An interventional study of Microdebrider-Assisted Functional Endoscopic Sinus Surgery and Conventional Functional Endoscopic Sinus Surgery in Nasal Polyps, sponsored by Lahore General Hospital. Active, not recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-10-30.
Sponsored by Lahore General Hospital · Not applicable, Interventional, and Treatment
This study compared two surgical techniques for patients with nasal polyps affecting both sides of the nose and sinuses. Nasal polyps were soft swellings that caused symptoms such as nasal blockage, nasal discharge, and reduced sense of smell. The study assessed whether the amount of blood lost during surgery and the time required to complete surgery differed between microdebrider-assisted and conventional functional endoscopic sinus surgery.
The randomized controlled study was conducted in the Department of Ear, Nose and Throat at Lahore General Hospital, Lahore, over six months. It included 56 patients aged 18-70 years whose symptoms had persisted despite at least eight weeks of medical treatment. Patients were randomly assigned to two groups of 28 using sealed envelopes. Both groups underwent surgery under general anesthesia. In the microdebrider-assisted group, a powered instrument that cut and suctioned tissue simultaneously was used to remove the polyps. In the conventional group, standard surgical instruments, including forceps and curettes, were used.
Blood loss was measured in milliliters using the fluid collected through suction, after subtracting irrigation fluid, and the change in surgical sponge weights. Operative duration was recorded in minutes. These measurements were compared between the two groups. The study hypothesis was that microdebrider-assisted and conventional surgery differed in intraoperative blood loss and operative duration.
236 studies on the registry are indexed under Nasal Polyps; 68 are open to participants now.
This study's planned enrollment of 56 is close to the median of 60 across 181 interventional studies indexed under Nasal Polyps.
Browse Nasal Polyps studies →Lahore General Hospital is the lead sponsor of 32 studies on the registry; 4 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients underwent microdebrider-assisted functional endoscopic sinus surgery under general anesthesia following nasal decongestion with topical vasoconstrictors. Nasal polyps were removed using a microdebrider.
Procedure: Microdebrider-Assisted Functional Endoscopic Sinus Surgery
Patients underwent conventional functional endoscopic sinus surgery under general anesthesia following nasal decongestion with topical vasoconstrictors. Nasal polyps were removed using conventional surgical instruments.
Procedure: Conventional Functional Endoscopic Sinus Surgery
A powered microdebrider was used under endoscopic guidance to cut and suction polyp tissue simultaneously.
Polyp tissue was removed under endoscopic guidance using standard instruments, including forceps and curettes.
Mean Intraoperative Blood Loss
ntraoperative blood loss was measured in milliliters by combining the blood volume collected in the suction container, after subtracting irrigation fluid, with blood loss estimated from the difference between surgical sponge weights before and after use. Mean blood loss was compared between the microdebrider-assisted and conventional surgery groups.
Time frame: During the surgical procedure, with total blood loss assessed at the completion of surgery.
Mean Operative Duration
Operative duration was measured in minutes using a digital stopwatch, from the initial insertion of the endoscope until completion of surgery, including removal of all surgical instruments. Mean operative duration was compared between the microdebrider-assisted and conventional surgery groups.
Time frame: From initial insertion of the endoscope to completion of surgery during the same operative session.
Started Jun 2026 (actual). Primary completion is estimated for Nov 2026, 5 months after the start.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is active, not recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Lahore General Hospital