An interventional study of Salicylic acid solution (15-17%) and Tretinoin 0.05% cream in Plane Warts, sponsored by Combined Military Hospital, Pakistan. Not yet recruiting at 1 site in Pakistan. Open to participants aged 12 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-11-10.
Sponsored by Combined Military Hospital, Pakistan · Not applicable, Interventional, and Treatment
This randomized controlled trial aims to compare the effectiveness and safety of topical salicylic acid solution (15-17%) and tretinoin 0.05% cream in treating plane warts. A total of 200 patients aged 12-40 years will be recruited from the Dermatology Department of Combined Military Hospital (CMH), Abbottabad, and randomly divided into two treatment groups. Both treatments will be applied once daily at night for 12 weeks, with follow-up visits at weeks 4, 8, and 12. The primary outcome will be complete clearance of all warts at 12 weeks, while adverse effects such as redness, scaling, burning, itching, and pigmentation changes will also be assessed. The study aims to identify which treatment offers better efficacy and tolerability to support evidence-based treatment decisions for patients with plane warts.This randomized controlled trial aims to compare the effectiveness and safety of topical salicylic acid solution (15-17%) and tretinoin 0.05% cream in treating plane warts. A total of 200 patients aged 12-40 years will be recruited from the Dermatology Department of Combined Military Hospital (CMH), Abbottabad, and randomly divided into two treatment groups. Both treatments will be applied once daily at night for 12 weeks, with follow-up visits at weeks 4, 8, and 12. The primary outcome will be complete clearance of all warts at 12 weeks, while adverse effects such as redness, scaling, burning, itching, and pigmentation changes will also be assessed. The study aims to identify which treatment offers better efficacy and tolerability to support evidence-based treatment decisions for patients with plane warts
171 studies on the registry are indexed under Warts; 35 are open to participants now.
This study's planned enrollment of 200 is above the median of 70 across 155 interventional studies indexed under Warts.
Browse Warts studies →Combined Military Hospital, Pakistan is the lead sponsor of 15 studies on the registry; 4 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Group A (salicylic acid): Salicylic acid 15-17% solution will be provided to the patients and advised to apply the solution only once daily, especially at night time to the infected areas and let it remain there for 6-8 hours. Afterwards, it should be washed in the morning time.
Drug: Salicylic acid solution (15-17%)
Group B (tretinoin): Tretinoin 0.05% cream will be prescribed to the patients. They will be advised to apply the cream only once daily, especially at night time to the infected areas.
Drug: Tretinoin 0.05% cream
Group A (salicylic acid): Salicylic acid 15-17% solution
Group B (tretinoin): Tretinoin 0.05% cream
Proportion of patients achieving complete clearance of plane wart lesions at 12 weeks, defined as 100% clearance of all wart lesions, compared between the salicylic acid solution and tretinoin 0.05% cream treatment groups.
Time frame: 12 weeks
Change in Wart Lesion Count at 12 Weeks
Percentage reduction in the number of plane wart lesions from baseline to 12 weeks, categorized as: * Complete clearance: 100% reduction * Marked improvement: 75-99% reduction * Moderate improvement: 50-74% reduction * Mild improvement: 25-49% reduction * No response:
Time frame: 12 weeks
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Dec 2026; primary completion for May 2027, 5 months later.
Of 28 interventional studies with no phase under Warts, half reached primary completion within 10 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 31. This study's planned 5 months is below that.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Tretinoin
Combined Military Hospital, Pakistan