An interventional study of Individually Neuronavigated accelerated intermittent theta burst stimulation with MagPro X100 in Anxiety and Fear-Related Disorders, sponsored by National University Hospital, Singapore. Not yet recruiting at 1 site in Singapore. Open to participants aged 21 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-09-03.
Sponsored by National University Hospital, Singapore · Not applicable, Interventional, and Treatment
Among 47 studies in Anxiety Disorders with a site in Singapore — 15 open to participants now, 20 under way, none of them phase 3. Anxiety Disorders · Singapore.
Among the 47 studies in Anxiety Disorders with a site in Singapore, this one is the 36th largest by planned enrollment of the 37 interventional ones that give a count, is one of 5 that started in 2026, is one of 35 with no phase, reaches primary completion later than 19 of the 19 other live ones, and was the 47th registered.
7,207 studies on the registry are indexed under Anxiety Disorders; 1,682 are open to participants now.
Browse Anxiety Disorders studies →15 of the 47 studies in Anxiety Disorders with a site in Singapore are open now. Recruiting first, the newest first:
Institute for Human Development and Potential (IHDP), Singapore · Sites in Singapore
Ages 21–75 · Healthy volunteers
National University of Singapore · Sites in Singapore
Ages 21+
Nanyang Technological University · Sites in Singapore
Ages 4–6 · Healthy volunteers
Singapore Management University · Sites in Singapore
Ages 18–30 · Healthy volunteers
KK Women's and Children's Hospital · Sites in Singapore
Ages 21–90
A study can be open while its sites in Singapore have not opened yet or have stopped. Only those recruiting at a site in Singapore →
Of the 944 Anxiety Disorders studies recruiting now, 417 (44%) set no upper age limit and 460 (49%) stop at 75 or younger; 233 take children under 18; 317 take healthy volunteers.
This study: 21 Years to 70 Years · all sexes · no healthy volunteers.
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47 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 5 started in 2026.
This study's planned enrollment of 24 is below the median of 80 across 6,062 interventional studies indexed under Anxiety Disorders.
Median enrollment 122 across the 37 interventional studies, 600 across the 10 observational. Of the 23 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
None of the 47 has an industry lead sponsor. The 10 most frequent:
National University Hospital, Singapore is the lead sponsor of 454 studies on the registry; 99 are open to participants now.
National University Hospital, Singapore has 2 studies filed under Anxiety Disorders — fewer than ten, so there is no comparison to draw.
4 of the studies in Anxiety Disorders with a site in Singapore that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07425951Nanyang Technological UniversityBuilding Cognitive Behavioural Skills With StoryBooks to Reduce Emotional Difficulties in Kindergarten Years | 2026-11-30 |
| NCT03408717KK Women's and Children's HospitalEvaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery | 2026-12-31 |
| NCT03415620KK Women's and Children's HospitalPerioperative Music Listening on Anxiety, Pain, Analgesia Use and Patient Satisfaction | 2026-12-31 |
| NCT03685422KK Women's and Children's HospitalPreoperative Virtual Reality to Reduce Pain on Gynaecologic Patients Undergoing Surgery | 2027-05-31 |
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Among the 47 studies in Anxiety Disorders with a site in Singapore, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This proposal seeks to carry out an open-label single arm study to examine the neurobehavioral changes induced by personalized, causal network mapping guided accelerated intermittent theta burst stimulation (aiTBS) in patients with treatment-resistant anxiety-related disorders.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants will receive an accelerated intermittent theta burst stimulation (iTBS) treatment delivered with a MagVenture MagPro X100 system (MagVenture A/S, Denmark) equipped with a butterfly shaped MagVenture Cool-B65 A/P coil. The treatment course is comprised of 6 treatment sessions daily for 5 consecutive workdays for a total of 30 sessions. Each iTBS session is approximately 10 minutes (depth corrected Resting Motor Threshold of 90%, 60 cycles of 10 bursts of three pulses at 50 Hz, repeated at 5 Hz; 2s on and 8s off; 1800 pulses per session; with a 50-minute interval between sessions). All iTBS sessions will be performed by staff trained and credentialed in TMS according to Singapore College of Psychiatrists guidelines.
Device: Individually Neuronavigated accelerated intermittent theta burst stimulation with MagPro X100
Magpro X100, Axilium Cobot, Localite Camera
Beck Anxiety Inventory (BAI)
The primary outcome will be the response rate as defined as ≥50% reduction from baseline BAI scores pre- and post-iTBS treatment. BAI is an ordinal self-report scale measuring physical and cognitive anxiety symptoms ranging from 0-63. Higher scores mean worse outcome.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Beck Depression Inventory (BDI)
Change in BDI scores pre- and post-iTBS treatment. BDI is an ordinal self-report scale measuring depressive symptoms ranging from 0-63. Higher scores mean worse outcome.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Penn State Worry Questionnaire (PSWQ)
Change in PSWQ scores pre- and post-iTBS treatment. PSWQ is an ordinal self-report scale measuring pathological worry ranging from 16-80. Scores depend on whether the item is worded positively or negatively.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Mini-Mood and Anxiety Symptom Questionnaire (Mini-MASQ)
Change in Mini-MASQ scores pre- and post-iTBS treatment. The Mini-MASQ is an orginal self-report scale measuring symptoms of anxiety and depression. Scores depend on whether the item is worded positively or negatively.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Hamilton Anxiety Rating Scale (HAM-A)
Change in HAM-A scores pre- and post-iTBS treatment. HAM-A is an ordinal clinician-rated scale measuring severity of psychic and somatic anxiety, ranging from 0-56. Higher scores mean a worse outcome.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Inventory of Depression and Anxiety Symptoms-II (IDAS-II)
Change in IDAS-II scores pre- and post-iTBS treatment. IDAS-II is an ordinal self-report scale measuring depression, anxiety, and bipolar symptoms ranging from 99-495. Higher scores mean worse outcome.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Sheehan Disability Scale (SDS)
Change in SDS scores pre- and post-iTBS treatment. SDS is an ordinal self-report scale measuring how symptoms affect functional imapirment across work/ school, social life, and family/ home responsibilities, ranging from 0-10 for each domain. Higher scores mean a worse outcome.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Correlation of changes in functional connectivity with changes in BAI scores
The investigators will perform additional exploratory post-hoc analyses by analysing brain imaging changes before and after TMS treatment.
Time frame: Baseline, immediately post-treatment, 1-month and 3-months post-intervention.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Sep 2026; primary completion for Dec 2029, 39 months later.
Of 3,841 non-industry interventional studies with no phase under Anxiety Disorders, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 28. This study's planned 39 months is above that.
Counting every sponsor, half of 3,943 studies reached it within 12 months; a quarter within 5 and three quarters within 28.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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National University Hospital, Singapore →