An interventional study of Individual ALDH2 Genotype Feedback and Standardized Alcohol Health Education in Alcohol Intolerance, Alcohol Drinking in College and Aldehyde Dehydrogenase-2 (ALDH2) Deficiency, sponsored by National Taiwan University Hospital. Completed at 1 site in Taiwan. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-03.
Sponsored by National Taiwan University Hospital · Not applicable, Interventional, and Prevention
Alcohol intolerance is common in East Asian populations and is strongly influenced by the rs671 variant in the ALDH2 gene. This study examined the associations of ALDH2 genotype with drinking behavior and alcohol-related reactions among Taiwanese university students. Participants with previous alcohol exposure underwent rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance and related health risks. Drinking behavior, knowledge, and attitudes were assessed before and one month after the intervention. The study also evaluated whether facial flushing and rapid heartbeat could help identify ALDH2 deficiency. Changes over the one-month period were evaluated overall and by genotype group.
38 studies on the registry are indexed under Alcohol Drinking in College; 8 are open to participants now.
This study's enrollment of 622 is above the median of 258 across 36 interventional studies indexed under Alcohol Drinking in College.
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Participants underwent ALDH2 rs671 genotyping and received their individual genotype results together with the same standardized health education materials about alcohol intolerance, alcohol-related reactions, and associated health risks. Drinking behavior, knowledge, and attitudes were assessed at baseline and one month after the intervention.
Behavioral: Individual ALDH2 Genotype Feedback · Behavioral: Standardized Alcohol Health Education
Participants underwent ALDH2 rs671 genotyping and received an individual report indicating their rs671 genotype (GG, GA, or AA) and corresponding ALDH2 metabolic status. No individualized health education was provided based on genotype.
All participants received the same standardized health education materials concerning alcohol metabolism, symptoms of alcohol intolerance, and health risks associated with alcohol use and ALDH2 deficiency. The educational content was not individualized according to genotype.
Change From Baseline in Drinking Frequency at One Month
Drinking frequency was assessed using a study-specific questionnaire with ordinal response categories reflecting the number of drinking occasions per month. The change score was calculated from the baseline and one-month responses according to the prespecified questionnaire coding.
Time frame: Baseline to one month after receipt of genotype feedback and health education
Change From Baseline in Alcohol Consumption per Drinking Occasion at One Month
Alcohol consumption per drinking occasion was assessed using ordinal categories of 1-2, 3-4, or 5 or more alcohol units. One alcohol unit was calculated as \[beverage volume (mL) × alcohol by volume (%)\]/1000. The change score was calculated from the baseline and one-month responses.
Time frame: Baseline to one month after receipt of genotype feedback and health education
Change From Baseline in Drinking Attitude Score at One Month
Attitudes toward drinking were assessed using six study-specific statements rated on a five-point Likert scale from strongly disagree to strongly agree. Items were coded according to the prespecified scoring method and summed to produce a total attitude score, with higher scores indicating healthier attitudes toward alcohol use.
Time frame: Baseline to one month after receipt of genotype feedback and health education
Change From Baseline in Alcohol Intolerance Knowledge Score at One Month
Knowledge was assessed using a study-specific questionnaire covering alcohol metabolism, symptoms of alcohol intolerance, related health risks, diagnosis, treatment, and prevalence. The total score was calculated from correct responses, with higher scores indicating greater knowledge.
Time frame: Baseline to one month after receipt of genotype feedback and health education
Plan to share: Yes — De-identified participant-level data underlying the findings reported in the published article may be shared, together with the relevant data dictionary. The data may include variables needed to reproduce the reported analyses, such as rs671 genotype, demographic characteristics, alcohol-related reactions, drinking behavior, knowledge, and attitude measures. Direct identifiers will not be shared.
Supporting information: Study protocol
Time frame: Data requests may be submitted after publication of the primary study results. Data will remain potentially available for as long as they are retained in accordance with institutional and ethical requirements.
Access criteria: Qualified researchers may submit a written request to the corresponding author describing the research purpose, analysis plan, requested variables, and data-security procedures. Access will require prior approval from the relevant institutional ethics committee, compliance with applicable informed-consent requirements, and execution of an appropriate data-use agreement. Data will not be shared without the required ethical approval and must not be redistributed or used in attempts to identify individual participants.
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This study is completed, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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