An interventional study of SDF, ToothMate®, Egypt and SDF, Advantage Arrest USA in Dental Caries, sponsored by National Research Centre, Egypt. Active, not recruiting at 1 site in Egypt. Open to participants aged 4 Years to 8 Years. Per ClinicalTrials.gov, last updated 2026-07-28.
Sponsored by National Research Centre, Egypt · Not applicable, Interventional, and Treatment
this study aims to evaluate two different materials used to stop dental caries in children. both materials are available at the market. both materials leave black stain after application. we follow up the patients for 1 year to evaluate which one is more effective in stopping dental caries.
Before application of SDF, to protect the surrounding gingival tissues, cotton rolls will be used to minimize potential pigmentation. The lips and surrounded skin will also be protected using Vaseline. SDF in both groups will be applied directly to the affected tooth surface only, excess SDF will be removed with gauze, and finally the site will be isolated for up to three minutes.
All children will be recalled after 6 and 12 months for follow up.
1,109 studies on the registry are indexed under Dental Caries; 197 are open to participants now.
This study's enrollment of 134 is above the median of 60 across 916 interventional studies indexed under Dental Caries.
Browse Dental Caries studies →National Research Centre, Egypt is the lead sponsor of 49 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Egyptian manufactured SDF, 38% silver diamine fluoride is applied. Before application of tooth mate SDF, to protect the surrounding gingival tissues, cotton rolls will be used to minimize potential pigmentation. The lips and surrounded skin will also be protected using Vaseline. Tooth mate SDF will be applied by bond brush directly to the affected tooth surface only, excess SDF will be removed with gauze, and finally the site will be isolated for up to three minutes. All children will be recalled after 6 and 12 months for follow up
Other: SDF, ToothMate®, Egypt · Other: SDF, Advantage Arrest USA
USA manufactured SDF, 38% silver diamine fluoride. Before application of Advantage arrest SDF, to protect the surrounding gingival tissues, cotton rolls will be used to minimize potential pigmentation. The lips and surrounded skin will also be protected using Vaseline. Advantage arrest SDF will be applied by bond brush directly to the affected tooth surface only, excess SDF will be removed with gauze, and finally the site will be isolated for up to three minutes. All children will be recalled after 6 and 12 months for follow up
Other: SDF, ToothMate®, Egypt · Other: SDF, Advantage Arrest USA
38% silver diamine fluoride manufactured in Egypt
38% silver diamine fluoride , manufactured in USA
number of tooth with arrested caries in each group
Arrest of caries through: * tactile examination to assess hardness of treated lesions using gentle pressure with a probe, * color examination (yellow, brown or black)
Time frame: 12 months
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Plan to share: No
This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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National Research Centre, Egypt