An observational study in ADHD, sponsored by National Taiwan University Hospital. Recruiting at 1 site in Taiwan. Open to participants aged 6 Years to 16 Years. Per ClinicalTrials.gov, last updated 2026-10-28.
Sponsored by National Taiwan University Hospital · Observational
To build a multimodal model combining neuropsychological, neurophysiological, and metabolomic measures to identify biomarkers predicting MPH-induced adverse effects and their underlying mechanisms, supporting individualized risk assessment in clinical practice.
1,817 studies on the registry are indexed under Attention Deficit Disorder with Hyperactivity; 296 are open to participants now.
This study's planned enrollment of 90 is below the median of 127 across 329 observational studies indexed under Attention Deficit Disorder with Hyperactivity.
Browse Attention Deficit Disorder with Hyperactivity studies →National Taiwan University Hospital is the lead sponsor of 2,615 studies on the registry; 576 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
Counted across the registry records on this site, refreshed daily.
90 medication-naïve children with ADHD aged 6 to 16 years will be recruited in this project.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Subjects with clinical diagnosis of ADHD according to the DSM-V criteria
Drug: methylphenidate
The patients with ADHD will receive 16-week treatment with methylphenidate.
Questionnaire
Parents assisted in filling out the Barkley's Side Effects Rating Scale (SERS). Each question in this questionnaire is scaled from 0 to 9. The higher the score on each question, the more severe the symptom.
Time frame: 5 minutes
Diagnostic interview
We will interview all the participants and their parents to examine whether the participants have any psychiatric disorder by employing the Kiddie Epidemiologic version of the Schedule for Affective Disorders and Schizophrenia (K-SADS-E).
Time frame: 1 hour
ADHD symptoms
Subjects will be interviewed by ADHD rating scale , which consists of 18 items to measure the symptomatology of ADHD . Each question in this questionnaire is scaled from 0 to 3. The higher the total score, the more severe the symptoms.
Time frame: 15 minutes
Neurobiological assessments
Resting state EEG will be recorded in NTUH ERP lab. The EEG will be processed for functional connectivity indices between regions are calculated using the magnitude squared coherence (Coh) in the delta(delta)/theta(theta)/alpha(alpha)/beta(beta) frequency bands and the nonlinear index (L) of generalized synchronization.
Time frame: 10 minutes
Neurobiological assessments
Resting state EEG will be recorded in NTUH ERP lab. Phase transfer entropy (PTE) will be used to construct the effective connectivity. The topological properties of networks and flow gain are measured separately in four bands (delta, theta, alpha, and beta).
Time frame: 10 minutes
Neurobiological assessments
Resting state EEG will be recorded in NTUH ERP lab. We will perform Fast Fourier Transform using the pwelch algorithm, with a 128 sample triangular window, to obtain time-frequency domain measures. Mean spectral estimates in various power bands are computed. As a measure of intraindividual variability in neural activity, the standard deviation of the power in each 2-second trial is calculated for each band for each participant.
Time frame: 10 minutes
Neurobiological assessments
Auditory MMN/P3a (task-free ERP) will be recorded in NTUH ERP.
Time frame: 30 minutes
Neurobiological assessments
dichotic continuous performance task(DCPT, task-related ERP modified from Conner's CATA) will be recorded in NTUH ERP lab.
Time frame: 20 minutes
liquid chromatography-mass spectrometry
Whole blood samples will be collected after 8 hours of fasting. The investigators will employ liquid chromatography coupled to mass spectrometry (LC/MS) to conduct the experiments of metabolomic profiling of the serum at the Metabolomics Core Laboratory, National Taiwan University.
Time frame: 5 minutes
Neuropsychological testing
Subjects will be assessed by the WISC-V(Wechsler Intelligence Scale for Children),WISC-V scores between 90 and 109 represent moderate general intelligence, and higher scores represent relatively better cognitive function.
Time frame: 1.5 hours
Started Aug 2026 (actual). Primary completion is estimated for Jul 2029, 35 months after the start.
Of 85 non-industry observational studies under Attention Deficit Disorder with Hyperactivity, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 18 and three quarters within 69. This study's planned 35 months is close to that.
Counting every sponsor, half of 95 studies reached it within 35 months; a quarter within 20 and three quarters within 69.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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