An interventional study of 60-Minute Auditory Fatigue Listening Task in Auditory Fatigue and Central Auditory Processing, sponsored by Istanbul Nisantasi University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-12.
Sponsored by Istanbul Nisantasi University · Not applicable, Interventional, and Basic science
Among 333 studies in Fatigue with a site in Turkey — 50 open to participants now, 56 under way, none of them phase 3. Fatigue · Turkey.
Among the 333 studies in Fatigue with a site in Turkey, this one is the 104th largest by planned enrollment of the 253 interventional ones that give a count, is one of 42 that started in 2026, is one of 250 with no phase, reaches primary completion later than 54 of the 55 other live ones, and was the 333rd registered.
2,232 studies on the registry are indexed under Fatigue; 428 are open to participants now.
Browse Fatigue studies →50 of the 333 studies in Fatigue with a site in Turkey are open now. Recruiting first, the newest first:
University of Gaziantep · Sites in Turkey
Ages 18–65
Kahramanmaras Sutcu Imam University · Sites in Turkey
Ages 18+
Afyonkarahisar Health Sciences University · Sites in Turkey
Ages 18–65
Firat University · Sites in Turkey
Ages 18+
Artvin Coruh University · Sites in Turkey
Ages 30–50 · Women only
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 240 Fatigue studies recruiting now, 111 (46%) set no upper age limit and 99 (41%) stop at 75 or younger; 23 take children under 18; 73 take healthy volunteers.
This study: 18 Years to 40 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
333 studies; the count open now beside each. This study's row is marked.
A study in two phases is counted once above. Listed by phase, each with its combined phases: Phase 1 1 · Phase 2 2 · Phase 3 1
First in 2010; this study’s year is marked. 42 started in 2026.
By drug class, each counting the studies that test any of its medicines:
This study's planned enrollment of 60 is above the median of 54 across 1,760 interventional studies indexed under Fatigue.
Median enrollment 60 across the 253 interventional studies, 83 across the 80 observational. Of the 256 that completed or were terminated, 3 (1%) have results posted.
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3 of 333 have an industry lead sponsor. The 10 most frequent:
Istanbul Nisantasi University is the lead sponsor of 22 studies on the registry; 8 are open to participants now.
Istanbul Nisantasi University has 1 study filed under Fatigue — fewer than ten, so there is no comparison to draw.
12 of the studies in Fatigue with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07619209Ankara UniversityThe Effect of Progressive Muscle Relaxation and Deep Breathing Exercises Applied to Palliative Care Cancer Patients on Dyspnea, Fatigue, and Self-Care Behaviors | 2026-11 |
| NCT07832721Volkan GokmenSleep, Mindfulness, and Shift-Level Safety Performance in Perianesthesia Nurses | 2026-12 |
| NCT07325396Yeditepe UniversityNeuromuscular Training in Professional Esports Players | 2026-12-01 |
| NCT07842731Atılım UniversityInvestigation of the Prevalence of Sarcopenia and Dynapenia According to Disease Stage in Patients With Multiple Sclerosis and Evaluation of the Relationship Between Sarcopenia Severity and Clinical and Functional Parameters | 2026-12-10 |
| NCT07926763University of GaziantepInspiratory Muscle Training Plus Cold Water Immersion After Muscle-Damaging Exercise | 2026-12-31 |
Add all 12 to your calendar (.ics) → With an account.
Among the 333 studies in Fatigue with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study aims to investigate how auditory fatigue caused by a prolonged and demanding listening task affects central auditory processing abilities in adults with normal hearing. Central auditory processing refers to how the brain processes and interprets sounds, including the ability to recognize differences in sound timing and patterns.
A total of 60 adults aged 18-40 years will participate. Participants will be divided into two groups based on their occupational listening demands. One group will include 30 individuals working in professions that require frequent and sustained verbal communication, such as simultaneous interpreters, speech and language therapists, special education teachers, and psychologists. The comparison group will include 30 individuals whose occupations do not require intensive and continuous verbal communication.
