ClinicalTrials.gg
Not yet recruitingNCT07756619Updated Aug 17, 2026

Neuromuscular Stimulation in the Distal Radius Fractures

An interventional study of Traditional Exercises and Neuromuscular Stimulation in Distal Radius Fractures, sponsored by Kirsehir Ahi Evran Universitesi. Not yet recruiting. Open to participants aged 18 Years to 90 Years. Per ClinicalTrials.gov, last updated 2026-08-17.

Sponsored by Kirsehir Ahi Evran Universitesi · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
36
Allocation
Randomized
Ages
18 Years to 90 Years
Sex
All
01

Study summary

Distal radius fractures (DRFs) are fractures affecting the wrist and occurring in the distal portion of the radius bone. DRFs can also be classified as Colles, Barton, Smith, and Hutchinson/Chauffeur fractures according to the characteristics of the fracture. The incidence of these fractures shows a bimodal distribution. In young adults, distal radius fractures occur more often as a result of high-energy traumas (e.g., traffic accidents or impacts during contact sports), while in older adults, especially during winter months, low-energy falls from standing height (falling onto an outstretched hand) are a more common cause.

Read the detailed description

Distal radius fractures (DRFs) can be treated surgically, or conservatively with closed reduction followed by immobilization with a cast. Fractures with minimal displacement are treated conservatively in approximately one-third of cases. The standard immobilization period for DRFs is six weeks to allow for callus formation and healing of the bone and soft tissues. During plaster cast application, the standard practice is to ensure the preservation of the range of motion of the upper extremity joints above and below the cast.

Recent studies have investigated shorter immobilization periods to allow for earlier mobilization. In studies comparing plaster cast applications that can be as short as 10 days with the standard duration (approximately 6 weeks), no significant difference was found between the groups in terms of patient-reported functional outcomes, pain levels, development of Complex Regional Pain Syndrome (CRPS), secondary displacement or complications in follow-ups up to nine months after the fracture. In DRF, regardless of the treatment method, the recovery of motor functions, strength and mobility generally takes three to six months. In a small percentage of patients, mild disability and pain may persist even years after a distal radius fracture (DRF). As a result of DRF, individuals experience a decrease in wrist joint range of motion (ROM), a decrease in grip strength, impairment of hand skills (hand agility/dexterity), and an increase in pain. The main aim of rehabilitation is to eliminate these disorders using physical agents (modalities), manual therapy and exercise programs. Exercise programs include exercises aimed at improving range of motion, hand skills and muscle strength. Rehabilitation makes significant contributions to reducing functional losses, accelerating the recovery process and shortening the time individuals are away from work .Neuromuscular Electrical Stimulation (NMES) is a useful treatment method for preserving, maintaining, and restoring neuromuscular function losses resulting from disuse. One of the significant advantages of NMES is that the devices are easily purchased for individual use and can be applied at home. NMES is used in the treatment of paresis, contractures, and spasticity in the upper extremities after stroke. Studies on the upper extremities have shown that NMES application provides improvements in muscle strength, range of motion (ROM), functional performance, and cortical activation. Reduction in upper extremity spasticity and pain has also been reported. In knee osteoarthritis (OA), NMES applications have resulted in improved muscle strength and function along with reduced pain and stiffness. Furthermore, NMES applied after knee and hip replacement surgeries has been shown to increase muscle strength and functional capacity, reduce muscle atrophy, and decrease pain. Due to the positive effects of NMES on muscle strength, blood circulation, and hand edema in the early stages, this study will investigate the effects of neuromuscular stimulation on pain, grip strength, edema, range of motion, and functionality in the rehabilitation of operated distal radius fractures. This approach is expected to provide an innovative contribution to the classical rehabilitation protocols used in distal radius fractures.

02

Conditions studied

  • Distal Radius Fractures

Keywords

  • Wrist Fractures
  • pain
  • distal radius fractures
  • electrotherapy
03

In context

Wrist Fractures

330 studies on the registry are indexed under Wrist Fractures; 73 are open to participants now.

This study's planned enrollment of 36 is below the median of 62 across 265 interventional studies indexed under Wrist Fractures.

Browse Wrist Fractures studies →

Lead sponsor

Kirsehir Ahi Evran Universitesi is the lead sponsor of 138 studies on the registry; 52 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients who underwent open reduction and volar plate surgery due to distal radius fracture (DRF) evaluated with plain radiography and CT scans.

