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CompletedNCT07237061RELAACUpdated Nov 19, 2025

Patient-preferred Aromatherapy Versus Placebo For Reducing Preoperative Anxiety In Patients Undergoing Eye Surgery

An interventional study of Aromatherapy and Placebo in Cataract, Surgery and Vitrectomy, sponsored by National University Hospital, Singapore. Completed at 1 site in Singapore. Open to participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2025-11-19.

Sponsored by National University Hospital, Singapore · Not applicable, Interventional, and Prevention

From the registry’s dates

  • Registered 2 years 3 months after the study started (first participant enrolled Mar 2023, registered Jun 2025).
Phase
Not applicable
Study type
Interventional
Enrollment
64
Allocation
Randomized
Ages
21 Years and older
Sex
All
01

Study summary

This study looks at whether aromatherapy (scent chosen by the patient), is better than routine care, at reducing preoperative anxiety before eye surgery.

02

Conditions studied

  • Cataract
  • Surgery
  • Vitrectomy
  • Aromatherapy
  • Preoperative Anxiety

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Keywords

  • randomized controlled trial
  • placebo controlled
  • double blinded
  • two arm
03

In context

Cataract

1,701 studies on the registry are indexed under Cataract; 230 are open to participants now.

This study's enrollment of 64 is below the median of 80 across 1,155 interventional studies indexed under Cataract.

Browse Cataract studies →

Lead sponsor

National University Hospital, Singapore is the lead sponsor of 444 studies on the registry; 96 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
21 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • mental capacity for informed consent
  • undergoing elective ambulatory eye surgery (including Phacoemulsification, Femtosecond laser-assisted cataract surgery (FLACS), Extracapsular cataract extraction (ECCE) and vitrectomy).
  • surgery only under Monitored Anaesthesia Care (MAC)3
  • surgical duration less than 45 minutes

Exclusion criteria

Exclusion Criteria:

  • anosmia
  • allergy to aromatherapy oil
  • asthma
  • allergic rhinitis
  • psychiatric disease
  • altered mental state
  • lack of mental capacity
  • active infection
  • pregnancy
  • patient or surgeon refused participation
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Care provider)
Enrollment
64 participants (actual)

Study arms

  • Placebo comparator
    placebo

    Patients were asked to choose amongst 4 different aromatherapy scents. The study administrator then stuck an adhesive patch without any aromatherapy oil on it, to the patient's facemask. This was worn throughout the perioperative experience from the ambulatory ward to the operating theatre and post anaesthesia care unit (PACU).

    Other: Placebo

  • Experimental
    intervention

    Patients were asked to choose amongst 4 different aromatherapy scents. The study administrator then stuck an adhesive patch with 1 drop of their chosen aromatherapy oil on it, to the patient's facemask. This was worn throughout the perioperative experience from the ambulatory ward to the operating theatre and post anaesthesia care unit (PACU).

    Other: Aromatherapy

Interventions

  • OtherAromatherapy

    patients chose their preferred aromatherapy scent to be used for at least 30 minutes

    Also known as: lavender, geranium, lemongrass, sandalwood

  • OtherPlacebo

    odorless dry absorbent adhesive patch

06

What researchers measure

Primary outcomes

  1. change in VAS scores for preoperative anxiety

    preoperative anxiety was ranked by the patient on a scale of 0-100 on a visual acuity scale (VAS) measuring 100mm, in the preoperative ambulatory ward, before and after the intervention/placebo was applied for at least 30 minutes. The change in the VAS score at these 2 timepoints was the primary outcome

    Time frame: 30-60 minutes

07

Study locations

1 site
  • National University Hospital Singapore
    Singapore, Singapore
08

References and documents

Individual participant data

Plan to share: No — local Patient Data Protection Act

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 19, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07237061
Lead sponsor
National University Hospital, Singapore
Responsible party
Sponsor
First posted
Nov 19, 2025
Start date
Mar 1, 2023
Primary completion
Mar 31, 2024
Completion
Dec 1, 2024
Last update
Nov 19, 2025

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.

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