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RecruitingNCT07429669Updated Feb 24, 2026

Comparative Analgesia and Respiratory Effects of Shoulder Blocks

An interventional study of Interscalene block and Anterior suprascapular block in Postoperative Pain and Arthroscopic Shoulder Surgery, sponsored by Atatürk Chest Diseases and Chest Surgery Training and Research Hospital. Recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-02-24.

Sponsored by Atatürk Chest Diseases and Chest Surgery Training and Research Hospital · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Feb 2026; still recruiting 8 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
120
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 16 studies in Pain, Postoperative by Atatürk Chest Diseases and Chest Surgery Training and Research Hospital — 6 open to participants now, 6 under way, none of them phase 3. Pain, Postoperative · Atatürk Chest Diseases and Chest Surgery Training and Research Hospital.

Planned enrollment
Largest of 12
120 · median 60
Started
2026
with 2 others
No phase
12 of 16
4 open now
Registered
14th of 16
by date

Among the 16 studies in Pain, Postoperative by Atatürk Chest Diseases and Chest Surgery Training and Research Hospital, this one has the largest planned enrollment of the 12 interventional ones, is one of 3 that started in 2026, is one of 12 with no phase, and was the 14th registered.

By phase

16 studies; the count open now beside each. This study's row is marked.

No phasethis study12 · 4 open
Observational4 · 2 open

By the year they started

First in 2021; this study’s year is marked. 3 started in 2026.

Size and results

Median enrollment 60 across the 12 interventional studies, 100 across the 4 observational. Of the 8 that completed or were terminated, 0 (0%) have results posted.

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02

Study summary

Interscalene block is widely accepted as the gold-standard regional analgesic technique for pain control after arthroscopic shoulder surgery. However, because this block is performed at the level of the brachial plexus roots, it may be associated with adverse effects such as phrenic nerve blockade and subsequent diaphragmatic dysfunction. These limitations have prompted the search for alternative regional anesthesia techniques that can provide effective postoperative analgesia while preserving respiratory function.

The anterior suprascapular block, which covers a broad dermatomal distribution of the shoulder region, has been shown in some studies to provide sufficient analgesia as a standalone technique. In addition, the pericapsular nerve group (PENG) block of the shoulder-applied around the anterior capsule and performed at a distance from critical neurovascular structures that may lead to serious complications-may represent another potential analgesic option following arthroscopic shoulder procedures.

Therefore, this study aims to evaluate alternative regional block techniques in comparison with the interscalene block and to contribute to the identification of an optimal analgesic strategy after arthroscopic shoulder surgery.

03

Conditions studied

  • Postoperative Pain
  • Arthroscopic Shoulder Surgery

Keywords

  • Interscalene block
  • Anterior suprascapular block
  • Pericapsular nerve group block
  • Shoulder Block
  • Arthroscopic shoulder surgery
  • Pain, acute
  • Pain, Postoperative
04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with ASA scores I-II-III
  • Patients scheduled for elective arthroscopic shoulder surgery
  • Patients who have been informed about the study and have given written consent will be included.

Exclusion criteria

Exclusion Criteria:

  • Those with a known allergy to local anesthetics
  • Those with an infection at the application site
  • Those with a severe coagulopathy disorder or anticoagulant use
  • Those with contralateral phrenic nerve palsy or a serious pulmonary diagnosis
  • Those with a history of chronic opioid use or neuropathic pain
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
120 participants (estimated)

Study arms

  • Active comparator
    Interscalene block

    In the preoperative period, 10 mL of 0.25% bupivacaine will be injected between C5 and C6 using an in-plane technique guided by a linear ultrasound (US) probe.

    Procedure: Interscalene block

  • Active comparator
    Anterior suprascapular block

    A linear ultrasound probe will be positioned in the supraclavicular fossa, parallel to the clavicle. The suprascapular nerve will be identified as a hyperechoic oval structure deep to the omohyoid muscle and posterior-lateral to the brachial plexus. 10 mL of local anesthetic will be injected under the omohyoid muscle, around the suprascapular nerve.

    Procedure: Anterior suprascapular block

  • Active comparator
    Pericapsular nerve group (PENG) block

    A linear ultrasound probe will be placed sagittally, near the axillary region, just below the coracoid process. The subscapularis muscle and its tendon will be visualized. The target area is the space between the deep fascia of the subscapularis muscle and the anterior surface of the shoulder joint capsule. The needle will pass the subscapularis muscle and be guided into the plane between the capsule and the muscle, where 20 mL of local anesthetic will be dispensed to block the articular branches innervating the capsule.

    Procedure: Pericapsular nerve group (PENG) block

Interventions

  • ProcedureInterscalene block

    Interscalene block will be performed, under US guidance, before the surgical operation, and when the patient is placed in the supine position.

  • ProcedureAnterior suprascapular block

    Anterior suprascapular block will be performed, under US guidance, before the surgical operation, and when the patient is placed in the supine position.

  • ProcedurePericapsular nerve group (PENG) block

    Pericapsular nerve group (PENG) block will be performed, under US guidance, before the surgical operation, and when the patient is placed in the supine position.

06

What researchers measure

Primary outcomes

  1. Pain scores

    Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 100 (worst pain) at the first postoperative hour.

    Time frame: First hour after the surgery

Secondary outcomes

  1. Pain scores

    Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 100 (worst pain). Pain assessment will be done at the 1st, 2nd, 6th, 12th, and 24th hours after surgery.

    Time frame: First 24 hours after surgery

  2. Forced vital capacity (FVC) (volume)

    Forced vital capacity (FVC) (volume) will be evaluated during the perioperative period. Measurements will be performed before block administration (baseline), at 30 minutes after the block, and at postoperative 1, 12, and 24 hours.

    Time frame: Perioperative period

  3. Forced expiratory flow in 1 s (FEV1) (volume)

    Forced expiratory flow in 1 s (FEV1) (volume) will be evaluated during the perioperative period. Measurements will be performed before block administration (baseline), at 30 minutes after the block, and at postoperative 1, 12, and 24 hours.

    Time frame: Perioperative period

  4. FEV1/FVC

    FEV1/FVC will be evaluated during the perioperative period. Measurements will be performed before block administration (baseline), at 30 minutes after the block, and at postoperative 1, 12, and 24 hours.

    Time frame: Perioperative period

07

Study locations

1 of 1 sites recruiting
08

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Started Feb 2026 (actual). Primary completion is estimated for Nov 2026, 8 months after the start.

Of 2,089 non-industry interventional studies with no phase under Pain, Postoperative, half reached primary completion within 11 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 23. This study's planned 8 months is below that.

Counting every sponsor, half of 2,102 studies reached it within 11 months; a quarter within 6 and three quarters within 23.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 13, 2026
First posted
Feb 24, 2026
StartActual
Feb 23, 2026
Primary completionEst.
Nov 10, 2026
CompletionEst.
Nov 30, 2026
Last update
Feb 24, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT07429669
Lead sponsor
Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Responsible party
Musa Zengin (Principal İnvestigator, Ankara Etlik City Hospital) — Principal investigator
First posted
Feb 24, 2026
Start date
Feb 23, 2026
Primary completion
Nov 10, 2026 (estimated)
Completion
Nov 30, 2026 (estimated)
Last update
Feb 24, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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