An observational study in Nonspecific Chronic Low Back Pain, sponsored by Oregon Health and Science University. Completed at 1 site in United States. Open to participants aged 30 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-27.
Sponsored by Oregon Health and Science University · Observational
Among 711 studies in Low Back Pain with a site in United States — 99 open to participants now, 125 under way, 3 of them phase 3. Low Back Pain · United States.
Among the 711 studies in Low Back Pain with a site in United States, this one is the 67th largest by enrollment of the 84 observational ones, is one of 45 that started in 2019, is one of 86 observational ones, and was the 459th registered.
2,922 studies on the registry are indexed under Low Back Pain; 580 are open to participants now.
This study's enrollment of 26 is below the median of 100 across 481 observational studies indexed under Low Back Pain.
Browse Low Back Pain studies →99 of the 711 studies in Low Back Pain with a site in United States are open now, in 3 countries. Each count lists the studies.
Of the 333 Low Back Pain studies recruiting now, 92 (28%) set no upper age limit and 211 (63%) stop at 75 or younger; 8 take children under 18; 46 take healthy volunteers.
This study: 30 Years to 70 Years · all sexes · healthy volunteers too.
The full table on the hub →711 studies; the count open now beside each. This study's row is marked.
First in 1977; this study’s year is marked. 45 started in 2019.
Median enrollment 78 across the 623 interventional studies, 89 across the 84 observational. Of the 512 that completed or were terminated, 206 (40%) have results posted.
156 of 711 have an industry lead sponsor. The 10 most frequent:
Oregon Health and Science University is the lead sponsor of 696 studies on the registry; 131 are open to participants now.
Of its 52 completed or terminated interventional studies of FDA-regulated products, 39 (75%) have results posted.
Oregon Health and Science University has 2 studies filed under Low Back Pain — fewer than ten, so there is no comparison to draw.
51 of the studies in Low Back Pain with a site in United States that are under way reach primary completion within a year, 1 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07254806Phase 3DiscGenics, Inc.A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease | 2027-11-24 |
| NCT07125027National University of Natural MedicineA Multicomponent Intervention for Patients With Lumbosacral Radiculopathy: Move-MORE | 2026-11 |
| NCT07652944Joe X. ZhangTrial to Test the Efficacy of Using Magnetic Fields to Stimulate the Back to Treat Chronic Lower Back Pain. | 2026-11 |
| NCT04730700University of Kansas Medical CenterEvaluation of Multi-Tined Expandable Electrode (MEE) Efficacy and Safety in Treatment of Lumbar Facet Arthropathy by Radiofrequency Neurotomies Compared to Conservative Medical Management. | 2026-11-30 |
| NCT06007976Mayo ClinicLLLT to Reduce Low Back Pain | 2026-12 |
Among the 711 studies in Low Back Pain with a site in United States, from their registry updates:
The purpose of this cross-sectional study is to compare cortical reactivity and cognitive-affective regulation in response to experimental pain between healthy controls and individuals with non-specific chronic low back pain.
Aim 1:To compare amplitudes of pain-related evoked potentials during electrical paired-pulse stimulation between individuals with non-specific chronic low back pain and healthy controls.
Aim 2: To compare differences in pain habituation between individuals with non-specific chronic low back pain and healthy controls.
Aim 3: To compare cognitive-affective regulation between individuals with non-specific chronic low back pain and healthy controls.
Non-specific chronic low back pain (cLBP). Human participants with non-specific cLBP will be studied. Nonspecific cLBP is a broadly used-term to suggest that patient-reported pain cannot be explained by known tissue damage, inflammatory responses, or neuropathy. Enrolled participants will have experienced pain that has persisted for longer than 3 months and for at least half of the days during the past 6 months. Further, pain will interfere with activities of daily life and participation in social roles.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Healthy individuals ages 30-70 years old.
Individuals ages 30-70 years old with nonspecific chronic low back pain for at least 3 months with pain on at least half the days during the last 6 months.
Pain-Related Evoked Potentials (amplitude)
Cortical pain habituation is acquired via pain-related evoked potentials (PREPs): time-locked neural responses to painful electrical stimuli derived from an ongoing EEG. Electrical pulses are delivered using a constant current via a custom-built concentric electrode taped onto the radial side of the dorsum of the non-dominate hand. The electrode is connected to the electrical stimulator, Digitimer DS7A (Digitimer Ltd, Welwyn Garden City, Hertfordshire, UK), which provides standardized, precisely-delivered electrical stimuli. EEG is collected using a BioSemi 32-channel ActiveTwo system using active-sensor Ag-AgCl electrodes (BioSemi, Amsterdam).
Time frame: at time of subject enrollment
Pain-Related Evoked Potentials (Habituation)
Pain habitation is measured by change of PREP amplitudes between the first and third block of electrical stimulation.
Time frame: at time of subject enrollment
Pain Catastrophizing Scale
A psychological assessment tool designed to measure the extent of catastrophic thinking related to pain. It evaluates how individuals perceive and react to pain, focusing on their thoughts and feelings during painful experiences.
Time frame: At time of subject enrollment
Five Facets of Mindfulness Questionnaire
Widely used tool designed to assess an individual's level of mindfulness across five distinct dimensions: Observing: Noticing or attending to internal and external experiences, such as thoughts, feelings, and sensations. Describing: The ability to put feelings and experiences into words. Acting with Awareness: Engaging in activities with full attention rather than on autopilot. Non-judging of Inner Experience: Accepting thoughts and feelings without criticism or evaluation. Non-reactivity to Inner Experience: Allowing thoughts and feelings to come and go without getting caught up in them.
Time frame: At time of subject enrollment
Multidimensional Assessment of Interoceptive Awareness
An adult self-report measure that assesses interoceptive awareness, or how individuals perceive, interpret, and respond to internal bodily sensations.
Time frame: At time of subject enrollment
Plan to share: Yes — Individual participant data that underlie the results reported in the article, after de-identification will be shared. Study protocols, statistical analyses plan, and the analytic code will be provided beginning 3 months after and ending 5 years following the article publication to individuals who provide a methodologically sound proposal for any purpose.Proposals should be directed to colgand@ohsu.edu. To gain access, requestors will need to sign a data access agreement.
Supporting information: Study protocol, Statistical analysis plan, Informed consent form, Clinical study report, Analytic code
Time frame: 3 months after publication and up to five years following publication.
Access criteria: To individuals who provide a methodologically sound proposal for any purpose.
No publications or documents are linked to this record.
Ran from Apr 2019 to primary completion in Apr 2022, 36 months.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Jun 2022. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Oregon Health and Science University →