An interventional study of Moderate-Intensity Continuous Training (MICT) and High-Intensity Interval Training (HIIT) in Multiple Sclerosis, High-intensity Interval Training and Gait, sponsored by Hacettepe University. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by Hacettepe University · Not applicable, Interventional, and Treatment
Among 23 studies in Multiple Sclerosis by Hacettepe University — 6 open to participants now, 6 under way, none of them phase 3. Multiple Sclerosis · Hacettepe University.
Among the 23 studies in Multiple Sclerosis by Hacettepe University, this one is the 5th largest by planned enrollment of the 15 interventional ones that give a count, is one of 5 that started in 2026, is one of 15 with no phase, and was the 20th registered.
3,267 studies on the registry are indexed under Multiple Sclerosis; 662 are open to participants now.
Browse Multiple Sclerosis studies →6 of the 23 studies in Multiple Sclerosis by Hacettepe University are open now, in 1 country. Recruiting first, the newest first:
Hacettepe University · Sites in Turkey
Ages 18–65
Hacettepe University · Sites in Turkey
Ages 18+
Hacettepe University · Sites in Turkey
Ages 10+ · Healthy volunteers
Hacettepe University · Sites in Turkey
Ages 18–70
Hacettepe University · Sites in Turkey
By country, each count listing its studies:
Of the 430 Multiple Sclerosis studies recruiting now, 163 (38%) set no upper age limit and 211 (49%) stop at 75 or younger; 40 take children under 18; 96 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
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23 studies; the count open now beside each. This study's row is marked.
First in 2015; this study’s year is marked. 5 started in 2026.
This study's planned enrollment of 40 is below the median of 50 across 2,203 interventional studies indexed under Multiple Sclerosis.
Median enrollment 34 across the 15 interventional studies, 56 across the 8 observational. Of the 13 that completed or were terminated, 0 (0%) have results posted.
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Hacettepe University is the lead sponsor of 1,009 studies on the registry; 214 are open to participants now.
4 of the studies in Multiple Sclerosis by Hacettepe University that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07137624Hacettepe UniversityMotor Imagery and Action Observation for Gait Function in MS | 2026-11 |
| NCT07151534Hacettepe UniversityBody Awareness, Trunk Stability, and Arm Function in MS | 2026-12-31 |
| NCT07786987Hacettepe UniversityCone Evasion Walk Test in Multiple Sclerosis | 2027-06-30 |
| NCT07899411Hacettepe UniversityEvaluation of the Effect of Mental Imagery Training Combined With Modified Constraint-Induced Movement Therapy in Individuals With Multiple Sclerosis | 2027-10 |
Add all 4 to your calendar (.ics) → With an account.
Among the 23 studies in Multiple Sclerosis by Hacettepe University, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study aims to comparatively investigate the effects of low-volume High-Intensity Interval Training (HIIT) versus Moderate-Intensity Continuous Training (MICT) on gait, balance, cognitive functions, and neurovascular biomarkers (BDNF, VEGF) in individuals with Multiple Sclerosis (MS). This randomized controlled trial will be conducted at Hacettepe University, Faculty of Physical Therapy and Rehabilitation.
Individuals with MS aged 18 and older, with an EDSS score of 0-4, no relapse in the past three months, and medically stable condition will be randomized into two groups using a sealed-envelope method. Group 1 will receive MICT on a cycle ergometer (twice weekly, 8 weeks); Group 2 will receive low-volume HIIT with the same frequency. Both groups will receive an individualized physiotherapy program after each aerobic session. Outcomes include gait (TUG, T25FW, DGI), balance (Mini-BESTest, mCTSIB), cognitive function (BICAMS: SDMT, CVLT-II, BVMT-R), exercise capacity (ISWT), and blood biomarkers (BDNF, VEGF) assessed via ELISA.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
MMSE and MoCA
Short tests of memory and thinking, each scored out of 30. Lower scores suggest more difficulty; criteria give a range, either to include people with memory problems or to leave them out.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cycle ergometer-based MICT, twice weekly for 8 weeks, starting at 60% of peak workload, progressing to 80%. Sessions include 5-min warm-up, 20-30 min exercise, 5-min cool-down, followed by 30-min individualized physiotherapy.
