An interventional study of Soleus pushup exercise in Hypothyroidism, Hypertension and Healthy Adult, sponsored by King Abdullah University Hospital. Completed at 1 site in Jordan. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-07.
Sponsored by King Abdullah University Hospital · Not applicable, Interventional, and Treatment
The study examines the immediate effect of soleus pushup exercise on cardiometabolic and hormonal functions among hypothyroid patients.
The primary characteristic of hypothyroidism is sluggish metabolism, which is usually associated with abnormal weight gain, lethargy, constipation, heavy menstrual bleeding, hair loss, cold intolerance, and bradycardia. Importantly, these symptoms have been linked to reduced glucose tolerance and insulin sensitivity though glucose turnover and plasma insulin concentration are elevated. These metabolic changes result in hyperlipidemia, hypercholesterolemia, and elevated insulin resistance, and circulatory low-density lipoprotein cholesterol and total triglyceride levels. Hormonal replacement therapy, the primary treatment for hypothyroidism, partially restores the thyroid function and tappers down the disease symptoms. However, the therapy is associated a plethora of side effects, thus alternative therapies are warranted.
The effect of exercise on thyroid function and metabolism among patients with hypothyroidism is still equivocal. The soleus pushup exercise, a localized exercise that stimulates mainly oxidative metabolism, has been shown to have promising, favorable changes in systemic metabolism. Therefore, the current study compares metabolic and hormonal responses to soleus pushup exercise in patients with hypothyroidism versus healthy controls.
Patients diagnosed with hypothyroidism are recruited to participate in the study. Cardiovascular and circulatory, metabolic, and hormonal measures are determined from blood samples obtained from the patients. Age- and gender-matched healthy individuals are recruited to serve as controls.
217 studies on the registry are indexed under Hypothyroidism; 50 are open to participants now.
This study's enrollment of 60 is below the median of 70 across 109 interventional studies indexed under Hypothyroidism.
Browse Hypothyroidism studies →King Abdullah University Hospital is the lead sponsor of 55 studies on the registry; 22 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Hypothyroid patients
Behavioral: Soleus pushup exercise
Health controls
Behavioral: Soleus pushup exercise
The participants are given the soleus push-up exercise
Total cholesterol
Total cholesterol will be measured in blood and reported in mg/dL.
Time frame: 3 hours
Triglycerides
Triglycerides will be measured in blood and reported in mg/dL.
Time frame: 3 hours
HDL-C
High-density lipoprotein cholesterol will be measured in blood and reported in mg/dL.
Time frame: 3 hours
LDL-C
Low-density lipoprotein cholesterol will be calculated using the lipid profile and reported in mg/dL.
Time frame: 3 hours
VLDL-C
Very-low-density lipoprotein cholesterol will be calculated from triglycerides and reported in mg/dL.
Time frame: 3 hours
Non-HDL cholesterol
Non-HDL cholesterol will be calculated as total cholesterol minus HDL-C and reported in mg/dL.
Time frame: 3 hours
Apolipoprotein A-I
Apolipoprotein A-I will be measured in blood and reported in mg/dL.
Time frame: 3 hours
Apolipoprotein B
Apolipoprotein B will be measured in blood and reported in mg/dL.
Time frame: 3 hours
Lipoprotein(a)
Lipoprotein(a) will be measured in blood and reported in mg/dL or nmol/L, depending on the laboratory assay.
Time frame: 3 hours
Fasting blood glucose
Fasting blood glucose will be measured in blood and reported in mg/dL.
Time frame: 3 hours
Random blood glucose
Random blood glucose will be measured in blood and reported in mg/dL.
Time frame: 3 hours
HbA1c
Glycated hemoglobin will be measured in blood and reported as a percentage.
Time frame: 3 hours
Insulin
Insulin will be measured in blood and reported in µIU/mL or mIU/L, depending on the laboratory assay.
Time frame: 3 hours
Glucagon
Glucagon will be measured in blood and reported in pg/mL.
Time frame: 3 hours
Catecholamines
Catecholamines will be measured in blood and reported in pg/mL.
Time frame: 3 hours
Thyroid-stimulating hormone
Thyroid-stimulating hormone will be measured in blood and reported in mIU/L or µIU/mL, depending on the laboratory assay.
Time frame: 3 hours
Triiodothyronine
Triiodothyronine will be measured in blood and reported in ng/dL.
Time frame: 3 hours
Thyroxine
Thyroxine will be measured in blood and reported in µg/dL.
Time frame: 3 hours
Brain-derived neurotrophic factor
Brain-derived neurotrophic factor will be measured in blood and reported in pg/mL or ng/mL, depending on the laboratory assay.
Time frame: 3 hours
Leptin
Leptin will be measured in blood and reported in ng/mL.
Time frame: 3 hours
Adiponectin
Adiponectin will be measured in blood and reported in µg/mL.
Time frame: 3 hours
Glucagon-like peptide
Glucagon-like peptide will be measured in blood and reported in pmol/L or pg/mL, depending on the laboratory assay.
Time frame: 3 hours
Heart rate
Heart rate will be measured using the standard auscultatory method and reported in beats per minute.
Time frame: 3 hours
Systolic blood pressure
Systolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.
Time frame: 3 hours
Diastolic blood pressure
Diastolic blood pressure will be measured using the standard auscultatory method and reported in mmHg.
Time frame: 3 hours
Pulse pressure
Pulse pressure will be calculated as systolic blood pressure minus diastolic blood pressure and reported in mmHg.
Time frame: 3 hours
Rate-pressure product
Rate-pressure product will be calculated as heart rate multiplied by systolic blood pressure and reported in bpm × mmHg.
Time frame: 3 hours
Mean arterial pressure
Mean arterial pressure will be calculated as diastolic blood pressure plus one-third of pulse pressure and reported in mmHg.
Time frame: 3 hours
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
King Abdullah University Hospital