas Training and Research Hospital
- Aug 2027A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With Ravulizumab · Alexion Pharmaceuticals, Inc.
- Sep 2027Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal Hyperplasia · Assistance Publique - Hôpitaux de Paris
- Oct 2027A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement · University of Michigan
Who these studies take
Of the 20 Adrenal Insufficiency studies recruiting now, 7 (35%) set no upper age limit and 7 (35%) stop at 75 or younger. 5 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (20%) | 4 (20%) |
| 18 | 17 (85%) | 17 (85%) |
| 30 | 15 (75%) | 15 (75%) |
| 40 | 14 (70%) | 14 (70%) |
| 50 | 16 (80%) | 16 (80%) |
| 65 | 16 (80%) | 16 (80%) |
| 75 | 15 (75%) | 15 (75%) |
| 85 | 10 (50%) | 10 (50%) |
Across all 136 studies, recruiting or not: 42% stop at 75 or younger and 29% at 65; 22% take children; 5% are for women only and 7% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Adrenal Insufficiency studies take
Of 27 observational studies under Adrenal Insufficiency, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 31 mo22–98 · 27 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid DisordersOct 20, 2026NCT04374721
Studies
Recruiting first, then most recently updated. Showing 50 of 136. Browse all 136 → or search them.
- Residual Adrenal Function in Addison's DiseaseRecruitingNCT063094981 country
- Natural History Study of Patients With Excess AndrogenRecruitingNCT002501591 country
- Adrenal Diseases in the Population of Modena: A Clinical-Epidemiological Database of Patients Referred to the Adrenal Disorders Outpatient Clinic of the Clinical Unit of Endocrinology at the Modena University Hospital (AOU Modena)RecruitingNCT079201981 country
- Evaluation of Children With Endocrine and Metabolic-Related ConditionsRecruitingNCT027699751 country
- Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid DisordersRecruitingNCT04374721Not applicable1 country
- Prevalence of Adrenal Insufficiency and Associated Factors in Rheumatoid Arthritis Patients Using Low-dose Corticosteroids.RecruitingNCT078663261 country
- A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid ReplacementRecruitingNCT064305281 country
- Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)RecruitingNCT042784042 countries
- Evaluation of Circadian Hormonal Balance: LC-MS/MS Measurement of Salivary and Serum Steroids in Patients With Congenital Adrenal HyperplasiaNot yet recruitingNCT077182301 country
- Hydrocortisone Versus Methylprednisolone for the Treatment of Glucocorticoid-Induced Adrenal InsufficiencyNot yet recruitingNCT07703098Phase 41 country
- Combination Osilodrostat and Cabergoline in Cushing's DiseaseEnrolling by invitationNCT07603466Phase 41 country
- A Swiss Assessment of Hypothalamic-pituitary-adrenal Axis Suppression After Glucocorticoid Therapy for Leukemia and Lymphoblastic Lymphoma in ChildrenRecruitingNCT068615301 country
- Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol SecretionRecruitingNCT069552861 country
- A Study to Investigate OCS Tapering in Adult Participants With Generalized Myasthenia Gravis Treated With RavulizumabRecruitingNCT07221838Phase 44 countries
- Effect of Supplemental Hydrocortisone During Stress in Prednisolone-induced Adrenal InsufficiencyRecruitingNCT05435781Phase 41 country
- Updated Diagnostic Cortisol Values for Adrenal InsufficiencyRecruitingNCT05149638Not applicable1 country
- Hydrocortisone and Placebo in Patients With Symptoms of Adrenal Insufficiency After Cessation of Glucocorticoid TreatmentRecruitingNCT05193396Phase 41 country
- Comparison of Glucocorticoid Tapering Schedules in Rheumatoid ArthritisNot yet recruitingNCT07227428Phase 4
- Establishment and Clinical Application of Reference Intervals of Salivary CortisolRecruitingNCT071681221 country
- Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal DisordersNot yet recruitingNCT06980753Not applicable1 country
- Tolerability and Acceptance of Two Oral Hydrocortisone Compounding Formulation for PediatricsNot yet recruitingNCT06435481Phase 41 country
- Screening for Adrenal Insufficiency During Dermocorticoid Reduction in Bullous Pemphigoid (BP)RecruitingNCT06148090Not applicable1 country
- Diagnosis of Adrenal Insufficiency in Liver Cirrhosis PatientsRecruitingNCT062066551 country
- Hydrocortisone Vs Prednisolone in AI (HYPER-AID)RecruitingNCT036089431 country
- Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological FluidsRecruitingNCT060081841 country
- Feasibility and Validation of the Fluispotter®, a Novel Intravenous System for Serial Blood SamplingNot yet recruitingNCT05931926
- China Adrenal Disease RegistryRecruitingNCT048904441 country
- Post-corticosteroid Insufficiency: Search for a Threshold Value for Cortisol at 8 Hours, Prospective StudyCompletedNCT06208098Not applicable1 country
- Adrenal Function in Critical IllnessCompletedNCT001567671 country
- Treatment of Adrenal Insufficiency in ChildrenCompletedNCT02720952Phase 31 country
- Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAHCompletedNCT01735617Phase 21 country
- An Investigational Study of HydrocortisoneCompletedNCT01960530Phase 11 country
- Extension Study for Patients Entered Into Study Infacort 003CompletedNCT02733367Phase 31 country
- A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female SubjectsCompletedNCT03311932Phase 11 country
- Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral AdministrationCompletedNCT03178214Phase 11 country
- An Open Label Study in Healthy Volunteers to Compare Chronocort® to HydrocortisoneCompletedNCT03019614Phase 1
- A Two-part, Study to Compare the Pharmacokinetics and Dose Proportionality of up to 6 Chronocort FormulationsCompletedNCT03051893Phase 1
- A Study of Chronocort® Versus Cortef ® in Healthy Adult Male SubjectsCompletedNCT03343327Phase 11 country
- Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe SepsisWithdrawnNCT00368381Phase 4
- A Study to Evaluate Administration of SBT101 Gene Therapy in Adult Patients With Adrenomyeloneuropathy (AMN)TerminatedNCT05394064Phase 1/22 countries
- Treatment Study in Patients Treated With Both Insulin & HydrocortisoneWithdrawnNCT05716607Not applicable1 country
- Genomic and Metabolomic Markers Reflecting the Complications of Hypercortisolism (CUSHINGOMICS)Active, not recruitingNCT04840693Not applicable1 country
- Low Dose of Hydrocortisone and Fludrocortisone in Adult Cardiogenic Shock.CompletedNCT03773822Phase 31 country
- Glucagon-like Peptide-1 Receptor Agnoists for the Assessment of Adrenal FunctionCompletedNCT06608433Not applicable1 country
- Study of Disease Progression in Adults With Inherited Forms of Spastic ParaplegiaTerminatedNCT050088743 countries
- Improved Diagnostics and Monitoring of Polymyalgia RheumaticaActive, not recruitingNCT045195801 country
- Defining the Mechanisms Underlying Adrenal Insufficiency in CirrhosisCompletedNCT046423911 country
- Self-management in Patients With Adrenal Insufficiency.Active, not recruitingNCT06637722
- A European Post-Authorisation Observational Study (Registry) of Patients With Chronic Adrenal Insufficiency (AI)TerminatedNCT016613875 countries
- Rheumatoid Arthritis Adrenal Recovery StudyCompletedNCT032948761 country