Behavioral: Moderate-Intensity Continuous Training (MICT)
HIIT on cycle ergometer, twice weekly for 8 weeks. Protocol: 5-min warm-up (40% peak workload), 10 × 1-min intervals at 90% peak workload with 1-min active recovery (60% peak workload) between each, followed by 5-min cool-down. Total session: \~20 min aerobic + 30-min individualized physiotherapy.
Behavioral: High-Intensity Interval Training (HIIT)
Cycle ergometer-based exercise, twice weekly for 8 weeks. Starting intensity at 60% of peak workload, progressing to 80%. Each session includes 5-min warm-up, 20-30 min continuous exercise, and 5-min cool-down, followed by 30-min individualized physiotherapy program.
Cycle ergometer-based exercise, twice weekly for 8 weeks. Each session includes 5-min warm-up (40% peak workload), 10 × 1-min intervals at 90% peak workload with 1-min active recovery (60% peak workload) between each interval, and 5-min cool-down. Total aerobic exercise duration: \~20 min, followed by 30-min individualized physiotherapy program.
Timed Up and Go Test (TUG)
Timed Up and Go Test (TUG). Participants are asked to rise from a standard chair, walk 3 meters, turn around, walk back, and sit down as fast as safely possible. Measured in seconds. Lower values indicate better functional mobility and balance.
Time frame: Baseline and 8 weeks
Timed 25-Foot Walk Test (T25FW)
Timed 25-Foot Walk Test (T25FW). Participants are instructed to walk 7.62 meters (25 feet) as quickly and safely as possible. Measured in seconds. Lower values indicate better walking speed.
Time frame: Baseline and 8 weeks
Dynamic Gait Index (DGI)
Dynamic Gait Index (DGI). Assesses the ability to maintain balance while walking under varied conditions across 8 tasks. Minimum score: 0, Maximum score: 24. Higher scores indicate better dynamic gait balance.
Time frame: Baseline and 8 weeks
Incremental Shuttle Walk Test (ISWT)
Incremental Shuttle Walk Test (ISWT). Participants walk between two cones placed 9 meters apart at increasing speeds guided by audio signals until they can no longer maintain the required pace. Measured in meters walked. Higher values indicate better functional exercise capacity.
Time frame: Baseline and 8 weeks
Mini Balance Evaluation Systems Test (Mini-BESTest)
Mini Balance Evaluation Systems Test (Mini BESTest). Assesses dynamic balance across 14 items in 4 subsections: anticipatory postural control, reactive postural control, sensory orientation, and dynamic gait. Minimum score: 0, Maximum score: 28. Higher scores indicate better balance performance.
Time frame: Baseline and 8 weeks
Modified CTSIB (mCTSIB) - Static Posturography
Modified Clinical Test of Sensory Interaction and Balance (mCTSIB). Assesses static postural stability under 4 conditions: eyes open/closed on firm and foam surfaces. Postural sway is measured in degrees per second. Lower values indicate better static balance.
Time frame: Baseline and 8 weeks
Serum BDNF levels (ELISA)
Time frame: Baseline and 8 weeks
Serum VEGF levels (ELISA)
Time frame: Baseline and 8 weeks
Symbol Digit Modalities Test (SDMT)
Part of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery. Assesses information processing speed in neurological conditions. Participants are asked to match symbols with corresponding digits within 90 seconds. Minimum score: 0, Maximum score: 110. Higher scores indicate better cognitive processing speed.
Time frame: Baseline and 8 weeks
California Verbal Learning Test-II (CVLT-II)
Part of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery. Assesses auditory and verbal memory. A list of 16 words across 4 categories is read aloud and recalled over 5 trials. Minimum score: 0, Maximum score: 80. Higher scores indicate better verbal learning and memory.
Time frame: Baseline and 8 weeks
Brief Visuospatial Memory Test-Revised (BVMT-R)
Part of the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) battery. Assesses visuospatial memory. Six geometric figures are presented and participants are asked to reproduce them from memory. Minimum score: 0, Maximum score: 36. Higher scores indicate better visuospatial memory.
Time frame: Baseline and 8 weeks
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Nov 2026; primary completion for Jun 2028, 19 months later.
Of 848 non-industry interventional studies with no phase under Multiple Sclerosis, half reached primary completion within 22 months of starting (the median), counting those still running; a quarter within 9 and three quarters within 43. This study's planned 19 months is below that.
Counting every sponsor, half of 870 studies reached it within 21 months; a quarter within 9 and three quarters within 43.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in May 2026. You cannot join it, but the record below documents what was studied.
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