All participants will undergo hearing assessments and central auditory processing tests before and after a 60-minute listening task involving Turkish speech materials presented with background noise from multiple speakers. Participants will also rate their perceived auditory fatigue, listening effort, and task demands before and after the listening task.
The study will examine changes in auditory processing performance following the listening task and determine whether these changes differ between the two occupational groups. The findings may help researchers and clinicians better understand how auditory fatigue influences auditory processing test results.
Central auditory processing involves the neural mechanisms responsible for analyzing and interpreting auditory information beyond peripheral hearing sensitivity. Temporal resolution and temporal pattern recognition are important components of central auditory processing and can be assessed using behavioral auditory tests.
Prolonged listening under demanding conditions may increase listening effort and the use of cognitive resources, potentially contributing to auditory fatigue. Although previous research has investigated listening effort and fatigue in relation to speech perception, cognitive demands, and subjective experiences, evidence regarding the effects of experimentally induced acute auditory fatigue on behavioral central auditory processing performance remains limited.
This study is designed as a non-randomized, quasi-experimental, pretest-posttest investigation involving two groups with different occupational listening demands. The study will include 60 adults aged 18-40 years with normal peripheral hearing, with 30 participants in each group.
The first group will consist of individuals employed in occupations requiring sustained verbal communication, active speech listening, and auditory attention, including simultaneous interpreters, speech and language therapists, special education teachers, and psychologists conducting regular client consultations. The comparison group will consist of individuals whose occupational responsibilities do not require intensive and continuous verbal communication. The groups will be matched as closely as possible in terms of age, sex, and educational level.
Before the experimental listening task, participants will undergo otoscopic examination, tympanometry, pure-tone audiometry, and speech audiometry to assess peripheral hearing status and determine eligibility.
Central auditory processing performance will be assessed using three behavioral tests:
Participants will also complete Visual Analog Scale (VAS) assessments of perceived auditory fatigue, listening effort, and task demands.
Following baseline assessments, all participants will complete a standardized 60-minute experimental listening task developed using Turkish Hearing in Noise Test (HINT-TR) speech materials presented with multi-talker babble noise. The task is intended to induce acute auditory fatigue under controlled listening conditions.
Immediately after the listening task, the GIN, FPT, and DPT assessments will be repeated. Subjective auditory fatigue, listening effort, and perceived task demands will also be reassessed using VAS measures.
The primary analyses will examine changes in central auditory processing performance before and after the listening task and evaluate whether these changes differ between occupational groups. Group, time, and group-by-time interaction effects will be investigated using mixed-design repeated-measures analysis of variance when statistical assumptions are satisfied. Associations between changes in subjective measures and behavioral auditory processing performance will also be examined using appropriate correlation analyses.
All participants will undergo the same standardized assessment procedures and experimental listening protocol. Familiarization procedures and standardized testing conditions will be used to reduce potential measurement variability and practice effects.
The study is expected to contribute to understanding the relationship between experimentally induced auditory fatigue and central auditory processing performance and may provide useful information for interpreting behavioral central auditory processing assessments in clinical and research settings.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
This arm will include 30 adults aged 18-40 years with normal peripheral hearing who work in occupations requiring sustained verbal communication, active speech listening, and auditory attention. Participants will include simultaneous interpreters, speech and language therapists, special education teachers, and psychologists conducting regular client consultations. All participants will complete a standardized 60-minute experimental auditory fatigue listening task. Central auditory processing performance will be assessed using the Gaps-in-Noise Test (GIN), Frequency Pattern Test (FPT), and Duration Pattern Test (DPT) before and after the listening task. Perceived auditory fatigue, listening effort, and task demands will also be evaluated using Visual Analog Scales (VAS).
Behavioral: 60-Minute Auditory Fatigue Listening Task
This arm will include 30 adults aged 18-40 years with normal peripheral hearing whose occupations do not require intensive and sustained verbal communication or continuous active speech listening. Participants will be selected to achieve comparable age, sex, and educational characteristics between occupational groups where possible. All participants will complete the same standardized 60-minute experimental auditory fatigue listening task administered to the high occupational listening demands group. Central auditory processing performance will be assessed using the Gaps-in-Noise Test (GIN), Frequency Pattern Test (FPT), and Duration Pattern Test (DPT) before and after the listening task. Perceived auditory fatigue, listening effort, and task demands will also be evaluated using Visual Analog Scales (VAS).