Exclusion criteria

Exclusion Criteria:

  • Polytrauma
  • Surgical intervention other than volar plate
  • History of surgery on the affected extremity
  • Injury to multiple anatomical sites in the affected extremity
  • Hemiplegia or contracture in the affected extremity
  • Major complications such as postoperative neurovascular injury and hematoma
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
36 participants (estimated)

Study arms

  • Active comparator
    Traditional Treatment

    Individuals in this group will undergo passive, active-assisted, and active hand and wrist joint exercises. The exercises will be tailored to protocols reported as safe and effective in the literature.

    Other: Traditional Exercises

  • Experimental
    Neuromuscular Stimulation

    Individuals in this group will receive neuromuscular stimulation in addition to the Traditional Treatment protocol.

    Other: Traditional Exercises · Other: Neuromuscular Stimulation

Interventions

  • OtherTraditional Exercises

    active joint movements of the hand and wrist, passive, active-assisted and active stretching exercises

  • OtherNeuromuscular Stimulation

    Neuromuscular stimulation will be applied to the m. flexor digitorum superficialis and m. flexor digitorum profundus muscles.

06

What researchers measure

Primary outcomes

  1. Visual analog scale

    A visual analog scale will be used to evaluate the patients' current pain severity. This scale is one of the frequently preferred scales to evaluate the pain intensity of patients during rest, activity and night. The scale has a 10 cm long line where the patient can mark the intensity of pain. The patient will be asked to indicate the degree of pain intensity between no pain (left part) and unbearable pain (right part) of the line.

    Time frame: Baseline

  2. Visual analog scale

    A visual analog scale will be used to evaluate the patients' current pain severity. This scale is one of the frequently preferred scales to evaluate the pain intensity of patients during rest, activity and night. The scale has a 10 cm long line where the patient can mark the intensity of pain. The patient will be asked to indicate the degree of pain intensity between no pain (left part) and unbearable pain (right part) of the line.

    Time frame: 4th week

  3. Visual analog scale

    A visual analog scale will be used to evaluate the patients' current pain severity. This scale is one of the frequently preferred scales to evaluate the pain intensity of patients during rest, activity and night. The scale has a 10 cm long line where the patient can mark the intensity of pain. The patient will be asked to indicate the degree of pain intensity between no pain (left part) and unbearable pain (right part) of the line.

    Time frame: 6th week

  4. Edema

    Edema measurement will be done using a thin measuring tape, measuring in figure-eight increments, and recorded in centimeters.

    Time frame: Baseline

  5. Edema

    Edema measurement will be done using a thin measuring tape, measuring in figure-eight increments, and recorded in centimeters.

    Time frame: 4th week

  6. Edema

    Edema measurement will be done using a thin measuring tape, measuring in figure-eight increments, and recorded in centimeters.

    Time frame: 6th week

  7. Grip Strength

    The Jamar hand dynamometer, recommended by the American Association of Hand Therapists (AETD) and considered the gold standard due to its high validity and reliability in numerous studies, will be used to measure hand grip strength. Hand grip strength will be measured in the standard position recommended by the AETD: seated, with shoulder adduction and neutral rotation, elbow 90 degrees flexion, forearm mid-rotation and supported, and wrist in neutral position. According to the test procedure, three consecutive measurements of hand grip strength will be taken, and the averages will be recorded in kilograms.

    Time frame: Baseline

  8. Grip Strength

    The Jamar hand dynamometer, recommended by the American Association of Hand Therapists (AETD) and considered the gold standard due to its high validity and reliability in numerous studies, will be used to measure hand grip strength. Hand grip strength will be measured in the standard position recommended by the AETD: seated, with shoulder adduction and neutral rotation, elbow 90 degrees flexion, forearm mid-rotation and supported, and wrist in neutral position. According to the test procedure, three consecutive measurements of hand grip strength will be taken, and the averages will be recorded in kilograms.

    Time frame: 4th week

  9. Grip Strength

    The Jamar hand dynamometer, recommended by the American Association of Hand Therapists (AETD) and considered the gold standard due to its high validity and reliability in numerous studies, will be used to measure hand grip strength. Hand grip strength will be measured in the standard position recommended by the AETD: seated, with shoulder adduction and neutral rotation, elbow 90 degrees flexion, forearm mid-rotation and supported, and wrist in neutral position. According to the test procedure, three consecutive measurements of hand grip strength will be taken, and the averages will be recorded in kilograms.

