A Phase 3 interventional study of Hydrogen Peroxide 40% and Salicylic Acid 40% in Plantar Wart, sponsored by Assiut University. Not yet recruiting. Open to participants aged 12 Years and older. Per ClinicalTrials.gov, last updated 2026-09-22.
Sponsored by Assiut University · Phase 3, Interventional, and Treatment
This randomized controlled trial aims to compare the efficacy and safety of topical hydrogen peroxide 40 percent versus topical salicylic acid 40 percent in the treatment of plantar warts.
Plantar warts are common benign lesions caused by human papillomavirus on weight-bearing areas causing pain and functional impairment. This is a randomized parallel assignment study conducted at the Outpatient Dermatology Clinic Assiut University Hospital. Eligible patients with clinically diagnosed plantar warts will be randomized in 1 to 1 ratio to topical hydrogen peroxide 40 percent applied once weekly by physician or topical salicylic acid 40 percent self-applied once daily. Treatment duration 12 weeks with assessments every 2 weeks including measurement size photographs clearance status adverse effects compliance and satisfaction.
171 studies on the registry are indexed under Warts; 35 are open to participants now.
This study's planned enrollment of 70 is close to the median of 70 across 155 interventional studies indexed under Warts.
Browse Warts studies →Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Stabilized topical hydrogen peroxide 40 percent w/w applied directly onto wart surface using single-use wooden-tipped applicator avoiding surrounding skin once weekly by physician for 12 weeks or until complete clearance after soaking foot 5 to 10 minutes and gentle debridement
Drug: Hydrogen Peroxide 40%
Commercially available salicylic acid 40 percent w/w as paint or plaster self-applied once daily onto wart surface with protection of surrounding skin with petrolatum for 12 weeks after soaking and gentle paring
Drug: Salicylic Acid 40%
Topical hydrogen peroxide 40 percent w/w solution in opaque light-protected applicator bottle applied once weekly for up to 12 weeks
Topical salicylic acid 40 percent w/w preparation applied once daily for up to 12 weeks
Number of participants with complete clinical clearance
Number of participants with complete clinical clearance defined as complete disappearance of plantar wart and restoration of normal skin markings
Time frame: At 12 weeks
Time to complete clearance
Time in weeks from treatment start to complete clinical clearance
Time frame: Up to 12 weeks
Change in wart surface area
Change in wart surface area in square millimeters measured in two perpendicular diameters using digital caliper from baseline
Time frame: From baseline to 12 weeks
Treatment-related pain score
Pain score assessed using 0 to 10 Visual Analogue Scale with 0 indicating no pain and 10 indicating worst pain with higher scores indicating worse pain
Time frame: Up to 12 weeks
Number of participants with local adverse effects
Number of participants who develop local adverse effects including blistering hyperpigmentation scarring or secondary infection
Time frame: Up to 12 weeks
Patient satisfaction score
Patient satisfaction assessed using 0 to 10 satisfaction scale with higher scores indicating greater satisfaction
Time frame: At 12 weeks
Number of participants with recurrence
Number of participants with recurrence of plantar warts after initial complete clearance
Time frame: Up to 12 weeks
No study locations are listed for this record.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Hydrogen Peroxide