An observational study in Heart Failure, Pulmonary Hypertension and Ventricular Dysfunction, Left, sponsored by University Hospital, Essen. Completed at 1 site in Germany. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-06.
Sponsored by University Hospital, Essen · Observational
This study evaluates how different non-invasive and invasive measurements reflect left ventricular filling pressure, an important indicator of cardiac function. Elevated filling pressure is associated with symptoms such as shortness of breath and plays a central role in the diagnosis and management of heart failure and pulmonary hypertension.
In clinical practice, filling pressure can be estimated using echocardiography or measured during cardiac catheterisation. However, the relationships between these measurements and their ability to accurately reflect true filling pressure are not fully understood.
This retrospective study includes patients who underwent cardiac catheterisation with invasive haemodynamic assessment and temporally related echocardiographic evaluation as part of routine clinical care. The aim is to improve understanding of how different measurements relate to each other and to identify which parameters best reflect elevated filling pressure.
The results are expected to support more accurate interpretation of haemodynamic measurements and improve clinical decision-making, particularly regarding the use of non-invasive versus invasive assessment.
6,331 studies on the registry are indexed under Heart Failure; 1,396 are open to participants now.
This study's enrollment of 623 is above the median of 200 across 1,983 observational studies indexed under Heart Failure.
Browse Heart Failure studies →University Hospital, Essen is the lead sponsor of 118 studies on the registry; 35 are open to participants now.
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Consecutive adult patients undergoing clinically indicated left- and right-heart catheterisation at the West German Heart and Vascular Centre Essen, University Hospital Essen, Germany, with available invasive haemodynamic measurements and echocardiographic assessment as part of routine clinical care.
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Exclusion Criteria:
Accuracy of non-invasive and invasive parameters for identifying elevated left ventricular filling pressure
Assessment of the ability of non-invasive and invasive surrogate parameters to identify elevated left ventricular filling pressure, with simultaneously obtained invasive left ventricular end-diastolic pressure serving as the reference standard
Time frame: At the time of cardiac catheterisation (baseline)
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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