An interventional study of Juniper Essential Oil Inhalation and Thyme Essential Oil Inhalation in Examination Anxiety, Test Anxiety and Situational Anxiety, sponsored by Gulbahar Boyuk Ozcan. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-06.
Sponsored by Gulbahar Boyuk Ozcan · Not applicable, Interventional, and Treatment
Among 39 studies in Stress, Psychological with a site in Turkey — 9 open to participants now, 12 under way, none of them phase 3. Stress, Psychological · Turkey.
Among the 39 studies in Stress, Psychological with a site in Turkey, this one is the 17th largest by enrollment of the 33 interventional ones that give a count, is one of 7 that started in 2024, is one of 33 with no phase, and was the 19th registered.
848 studies on the registry are indexed under Stress, Psychological; 139 are open to participants now.
Browse Stress, Psychological studies →9 of the 39 studies in Stress, Psychological with a site in Turkey are open now. Recruiting first, the newest first:
Istanbul University · Sites in Turkey
Ages 18+
Mustafa Kemal University · Sites in Turkey
Ages 20–30 · Healthy volunteers
Fidan Balkaya · Sites in Turkey
Ages 18+ · Women only · Healthy volunteers
Süleyman Korkusuz · Sites in Turkey
Healthy volunteers
Kilis 7 Aralik University · Sites in Turkey
Ages 0 days–28 days · Healthy volunteers
A study can be open while its sites in Turkey have not opened yet or have stopped. Only those recruiting at a site in Turkey →
Of the 75 Stress, Psychological studies recruiting now, 34 (45%) set no upper age limit and 37 (49%) stop at 75 or younger; 14 take children under 18; 49 take healthy volunteers.
This study: 18 Years to 25 Years · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
39 studies; the count open now beside each. This study's row is marked.
First in 2018; this study’s year is marked. 7 started in 2024.
This study's enrollment of 80 is close to the median of 84 across 692 interventional studies indexed under Stress, Psychological.
Median enrollment 80 across the 33 interventional studies, 72 across the 6 observational. Of the 27 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 39 has an industry lead sponsor. The 10 most frequent:
Gulbahar Boyuk Ozcan is the lead sponsor of 2 studies on the registry; none are open to participants now.
Gulbahar Boyuk Ozcan has 2 studies filed under Stress, Psychological — fewer than ten, so there is no comparison to draw.
5 of the studies in Stress, Psychological with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07727434Istanbul UniversityStress and Anxiety Before Biopsy, After Biopsy Results, and During Treatment in Patients With Suspected Bone or Soft Tissue Cancer | 2026-12-20 |
| NCT07906743Fidan BalkayaMandala Coloring in Late Pregnancy | 2027-01-05 |
| NCT07842744Süleyman KorkusuzMultiple Sclerosis Severity and Caregiver Health Outcomes | 2027-01-20 |
| NCT07644949Istanbul Medeniyet UniversitySelf-Help Plus (SH+) for Stress Reduction in Social Service Workers: A Pilot RCT | 2027-02 |
| NCT07666594Tugba Civi KaraaslanMobile App-Based Yoga and Meditation in Rheumatoid Arthritis | 2027-05 |
Add all 5 to your calendar (.ics) → With an account.
Among the 39 studies in Stress, Psychological with a site in Turkey, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This clinical study investigates whether inhalation of juniper and thyme essential oils can reduce anxiety and related physiological symptoms in medical students during exam periods.
Eighty healthy university students, aged 18 to 25, will participate in this trial. Participants will inhale either juniper or thyme oil via aromatherapy before taking an academic examination.
The study will assess the effects on anxiety-related hormones (asprosin, cortisol, CREB) using saliva samples, and will measure physiological parameters such as heart rate, blood pressure, oxygen saturation, and body temperature before and after aroma inhalation.
This study aims to determine whether short-term exposure to essential oils can safely and effectively reduce exam-induced anxiety.
Exam anxiety is a common challenge among university students, particularly those in high-pressure fields like medicine. Anxiety negatively impacts cognitive performance and physiological balance, often raising stress hormone levels and affecting cardiovascular indicators.
This interventional study is designed to explore the therapeutic potential of aromatherapy using two essential oils-juniper (Juniperus communis) and thyme (Thymus vulgaris)-which are known for their anxiolytic and calming properties.
The study will be conducted at a medical faculty in Turkey during final examination periods. Participants will serve as their own controls, undergoing saliva collection and physiological monitoring before and after a brief aroma inhalation session.
Salivary samples will be analyzed for asprosin, cyclic AMP response element-binding protein (CREB), and cortisol concentrations using ELISA. Physiological measures such as systolic and diastolic blood pressure, heart rate, SpO₂, and body temperature will be monitored to assess autonomic nervous system response.
The findings of this study may provide new insights into non-pharmacological interventions for managing situational anxiety in academic and clinical settings. No serious risks are anticipated, as essential oils will be administered via inhalation in low concentrations for a limited duration under controlled conditions.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Being willing to participate in the research, being a first-year medical student, being over 18 years old, being healthy
Exclusion Criteria:
Having a communication barrier, incomplete form filling, menstruation in girls, allergies to thyme and juniper oil scents, any side effects during the application, having a cardiovascular disease, being pregnant, having any respiratory system disease (asthma, , etc.), having a condition that prevents smelling, using any medication that affects heart rate and blood pressure, or having a psychiatric disease.
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants inhale juniper essential oil for 15 minutes prior to the exam. Physiological and hormonal measurements are taken immediately before and after the inhalation.
Other: Juniper Essential Oil Inhalation
Participants inhale thyme essential oil for 15 minutes prior to the exam. Physiological and hormonal measurements are taken immediately before and after the inhalation.
Other: Thyme Essential Oil Inhalation
Participants inhale 2 drops of juniper essential oil via an inhaler for 15 minutes prior to the exam session to evaluate effects on anxiety-related parameters.
Participants inhale 2 drops of thyme essential oil via an inhaler for 15 minutes prior to the exam session to evaluate effects on anxiety-related parameters.
Change in Salivary Cortisol Levels
Saliva samples will be collected immediately before and 15 minutes after aroma inhalation to measure cortisol levels using the ELISA method.
Time frame: Baseline and 15 minutes post-inhalation
Change in Salivary Asprosin Levels
Saliva samples will be analyzed using the ELISA method to measure asprosin levels, serving as a physiological stress indicator.
Time frame: Baseline and 15 minutes post-inhalation
Change in Salivary CREB Levels
Salivary CREB concentrations will be measured using the ELISA method to evaluate biochemical stress responses.
Time frame: Baseline and 15 minutes post-inhalation
Change in Systolic and Diastolic Blood Pressure
Blood pressure will be measured using an automated cuff to evaluate autonomic responses to aromatherapy.
Time frame: Baseline and immediately post-inhalation
Change in Heart Rate and Oxygen Saturation
Heart rate and oxygen saturation (SpO₂) will be monitored using a pulse oximeter.
Time frame: Baseline and immediately post-inhalation
Plan to share: No — The individual participant data (IPD) will not be shared due to ethical considerations and institutional restrictions.
No publications or documents are linked to this record.
Ran from Jul 2024 to primary completion in Jul 2024, 0 months.
Of 459 non-industry interventional studies with no phase under Stress, Psychological, half reached primary completion within 13 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 26. This study's 0 months is below that.
Counting every sponsor, half of 472 studies reached it within 13 months; a quarter within 5 and three quarters within 26.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Gulbahar Boyuk Ozcan