Behavioral: 60-Minute Auditory Fatigue Listening Task
All participants will complete a standardized 60-minute experimental listening task designed to induce acute auditory fatigue. The task will involve sustained listening to Turkish Hearing in Noise Test (HINT-TR) speech materials presented with multi-talker babble noise. The same listening protocol will be administered to participants in both occupational groups under standardized conditions. The intervention will be performed once, following baseline auditory assessments. Immediately after the task, central auditory processing performance will be reassessed using the GIN, FPT, and DPT. Subjective auditory fatigue, listening effort, and perceived task demands will also be evaluated using Visual Analog Scales (VAS) before and after the intervention.
Gaps-in-Noise Test (GIN)
Temporal resolution will be assessed using the Gaps-in-Noise (GIN) Test. The outcome will be the change in gap detection threshold, measured in milliseconds (ms), calculated as the post-intervention threshold minus the baseline threshold. Lower thresholds indicate better temporal resolution. Changes will be compared between the two occupational groups.
Time frame: Baseline (before the listening task) and immediately after the 60-minute listening task, during the same study visit.
Frequency Pattern Test (FPT)
Temporal pattern recognition based on frequency variations will be assessed using the Frequency Pattern Test (FPT). Performance will be expressed as the percentage of correctly identified frequency patterns, ranging from 0% to 100%. The outcome will be calculated as the post-intervention percentage minus the baseline percentage. Higher percentages indicate better performance. Changes will be compared between occupational groups.
Time frame: Baseline (before the listening task) and immediately after the 60-minute listening task, during the same study visit.
Duration Pattern Test (DPT)
Temporal pattern recognition based on sound duration will be assessed using the Duration Pattern Test (DPT). Performance will be expressed as the percentage of correctly identified duration patterns, ranging from 0% to 100%. The outcome will be calculated as the post-intervention percentage minus the baseline percentage. Higher percentages indicate better performance. Changes will be compared between occupational groups.
Time frame: Baseline (before the listening task) and immediately after the 60-minute listening task, during the same study visit.
Perceived Auditory Fatigue (VAS)
Perceived auditory fatigue will be assessed using a 100-mm Visual Analog Scale (VAS) before and immediately after the experimental listening task. Participants will rate their perceived level of auditory fatigue on a continuous scale ranging from 0 mm (no auditory fatigue at all) to 100 mm (extreme auditory fatigue). Higher scores indicate greater perceived auditory fatigue. The outcome will be calculated as the post-intervention VAS score minus the baseline VAS score, expressed in millimeters (mm). Positive change scores indicate an increase in perceived auditory fatigue following the listening task.
Time frame: Baseline (before the listening task) and immediately after the 60-minute listening task, during the same study visit.
Perceived Listening Effort (VAS)
Perceived listening effort will be assessed using a 100-mm Visual Analog Scale (VAS) before and immediately after the experimental listening task. Participants will rate their perceived level of listening effort on a continuous scale ranging from 0 mm (no listening effort at all) to 100 mm (extremely high listening effort). Higher scores indicate greater perceived listening effort. The outcome will be calculated as the post-intervention VAS score minus the baseline VAS score, expressed in millimeters (mm). Positive change scores indicate an increase in perceived listening effort following the listening task.
Time frame: Baseline (before the listening task) and immediately after the 60-minute listening task, during the same study visit.
Plan to share: No — Individual participant data will not be shared with researchers outside the study team. Study data will be coded and securely stored in accordance with the approved research protocol and applicable data protection regulations. Only authorized members of the research team will have access to individual-level data. Study findings may be published in aggregate form without identifying individual participants.
Start is estimated for Nov 2026; primary completion for Oct 2027, 11 months later.
Of 936 non-industry interventional studies with no phase under Fatigue, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 27. This study's planned 11 months is close to that.
Counting every sponsor, half of 989 studies reached it within 11 months; a quarter within 5 and three quarters within 27.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Istanbul Nisantasi University