An interventional study of Liquid Nitrogen Cryotherapy and Carbon Dioxide (CO₂) Laser Therapy in Palmoplantar Warts, sponsored by Bkahtawar Amin Medical and Dental College Multan. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Bkahtawar Amin Medical and Dental College Multan · Not applicable, Interventional, and Treatment
This randomized clinical trial will compare the effectiveness of liquid nitrogen cryotherapy and carbon dioxide (CO₂) laser therapy for treating palmoplantar warts, which are human papillomavirus-related skin growths occurring on the palms and soles.
The main question the study aims to answer is:
- Does CO₂ laser therapy achieve complete wart clearance more frequently than liquid nitrogen cryotherapy after 12 weeks of treatment?
The study will include 88 adults aged 18-50 years with palmoplantar warts. Participants will be randomly assigned to one of two treatment groups:
Participants will be assessed at week 12 after treatment initiation by a consultant dermatologist who will not know which treatment they received. Treatment response will be classified as complete clearance (no remaining warts), partial response (fewer warts than at baseline), or no response (the same or an increased number of warts). The researchers will compare the proportion of participants achieving complete wart clearance between the two groups. Adverse effects, including blistering, ulceration, and infection, will also be recorded during treatment.
171 studies on the registry are indexed under Warts; 35 are open to participants now.
This study's planned enrollment of 88 is above the median of 70 across 155 interventional studies indexed under Warts.
Browse Warts studies →Bkahtawar Amin Medical and Dental College Multan is the lead sponsor of 3 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
HIV
The human immunodeficiency virus, which weakens the immune system.
Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive liquid nitrogen cryotherapy at -196°C
Procedure: Liquid Nitrogen Cryotherapy
Participants will receive carbon dioxide (CO₂) laser therapy
Procedure: Carbon Dioxide (CO₂) Laser Therapy
Participants will be administered using two freeze-thaw cycles once weekly for a maximum of 8 weeks to treat palmoplantar warts.
Participants will be administered once weekly for a maximum of 8 weeks to treat palmoplantar warts.
Treatment Efficacy
Proportion of participants achieving complete clearance of palmoplantar warts, defined as the absence of any wart lesions at the 12-week assessment compared with baseline.
Time frame: From enrollment through the final assessment at 12-weeks (including 8 weeks of treatment)
Plan to share: No
No publications or documents are linked to this record.
Started Jun 2026 (actual). Primary completion is estimated for Dec 2026, 5 months after the start.
Of 28 interventional studies with no phase under Warts, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 31. This study's planned 5 months is below that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Bkahtawar Amin Medical and Dental College Multan