An interventional study of Non-surgical Periodontal Treatment in Rheumatoid Arthritis (RA), Periodontitis and Gingivitis, sponsored by Ondokuz Mayıs University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-28.
Sponsored by Ondokuz Mayıs University · Not applicable, Interventional, and Treatment
This study evaluates the relationship between rheumatoid arthritis and periodontal health and examines the effects of nonsurgical periodontal treatment on clinical periodontal findings and gingival crevicular fluid biomarkers. Participants with and without rheumatoid arthritis were classified according to periodontal status as periodontally healthy, gingivitis, or periodontitis. Clinical periodontal measurements and gingival crevicular fluid levels of calprotectin (MRP-8/14) and interleukin-10 (IL-10) were evaluated at baseline, 1 month, and 3 months. Disease Activity Score-28 (DAS28) was also evaluated in participants with rheumatoid arthritis.
2,888 studies on the registry are indexed under Arthritis, Rheumatoid; 390 are open to participants now.
This study's enrollment of 54 is below the median of 94 across 1,984 interventional studies indexed under Arthritis, Rheumatoid.
Browse Arthritis, Rheumatoid studies →Ondokuz Mayıs University is the lead sponsor of 262 studies on the registry; 68 are open to participants now.
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Voluntary participation in the study. Aged 18 to 65 years. For participants in the rheumatoid arthritis groups, diagnosis of rheumatoid arthritis at least 1 year before enrollment.
For participants in the systemically healthy groups, absence of any systemic disease that may affect periodontal tissues.
No periodontal treatment within the previous 6 months. No local or systemic antibiotic use within the previous 3 months. Never having smoked or having stopped smoking at least 2 years before enrollment.
For participants in the periodontally healthy control groups, no history of periodontal disease and the presence of good oral hygiene.
Exclusion Criteria:
Unwillingness to participate in the study. Age younger than 18 years or older than 65 years. Presence of any systemic disease other than rheumatoid arthritis that may affect periodontal tissues.
Local or systemic antibiotic use within the previous 3 months. Periodontal treatment within the previous 6 months. Pregnancy or lactation. Use of medications that may affect gingival tissues, including calcium channel blockers, phenytoin, cyclosporine, or hormone replacement therapy.
Receiving biological treatment for rheumatoid arthritis, such as anti-tumor necrosis factor therapy.
Current smoking.
Participants with rheumatoid arthritis and periodontitis receive non-surgical periodontal treatment. This arm includes 9 participants.
Procedure: Non-surgical Periodontal Treatment
Systemically healthy participants with periodontitis receive non-surgical periodontal treatment. This arm includes 9 participants.
Procedure: Non-surgical Periodontal Treatment
Participants with rheumatoid arthritis and gingivitis receive non-surgical periodontal treatment. This arm includes 9 participants.
Procedure: Non-surgical Periodontal Treatment
Systemically healthy participants with gingivitis receive non-surgical periodontal treatment. This arm includes 9 participants.
Procedure: Non-surgical Periodontal Treatment
Participants with rheumatoid arthritis and periodontal health receive no periodontal treatment and serve as a comparison group. This arm includes 9 participants.
Systemically and periodontally healthy participants receive no periodontal treatment and serve as a comparison group. This arm includes 9 participants.
The intervention consists of oral hygiene instructions, full-mouth scaling, and subgingival instrumentation and root planing where clinically indicated. It is administered to participants with periodontitis or gingivitis after baseline assessments. Periodontally healthy groups receive no periodontal treatment.
Also known as: NSPT
Change in Gingival Crevicular Fluid Calprotectin (MRP-8/14) Levels
Gingival crevicular fluid calprotectin (MRP-8/14) levels were measured using an enzyme-linked immunosorbent assay (ELISA). Changes in calprotectin levels were evaluated over time and compared according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Gingival Crevicular Fluid Interleukin-10 (IL-10) Levels
Gingival crevicular fluid interleukin-10 (IL-10) levels were measured using an enzyme-linked immunosorbent assay (ELISA). Changes in IL-10 levels were evaluated over time and compared according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Probing Pocket Depth
Probing pocket depth was measured in millimeters using a periodontal probe as the distance from the gingival margin to the base of the periodontal pocket. Changes were evaluated over time according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Clinical Attachment Level
Clinical attachment level was measured in millimeters using a periodontal probe as the distance from the cementoenamel junction to the base of the periodontal pocket. Changes were evaluated over time according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Bleeding on Probing
Bleeding on probing was recorded as present or absent following gentle periodontal probing and expressed as the percentage of sites with bleeding. Changes were evaluated over time according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Plaque Index
Plaque accumulation was assessed using the Plaque Index. Changes in plaque scores were evaluated over time according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Gingival Index
Gingival inflammation was assessed using the Gingival Index. Changes in gingival index scores were evaluated over time according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Gingival Crevicular Fluid Volume
Gingival crevicular fluid volume was measured using Periopaper strips and a calibrated Periotron 8000 device. Changes in gingival crevicular fluid volume were evaluated over time according to rheumatoid arthritis status and periodontal condition.
Time frame: Baseline, 1 month, and 3 months
Change in Disease Activity Score-28 (DAS28)
Disease activity was evaluated in participants with rheumatoid arthritis using the Disease Activity Score-28 (DAS28). Changes in DAS28 scores were assessed following nonsurgical periodontal treatment.
Time frame: Baseline and 3 months
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Ondokuz Mayıs University