An observational study in Hypotension, Anesthesia, General and Cholecystectomy, Laparoscopic, sponsored by University of Gaziantep. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-03.
Sponsored by University of Gaziantep · Observational
This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia. Researchers will measure the diameter of the internal jugular vein in patients before surgery and compare these measurements with the blood pressure changes during the first minutes of anesthesia. The goal is to determine if IJV-CI can be used as a reliable, non-invasive tool to identify patients at higher risk of developing anesthesia-induced hypotension.
Patients aged 18-65 scheduled for elective laparoscopic cholecystectomy under general anesthesia will be included in the study. Exclusion criteria are as follows: Obesity (BMI > 35 kg/m²), presence of Atrial Fibrillation or serious cardiac arrhythmia, history of neck surgery or any pathology preventing internal jugular vein measurement, advanced heart failure (Ejection Fraction \< 40%), severe valvular disease, peripheral vascular disease, emergency surgery, and refusal to participate in the study.
Upon arrival in the operating room, patients will be placed in a supine position. The Internal Jugular Vein (IJV) diameter will be monitored using a linear ultrasound probe during spontaneous breathing before anesthesia induction. The maximum and minimum diameters of the IJV during the respiratory cycle will be measured. The Internal Jugular Vein Collapsibility Index (IJV-CI) will be calculated using the following formula: [(IJV maximum diameter - IJV minimum diameter) / IJV maximum diameter] x 100.
Standard anesthesia induction will be performed. Non-invasive blood pressure and heart rate will be monitored and recorded at baseline (0 min), and at 1, 2, 3, 5, 7, 9, and 10 minutes following induction. Post-induction hypotension is defined as a decrease in mean arterial pressure (MAP) of more than 20% from the baseline value. The relationship between the pre-induction IJV-CI values and the development of hypotension during these specific time intervals will be statistically analyzed.
885 studies on the registry are indexed under Hypotension; 195 are open to participants now.
This study's planned enrollment of 42 is below the median of 90 across 265 observational studies indexed under Hypotension.
Browse Hypotension studies →University of Gaziantep is the lead sponsor of 105 studies on the registry; 28 are open to participants now.
Counted across the registry records on this site, refreshed daily.
The study population consists of adult patients aged 18-65 who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia. Participants will be selected from patients who meet the ASA I-III physical status criteria. The study focuses on evaluating pre-induction internal jugular vein characteristics using routine clinical monitoring data in a perioperative setting.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
LVEF (left ventricular ejection fraction)
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients who developed post-induction hypotension (MAP decrease \>20% or SBP \<90 mmHg). Pre-induction Internal Jugular Vein (IJV) ultrasonography was performed for statistical comparison.
Diagnostic Test: IJV-CI Measurement
Patients aged 18-65 scheduled for elective laparoscopic cholecystectomy who remained hemodynamically stable (no MAP decrease \>20% or SBP \<90 mmHg) after standard anesthesia induction. Pre-induction IJV measurement was performed to evaluate its predictive capacity."
Diagnostic Test: IJV-CI Measurement
Pre-induction Internal Jugular Vein (IJV) measurement will be performed using a linear ultrasound probe (5-12 MHz) while the patient is in the supine position. The IJV will be imaged in the transverse plane at the level of the cricoid cartilage. During spontaneous breathing, the maximum and minimum diameters of the vein will be recorded. The Collapsibility Index (IJV-CI) will be calculated using these measurements. This non-invasive assessment is performed immediately before the induction of general anesthesia to evaluate its predictive value for post-induction hypotension.
Also known as: IJV-CI, Internal Jugular Vein Collapsibility Index, IJV Ultrasonography
Internal Jugular Vein Collapsibility Index (IJV-CI)
Hypotension is defined as a decrease in Mean Arterial Pressure (MAP) of more than 20% from the baseline value. The predictive value of pre-induction IJV-CI for this occurrence will be assessed.Measurements will be recorded at 0, 1, 2, 3, 5, 7, 9, and 10 minutes following induction, but will stop if surgical incision occurs earlier than 10 minutes
Time frame: Baseline (pre-induction) and every minute up to 10 minutes following induction or until surgical in
Plan to share: No — Individual participant data will not be shared to protect patient confidentiality and privacy in accordance with local ethical committee guidelines and institutional data protection policies.
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Start is estimated for Aug 2026; primary completion for Jan 2027, 4 months later.
Of 146 non-industry observational studies under Hypotension, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 25. This study's planned 4 months is below that.
Counting every sponsor, half of 151 studies reached it within 11 months; a quarter within 5 and three quarters within 24.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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