An observational study in Obsessive - Compulsive Disorder, Obsessive Compulsive Disorder (OCD) and Obsessive Compulsive Behavior, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-09.
Sponsored by Assiut University · Observational
This observational, cross-sectional case-control study evaluates obsessive-compulsive symptoms among adults with substance use disorder compared with a demographically similar control group without substance use disorder. Patients aged 18-50 years attending the addiction management inpatient and outpatient services at Assiut University Hospital, and healthy controls recruited from relatives, friends, and hospital staff, will complete structured clinical interviews, the Yale-Brown Obsessive-Compulsive Scale, and other standardized scales for psychiatric symptoms, cognition, and quality of life. The main objective is to estimate the prevalence and severity of obsessive-compulsive symptoms in substance use disorder and examine their associations with sociodemographic and clinical factors, addiction severity, and quality of life in the recovery stage.
Substance use disorders and obsessive-compulsive disorder are chronic, relapsing conditions that share underlying neurobiological mechanisms related to compulsivity and have substantial impact on functioning and quality of life. Clinical experience and prior research suggest that obsessive-compulsive symptoms may be under-recognized among individuals with substance use disorders, where they can worsen psychiatric comorbidity, complicate treatment, and impair recovery.
The current study will recruit 102 adults aged 18-50 years, including 51 patients with a diagnosed substance use disorder (single or polysubstance) from the inpatient and outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital, and 51 control participants without substance use disorder drawn from relatives, friends, and hospital workers. All participants must be in a non-intoxicated, non-withdrawal state and able to provide informed consent; individuals with severe psychiatric disorders (such as schizophrenia, bipolar disorder, major depressive disorder with severe features, or anorexia nervosa), severe medical illness, or marked cognitive impairment will be excluded.
Data collection will include a structured sociodemographic and clinical sheet, brief psychiatric interview, and administration of validated instruments such as the Yale-Brown Obsessive-Compulsive Scale, Obsessive Compulsive Drug Use Scale, Symptom Checklist-90-R, Montreal Cognitive Assessment, and Hamilton scales for anxiety and depression, along with urine analysis for substances. The primary objective is to assess the correlation between obsessive-compulsive symptoms in patients with substance use disorder and both symptom severity and quality of life, while secondary objectives address compulsive aspects of addiction, craving in patients with obsessive-compulsive symptoms, and potential implications for management strategies.
635 studies on the registry are indexed under Obsessive-Compulsive Disorder; 166 are open to participants now.
This study's planned enrollment of 102 is below the median of 133 across 86 observational studies indexed under Obsessive-Compulsive Disorder.
Browse Obsessive-Compulsive Disorder studies →Assiut University is the lead sponsor of 5,078 studies on the registry; 2,178 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Adults aged 18-50 years attending the inpatient and outpatient addiction management unit at the Neuropsychiatry Department, Assiut University Hospital, with a diagnosed substance use disorder, and a comparison group of relatives, friends, or hospital workers without substance use disorder. Participants of both sexes who provide informed consent will be assessed once during the recovery (non-intoxication, non-withdrawal) stage using structured clinical interviews, standardized scales for obsessive-compulsive symptoms, psychiatric comorbidity, cognition, and global psychopathology, as well as urine toxicology.
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--Adults aged 18-50 years.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Metastases
Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
COPD
Chronic obstructive pulmonary disease: long-term lung disease that makes it hard to breathe out, including emphysema and chronic bronchitis.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Adults aged 18-50 years with a diagnosed substance use disorder (single or polysubstance) attending the inpatient or outpatient addiction management unit at Assiut University Hospital, assessed for obsessive-compulsive symptoms, psychiatric comorbidities, cognition, and quality of life using standardized scales and urine toxicology.
Adults aged 18-50 years without substance use disorder, recruited from relatives, friends, or hospital workers, matched on sociodemographic characteristics where feasible, and assessed with the same clinical and psychometric battery to compare obsessive-compulsive symptoms and related outcomes with the patient group.
Severity of Obsessive-Compulsive Symptoms in Patients with Substance Use Disorder Measured by Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Total Score
Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score assessing severity of obsessive-compulsive symptoms in patients with substance use disorder. Scale ranges from 0 to 40 points, where higher scores indicate greater severity, assessed once at study enrollment during recovery stage defined as non-intoxication and non-withdrawal.
Time frame: Baseline (study enrollment during recovery stage defined as non-intoxication and non-withdrawal); single assessment
No study locations are listed for this record.
Start is estimated for Mar 2026; primary completion for Mar 2027, 12 months later.
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This study is not yet recruiting, as verified in Feb 2026. You cannot join it, but the record below documents what was studied.
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Obsessive-Compulsive Disorder →