    Time frame: 6th week

  10. Pinch Strength

    Pinch strength measurement will be performed in the standard position recommended by AETD; sitting position, shoulder in adduction and neutral rotation, elbow 90 degrees flexion, forearm in mid-rotation and supported, wrist in neutral position. According to the test procedure, 3 consecutive measurements will be taken for pinch strength and the averages will be recorded in kg.

    Time frame: Baseline

  11. Pinch Strength

    Pinch strength measurement will be performed in the standard position recommended by AETD; sitting position, shoulder in adduction and neutral rotation, elbow 90 degrees flexion, forearm in mid-rotation and supported, wrist in neutral position. According to the test procedure, 3 consecutive measurements will be taken for pinch strength and the averages will be recorded in kg.

    Time frame: 4th week

  12. Pinch Strength

    Pinch strength measurement will be performed in the standard position recommended by AETD; sitting position, shoulder in adduction and neutral rotation, elbow 90 degrees flexion, forearm in mid-rotation and supported, wrist in neutral position. According to the test procedure, 3 consecutive measurements will be taken for pinch strength and the averages will be recorded in kg.

    Time frame: 6th week

Secondary outcomes

  1. Patient-Reported Wrist Assessment Questionnaire

    The Patient-Reported Wrist Assessment Questionnaire (PRWE) will be used to assess patients' activities of daily living, pain levels, and functional impairment (disability). On the pain subscale of the PRWE, the patient can score a maximum of 50 points, and on the function subscale, a maximum of 50 points. The total PRWE score assesses both pain and functional impairment. Higher scores indicate more severe pain and more significant functional impairment/disability.

    Time frame: Baseline

  2. Patient-Reported Wrist Assessment Questionnaire

    The Patient-Reported Wrist Assessment Questionnaire (PRWE) will be used to assess patients' activities of daily living, pain levels, and functional impairment (disability). On the pain subscale of the PRWE, the patient can score a maximum of 50 points, and on the function subscale, a maximum of 50 points. The total PRWE score assesses both pain and functional impairment. Higher scores indicate more severe pain and more significant functional impairment/disability.

    Time frame: 4th week

  3. Patient-Reported Wrist Assessment Questionnaire

    The Patient-Reported Wrist Assessment Questionnaire (PRWE) will be used to assess patients' activities of daily living, pain levels, and functional impairment (disability). On the pain subscale of the PRWE, the patient can score a maximum of 50 points, and on the function subscale, a maximum of 50 points. The total PRWE score assesses both pain and functional impairment. Higher scores indicate more severe pain and more significant functional impairment/disability.

    Time frame: 6th week

07

Study locations

No study locations are listed for this record.

08

References and documents

Publications

  • Horoz L, Karacay BC, Ceylan I, Cakmak MF. Is home-based real-time video conferencing telerehabilitation as effective as conventional face-to-face rehabilitation in patients with operated for distal radius fracture? A single-blind, randomized prospective study. Turk J Phys Med Rehabil. 2024 Apr 26;70(4):506-516. doi: 10.5606/tftrd.2024.13739. eCollection 2024 Dec. PubMed 40028408 ↗
  • Cigdem-Karacay B, Horoz L, Ceylan I, Alkan H. Effectiveness of instrument-assisted soft tissue mobilization in patients operated for distal radius fracture: A randomized controlled blinded clinical study. J Hand Ther. 2026 Jan-Mar;39(1):236-244. doi: 10.1016/j.jht.2025.05.009. Epub 2025 Jul 5. PubMed 40619299 ↗
  • Cigdem-Karacay B, Horoz L, Ceylan I, Alkan H. The effectiveness of dry heat treatment (fluidotherapy) in patients with distal radius fracture followed conservatively: a single-blinded, randomized controlled clinical study. Rev Assoc Med Bras (1992). 2025 Dec 8;71(11):e20250806. doi: 10.1590/1806-9282.20250806. eCollection 2025. PubMed 41370488 ↗

Individual participant data

Plan to share: No

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 17, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07756619
Responsible party
Basak Cigdem Karacay (Principal Investigator, Kirsehir Ahi Evran Universitesi) — Principal investigator
First posted
Aug 10, 2026
Start date
Sep 1, 2026 (estimated)
Primary completion
May 1, 2027 (estimated)
Completion
Jun 1, 2027 (estimated)
Last update
Aug 17, 2026

Study contacts

Basak Cigdem Karacay, Assoc Prof
Contact
basak.cigdemkaracay@ahievran.edu.tr
+90-386-280-4101
Basak Cigdem Karacay, Assoc Prof
principal investigator · Kirsehir Ahi Evran Universitesi

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion