An interventional study of Mulligan mobilization and Conventional Physiotherapy in Rotator Cuff Tears and Physical Disability, sponsored by Kirsehir Ahi Evran Universitesi. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-06-08.
Sponsored by Kirsehir Ahi Evran Universitesi · Not applicable, Interventional, and Treatment
Among 85 studies in Rotator Cuff Injuries with a site in Turkey — 19 open to participants now, 23 under way, none of them phase 3. Rotator Cuff Injuries · Turkey.
Among the 85 studies in Rotator Cuff Injuries with a site in Turkey, this one is the 8th largest by planned enrollment of the 63 interventional ones, is one of 12 that started in 2025, is one of 63 with no phase, reaches primary completion later than 11 of the 22 other live ones, and was the 73rd registered.
631 studies on the registry are indexed under Rotator Cuff Injuries; 156 are open to participants now.
This study's planned enrollment of 75 is above the median of 60 across 456 interventional studies indexed under Rotator Cuff Injuries.
Browse Rotator Cuff Injuries studies →19 of the 85 studies in Rotator Cuff Injuries with a site in Turkey are open now, in 1 country. Each count lists the studies.
Of the 100 Rotator Cuff Injuries studies recruiting now, 40 (40%) set no upper age limit and 41 (41%) stop at 75 or younger; 9 take children under 18; 10 take healthy volunteers.
This study: 18 Years to 65 Years · all sexes · no healthy volunteers.
The full table on the hub →85 studies; the count open now beside each. This study's row is marked.
First in 2016; this study’s year is marked. 12 started in 2025.
Median enrollment 44 across the 63 interventional studies, 50 across the 22 observational. Of the 57 that completed or were terminated, 1 (2%) have results posted.
None of the 85 has an industry lead sponsor. The 10 most frequent:
Kirsehir Ahi Evran Universitesi is the lead sponsor of 138 studies on the registry; 52 are open to participants now.
Kirsehir Ahi Evran Universitesi has 3 studies filed under Rotator Cuff Injuries — fewer than ten, so there is no comparison to draw.
5 of the studies in Rotator Cuff Injuries with a site in Turkey that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07587931Firat UniversityConcentric vs Eccentric Full Can Exercise in Partial Rotator Cuff Tears | 2026-11-20 |
| NCT07377292Ahi Evran University Education and Research HospitalEffectiveness of Core Stabilization Exercises in Rotator Cuff Injuries | 2026-12-25 |
| NCT07853950Ataturk UniversityFibrin Clot Augmentation in Arthroscopic Rotator Cuff Repair | 2027-02-28 |
| NCT07428070Istanbul Nisantasi UniversityContextually Enhanced Exercise Programs for Rotator Cuff-Related Shoulder Pain | 2027-05-06 |
| NCT07661680Fatih Sultan Mehmet Training and Research HospitalPerianchor Cyst Formation, Tendon Healing, and Clinical Outcomes Following Arthroscopic Rotator Cuff Repair | 2027-06-01 |
Among the 85 studies in Rotator Cuff Injuries with a site in Turkey, from their registry updates:
This randomized controlled trial aims to investigate the effects of Mobilization with Movement (MWM) on pain and functional status in individuals with rotator cuff lesions. Rotator cuff pathology is a common cause of shoulder pain and functional limitation, and impairments in proprioception may further compromise shoulder motor control and recovery.
Eligible participants with rotator cuff lesions will be randomly allocated into three groups: (1) Mobilization with Movement (MWM), (2) conventional physiotherapy, and (3) control group. All participants will be evaluated before and after the intervention period. Outcome measures will include shoulder-related functional disability assessed by the QuickDASH questionnaire, pain intensity, and shoulder joint position sense evaluated using an active repositioning test with a laser pointer during shoulder flexion.
The study is designed to determine whether MWM provides additional benefits over conventional treatment or task oriented training intervention in improving pain, function, and proprioceptive accuracy. The findings are expected to contribute to evidence-based conservative rehabilitation strategies for patients with rotator cuff lesions.
Rotator cuff lesions are among the most common causes of shoulder pain and functional limitation, particularly in middle-aged and older adults. Due to the wide range of motion and complex biomechanics of the glenohumeral joint, integrity of the rotator cuff muscles is essential for dynamic stability, coordinated movement, and precise joint positioning. Pathological changes in the rotator cuff may lead not only to pain and reduced functional capacity but also to impairments in proprioception, which can negatively affect motor control and increase the risk of recurrent injury.
Conservative management is widely recommended as the first-line treatment for rotator cuff lesions and typically includes therapeutic exercises, physical agents, and manual therapy techniques. Mobilization with Movement (MWM), developed within the Mulligan concept, is a manual therapy approach that combines sustained accessory joint mobilization with active, pain-free physiological movement. MWM is proposed to improve joint mechanics, reduce pain, and enhance neuromuscular and proprioceptive input. While previous studies have demonstrated the effectiveness of MWM in reducing pain and improving function in various musculoskeletal conditions, evidence regarding its effects on shoulder proprioception, particularly joint position sense, in individuals with rotator cuff lesions remains limited.
This randomized controlled trial is designed to evaluate the effects of MWM on pain, functional outcomes, and joint position sense in patients with rotator cuff lesions. Eligible participants diagnosed with rotator cuff pathology will be randomly assigned to one of three groups: (1) Mobilization with Movement (MWM) group, (2) conventional physiotherapy group, or (3) task oriented training group. Randomization will be performed after baseline assessment to ensure allocation concealment.
All participants will undergo standardized assessments at baseline (pre-intervention) and after completion of the intervention period (post-intervention). Functional status of the upper extremity will be evaluated using the Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) questionnaire. Pain intensity will be assessed using validated self-report measures. Shoulder proprioception will be assessed through a joint position sense test using an active repositioning method during shoulder flexion with a laser pointer system, recording the deviation from a predefined target point in centimeters.
The MWM group will receive manual therapy interventions based on Mulligan principles, applied by a trained physiotherapist, in addition to standard care. The conventional physiotherapy group will receive commonly used rehabilitation interventions excluding MWM techniques. The control group will not receive therapeutic intervention during the study period. All procedures will be conducted in accordance with the Declaration of Helsinki, and written informed consent will be obtained from all participants prior to enrollment.
The primary objective of this study is to determine whether MWM leads to superior improvements in pain, functional ability, and joint position sense compared with conventional physiotherapy and no intervention. Secondary objectives include evaluating the magnitude of treatment effects and exploring the relationship between changes in proprioception and functional outcomes. The results of this trial are expected to provide clinically relevant evidence regarding the role of Mobilization with Movement in conservative rehabilitation protocols for individuals with rotator cuff lesions.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will receive a conventional physiotherapy program commonly used in the conservative management of rotator cuff lesions. The program will include therapeutic exercises, stretching, and physical therapy modalities aimed at reducing pain and improving shoulder function. Mobilization with Movement or other Mulligan-based manual therapy techniques will not be applied in this group.
Other: Conventional Physiotherapy
Participants allocated to this arm will receive Mobilization with Movement interventions based on the Mulligan concept. The technique will involve the application of sustained accessory glenohumeral joint mobilization combined with active, pain-free shoulder movements. Interventions will be administered by a trained physiotherapist according to a standardized protocol. This group may also receive basic conventional physiotherapy components excluding other manual mobilization techniques.
Other: Mulligan mobilization
Participants allocated to this arm will receive a task-oriented training program delivered through virtual reality (VR)-based rehabilitation applications. The intervention will consist of goal-directed and functional upper extremity activities designed to simulate daily living tasks and promote active shoulder use. Training tasks will target reaching, grasping, object manipulation, and multidirectional arm movements requiring coordination, accuracy, and motor control.
Participants assigned to the Mobilization with Movement (MWM) group will receive manual therapy based on the Mulligan concept. The intervention will consist of the application of sustained, pain-free accessory mobilization to the glenohumeral joint combined with active physiological shoulder movements, primarily in shoulder flexion and abduction. The direction and grade of mobilization will be individually determined according to the patient's symptoms and movement restrictions, ensuring that all movements are performed within a pain-free range. MWM interventions will be administered by a trained physiotherapist following a standardized treatment protocol. Each treatment session will last approximately 20-30 minutes and will be applied multiple times per week throughout the intervention period. The primary goal of the intervention is to improve joint mechanics, reduce pain, and enhance proprioceptive input by facilitating normal, pain-free movement patterns.
Participants allocated to the conventional physiotherapy group will receive a standard rehabilitation program commonly used for rotator cuff lesions. The intervention will include therapeutic exercises targeting shoulder range of motion, strengthening of the rotator cuff and scapular stabilizing muscles, and stretching exercises for periarticular soft tissues. Physical therapy modalities such as heat or ultrasound may be applied as needed for pain management. This intervention will be delivered by a physiotherapist according to established clinical guidelines. Mobilization with Movement or other Mulligan-based manual therapy techniques will not be included in this group.
Quick Disabilities of the Arm, Shoulder and Hand questionnaire.
Upper Extremity Functional Disability, Higher scores better outcomes
Time frame: Baseline (pre-intervention) and at the end of the 8-week intervention period.
Visual Analog Scale
Pain Intensity-Lower score better outcomes
Time frame: Baseline (pre-intervention) and at the end of the 8-week intervention period.
Joint Position Sense Error (cm)
Shoulder Joint Position Sense-Proprioception was assessed by measuring joint position sense (JPS) using a laser.Lower score better outcomes
Time frame: Baseline (pre-intervention) and at the end of the 8-week intervention period.
Plan to share: No — Individual participant data collected in this study will not be made publicly available. Aggregate data and study results will be reported in scientific publications and presentations without including any identifiable participant information.
Started Aug 2025 (actual). Primary completion is estimated for Aug 2026, 12 months after the start.
Of 228 non-industry interventional studies with no phase under Rotator Cuff Injuries, half reached primary completion within 19 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 39. This study's planned 12 months is below that.
Counting every sponsor, half of 252 studies reached it within 23 months; a quarter within 11 and three quarters within 44.
How these figures are worked out, and which studies are left out of them.
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