An observational study in Polypharmacy (Individuals Treated With 4 or More Medications), sponsored by Ondokuz Mayıs University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 60 Years to 99 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by Ondokuz Mayıs University · Observational
This study aims to evaluate the effects of polypharmacy on balance, fall risk, cognitive status, vestibular function, and hearing among individuals living in nursing homes. The study investigates the relationship between polypharmacy and balance, fall risk, cognitive, vestibular, and hearing-related outcomes.
This study aims to investigate the effects of polypharmacy on balance, fall risk, cognitive status, vestibular function, and hearing in individuals living in nursing homes. The study will evaluate the potential relationships between polypharmacy and cognitive status, balance performance, fall risk, vestibular functions, and hearing outcomes. Participants will undergo detailed assessments (Standardized Mini-Mental State Examination, Berg Balance Scale, Tinetti Test, Timed Up and Go Test, Functional Reach Test, Cognitive Vestibular Function Scale, and pure tone audiometry); the findings will be compared with control group data and analyzed.
The study population consisted of individuals aged 60 years and older living in nursing homes in Samsun. Participants were divided into two groups according to medication use: a polypharmacy group and a control group. All participants were able to walk independently, communicate verbally, and complete the study assessments.
Exclusion Criteria:
Polypharmacy Group: Individuals living in nursing homes who use four or more medications.
Control Group: Individuals living in nursing homes who use fewer than four medications or no medications.
Standardized Mini-Mental State Examination
Description: Individuals' cognitive status was assessed using the Standardized Mini-Mental State Examination and compared between the polypharmacy group and the control group.
Time frame: Baseline
Cognitive-Vestibular Function Scale
Individuals' cognitive-vestibular functions were assessed using the Cognitive-Vestibular Function Scale and compared between the polypharmacy group and the control group.
Time frame: Baseline
6-Meter Walk Test
Description: Individuals' gait speed was assessed using the 6-Meter Walk Test and compared between the polypharmacy group and the control group.
Time frame: Baseline
Functional Reach Test
Description: Individuals' dynamic balance and functional reach performance were assessed using the Functional Reach Test and compared between the polypharmacy group and the control group.
Time frame: Baseline
Timed Up and Go Test
Description: Individuals' functional mobility and fall risk were assessed using the Timed Up and Go Test and compared between the polypharmacy group and the control group.
Time frame: Baseline
Tinetti Balance and Gait Test
Description: Individuals' balance and gait performance were assessed using the Tinetti Balance and Gait Test and compared between the polypharmacy group and the control group.
Time frame: Baseline
Berg Balance Scale
Description: Individuals' balance performance was assessed using the Berg Balance Scale and compared between the polypharmacy group and the control group.
Time frame: Baseline
Pure-Tone Audiometry Hearing Thresholds
Description: Hearing thresholds were assessed by pure-tone audiometry at 250, 500, 1000, 2000, and 4000 Hz in both ears and compared between the study and control groups.
Time frame: Baseline
Plan to share: No — Individual participant data will not be shared with other researchers. Only aggregate study results will be reported in the publication.
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Ondokuz Mayıs University