An interventional study of Open high ligation varicocelectomy and Laparoscopic high ligation varicocelectomy in Varicocele, sponsored by Lahore General Hospital. Completed at 1 site in Pakistan. Open to male participants aged 20 Years to 60 Years. Per ClinicalTrials.gov, last updated 2026-01-20.
Sponsored by Lahore General Hospital · Not applicable, Interventional, and Treatment
Varicocele is a common condition in which veins around the testis become enlarged, and it may be associated with scrotal discomfort and reduced fertility. Surgical treatment aims to stop the backward flow of blood in these veins so that the testicular environment improves. This randomized controlled trial was conducted in the Department of Urology, PGMI, Lahore General Hospital, Lahore, over a six-month period.
Male patients aged 20 to 60 years with diagnosed varicocele and planned varicocelectomy under general anesthesia were enrolled after informed consent. Patients with recurrent varicocele, secondary varicocele, associated undescended testis, or a history of orchidopexy were excluded. Eligible participants were allocated into two groups using a lottery method. In Group A, high ligation was performed by the open method through a lower abdominal incision, with identification and ligation of the dilated testicular veins at a high level. In Group B, high ligation was performed laparoscopically using three small ports, with the testicular vein identified, clipped, and divided. Standard perioperative care was provided, including intravenous antibiotics and postoperative analgesia.
The study compared the two techniques in terms of mean operation time , length of hospital stay , and wound infection . The hypothesis was that a difference existed between open and laparoscopic high ligation varicocelectomy regarding operation time, hospital stay, and wound infection.
53 studies on the registry are indexed under Varicocele; 15 are open to participants now.
This study's enrollment of 100 is above the median of 72 across 36 interventional studies indexed under Varicocele.
Browse Varicocele studies →Lahore General Hospital is the lead sponsor of 32 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Open high ligation varicocelectomy
Procedure: Open high ligation varicocelectomy
Laparoscopic high ligation varicocelectomy
Procedure: Laparoscopic high ligation varicocelectomy
High ligation of the dilated testicular veins was performed by an open approach through a lower abdominal incision. The spermatic cord structures were approached extraperitoneally, the testicular vein was identified, separated from the artery after identification, and divided with ligatures. Wound closure was performed in layers with absorbable sutures and skin closure with silk sutures.
High ligation of the testicular vein was performed laparoscopically by inserting three ports. The testicular vessels were approached intraperitoneally, the testicular vein was identified, clipped, and divided. Wound closure was performed using absorbable suture material, with skin closure using silk sutures.
Mean operative time
Operative time was measured in minutes from skin incision until completion of skin closure (stitching).
Time frame: During the surgery
Length of hospital stay
Hospital stay was measured in days from the day of surgery until discharge from the hospital.
Time frame: Up to 30 days post-surgery
Wound infection rate
Wound infection was assessed at 10 days after surgery with confirmation by positive pus culture when discharge was present.
Time frame: 10 days after surgery
This study is completed, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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Lahore General Hospital