An observational study in Cardiovascular Diseases, Coronary Artery Disease and Aging, sponsored by South Tees Hospitals NHS Foundation Trust. Terminated at 1 site in United Kingdom. Open to participants aged 40 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-07-09.
Sponsored by South Tees Hospitals NHS Foundation Trust · Observational
The investigators of this study have found that after a heart attack, some heart cells rapidly age (become senescent) and release proteins that make the heart disease worse.
The investigators of this study would like to check for these aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease.
The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help tell us who is at the highest risk of developing heart disease and how people recover from a heart attack.
The goal of this observational study is to compare the levels of aged-cell proteins in participants who have coronary artery bypass graft (CABG) surgery after a recent heart attack or to treat more stable heart disease.
The main questions it aims to answer are:
The investigators will do this by taking blood samples and a sample of normally discarded heart tissue from each group of participants. This might help inform who is at the highest risk of developing heart disease and how patients recover from a heart attack.
5,368 studies on the registry are indexed under Cardiovascular Diseases; 939 are open to participants now.
This study's enrollment of 22 is below the median of 506 across 1,572 observational studies indexed under Cardiovascular Diseases.
Browse Cardiovascular Diseases studies →South Tees Hospitals NHS Foundation Trust is the lead sponsor of 19 studies on the registry; 3 are open to participants now.
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The study population are male and female patients undergoing CABG surgery. There will be 70 patients split between two groups of 35 patients each.
Group I will be patients who are undergoing coronary artery bypass graft surgery for recent Non-ST segment elevation myocardial infarction (NSTEMI), and Group II will be patients undergoing CABG for stable coronary artery disease
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
LVEF (left ventricular ejection fraction)
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients who are undergoing CABG surgery for Non-ST segment elevation myocardial infarction (NSTEMI)
Patients who are undergoing CABG surgery for stable angina
Increase in senescent myocardial cells and senescence-associated secretory phenotype (SASP).
Blood samples taken to measure expression of a range of biomarkers.
Time frame: From baseline to 6 weeks.
Correlation of senescence and SASP with clinical outcomes
Measures include incidences of mortality, stroke, duration of inotrope and vasopressor administration and other markers of myocardial disease, including troponins.
Time frame: From baseline to 6 weeks
Progression of chronic cardiovascular disease
Progression of chronic cardiovascular disease will be determined using serum NT-proBNP at 6 weeks post surgery
Time frame: baseline to 6 weeks
Clinical outcomes post surgery
Clinical outcomes associated with poorer recovery from MI
Time frame: Baseline to 6 weeks
Plan to share: No
This study is terminated, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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South Tees Hospitals NHS Foundation Trust