ClinicalTrials.gg
CompletedNCT07709247Updated Nov 3, 2026

Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients

An observational study in Osteoporosis, Dental Caries and Biomarkers, sponsored by Afyonkarahisar Health Sciences University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 45 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-03.

Sponsored by Afyonkarahisar Health Sciences University · Observational

Updated Nov 3, 2026Now CompletedFirst site in Turkey (Türkiye)+5 moreGo to Updates ↓
Study type
Observational
Model
Case-control
Time perspective
Cross-sectional
Enrollment
30
Ages
45 Years to 75 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 67 studies in Osteoporosis with a site in Turkey — 14 open to participants now, 17 under way, none of them phase 3. Osteoporosis · Turkey.

Enrollment
35th of 36
30 · median 107
Started
2026
with 9 others
Observational
36 of 67
10 open now
Registered
64th of 67
by date
Lead sponsor
2 of 67
Afyonkarahisar Health Sciences University

Among the 67 studies in Osteoporosis with a site in Turkey, this one is the 35th largest by enrollment of the 36 observational ones, is one of 10 that started in 2026, is one of 36 observational ones, and was the 64th registered.

By phase

67 studies; the count open now beside each. This study's row is marked.

Observationalthis study36 · 10 open
No phase26 · 3 open
Phase 34 · 0 open
Phase 41 · 1 open

By the year they started

First in 2001; this study’s year is marked. 10 started in 2026.

Size and results

Median enrollment 60 across the 31 interventional studies, 107 across the 36 observational. Of the 44 that completed or were terminated, 2 (5%) have results posted.

Was this useful?
Watch this landscapeDownload CSVWith an account: a weekly mail of what changed among 67 studies in Osteoporosis with a site in Turkey, or all of them as a file.
02

Study summary

This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured. Additionally, the dental caries status of participants will be evaluated. The aim of this study is to understand the relationship between osteoporosis and oral health. Only saliva samples will be collected from participants; no treatment or medication will be administered.

03

Conditions studied

  • Osteoporosis
  • Dental Caries
  • Biomarkers
  • Matrix Metalloproteinase 8
04

Who can participate

The criteria were revised on the registry on Nov 3, 2026. See what changed

Ages eligible
45 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients diagnosed with osteoporosis who applied to the outpatient clinic. Saliva samples and dental caries status will be evaluated. Participants will be selected according to inclusion and exclusion criteria.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Willing to give voluntary consent
  • For Group 1, having been diagnosed with osteoporosis
  • For Group 2, being systemically healthy and not having a diagnosis of -osteoporosis/osteopenia

Exclusion criteria

Exclusion Criteria:

  • Having a chronic inflammatory or disease
  • Using , anti-anxiety medications, antidepressants, or antiepileptic drugs
  • Having been diagnosed with any
  • Having any endocrine disease Having undergone periodontal treatment within the last 6 months
Terms in these criteria, in plain language(3)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Autoimmune disease

A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.

Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

05

Study design

Observational model
Case-control
Time perspective
Cross-sectional
Enrollment
30 participants (actual)
Patient registry
No

Groups and cohorts

  • Osteoporosis Group

    Patients diagnosed with osteoporosis. Saliva samples will be collected to measure cytokine levels and MMP-8.

  • Control Group

    Healthy individuals without osteoporosis. Saliva samples will be collected for comparison.

06

What researchers measure

Primary outcomes

  1. Salivary Cytokine Levels

    Measurement of cytokine levels in saliva samples collected from osteoporosis patients

    Time frame: day 1

07

Study locations

1 site
  • Afyonkarahisar Health Science University
    Afyonkarahisar, Turkey (Türkiye)
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedDate before it movedWhere the date was before it moved

Ran from Jul 2026 to primary completion in Jul 2026, 0 months.

Since we started tracking on Sep 25, 2026, the dates moved once, on Nov 3, 2026: primary completion Sep 2026 → Jul 2026 and completion Jul 2027 → Aug 2026.

Earlier changes are on the record history on ClinicalTrials.gov ↗

How these figures are worked out, and which studies are left out of them.

Registered
Jul 12, 2026
First posted
Jul 16, 2026
StartActual
Jul 10, 2026
Primary completionActual
Jul 20, 2026was Sep 2026
CompletionActual
Aug 10, 2026was Jul 2027
Last update
Nov 3, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Status
Not yet recruiting→Completed
changed Nov 3, 2026
Sites
1 site added — first site in Turkey (Türkiye)
Show site
  • Afyonkarahisar Health Science University · Afyonkarahisar, Turkey (Türkiye)
Nov 3, 2026
Primary completion
Sep 30, 2026→Jul 20, 2026 (actual)
Nov 3, 2026
Study completion
Jul 10, 2027→Aug 10, 2026 (actual)
Nov 3, 2026
Enrollment
50 (estimated)→30 (actual)
Nov 3, 2026
Eligibility
1 inclusion criterion edited, 2 added; 1 exclusion criterion edited, 3 added
What changed in the criteria
Inclusion criteria
  • AddedWilling to give voluntary consent
  • AddedFor Group 1, having been diagnosed with osteoporosis
  • EditedWilling to give voluntary consent For Group 1, having been diagnosed with osteoporosis For Group 2, being systemically healthy and not having a diagnosis of -osteoporosis/osteopenia
Exclusion criteria
  • AddedHaving a chronic inflammatory or autoimmune disease
  • EditedHaving a chronic inflammatory or autoimmune disease Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs Having been diagnosed with any malignancy Having any endocrine disease Having undergone periodontal treatment within the last 6 months
  • AddedHaving been diagnosed with any malignancy
  • AddedHaving any endocrine disease Having undergone periodontal treatment within the last 6 months
Nov 3, 2026
Show all 1 update
  1. Nov 3, 2026
    Not yet recruiting→Completed
    1 site added — first site in Turkey (Türkiye)
    Show site
    • Afyonkarahisar Health Science University · Afyonkarahisar, Turkey (Türkiye)
    Primary completion Sep 30, 2026→Jul 20, 2026 (now actual)
    Study completion Jul 10, 2027→Aug 10, 2026 (now actual)
    Enrollment 50 (estimated)→30 (actual)
    Eligibility 1 inclusion criterion edited, 2 added; 1 exclusion criterion edited, 3 added
    What changed in the criteria
    Inclusion criteria
    • AddedWilling to give voluntary consent
    • AddedFor Group 1, having been diagnosed with osteoporosis
    • EditedWilling to give voluntary consent For Group 1, having been diagnosed with osteoporosis For Group 2, being systemically healthy and not having a diagnosis of -osteoporosis/osteopenia
    Exclusion criteria
    • AddedHaving a chronic inflammatory or autoimmune disease
    • EditedHaving a chronic inflammatory or autoimmune disease Using glucocorticoids, anti-anxiety medications, antidepressants, or antiepileptic drugs Having been diagnosed with any malignancy Having any endocrine disease Having undergone periodontal treatment within the last 6 months
    • AddedHaving been diagnosed with any malignancy
    • AddedHaving any endocrine disease Having undergone periodontal treatment within the last 6 months
    + 1 other change: contact details

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07709247
Responsible party
Kübra Karaçam (Assistant Professor, Afyonkarahisar Health Sciences University) — Principal investigator
First posted
Jul 16, 2026
Start date
Jul 10, 2026
Primary completion
Jul 20, 2026
Completion
Aug 10, 2026
Last update
Nov 3, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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