An interventional study of Levofloxacin and Moxifloxacin in Cataract and Postoperative Endophthalmitis, sponsored by Assiut University. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-30.
Sponsored by Assiut University · Not applicable, Interventional, and Prevention
This randomized study aims to compare the safety and efficacy of intracameral levofloxacin versus intracameral moxifloxacin administered at the end of phacoemulsification cataract surgery.
Postoperative endophthalmitis is a serious complication of cataract surgery. Intracameral antibiotics are used to reduce this risk.
This study will randomly assign patients undergoing elective phacoemulsification to receive either intracameral levofloxacin, intracameral moxifloxacin, or no intracameral antibiotic (control). Patients will be followed for visual outcomes, anterior chamber inflammation, and corneal endothelial safety.
Exclusion Criteria:
Patients will receive 0.1 mL of preservative-free levofloxacin 0.5% injected into the anterior chamber at the end of phacoemulsification.
Drug: Levofloxacin
Patients will receive 0.1 mL of preservative-free moxifloxacin 0.5% injected into the anterior chamber at the end of phacoemulsification.
Drug: Moxifloxacin
Patients will undergo standard phacoemulsification without any intracameral antibiotic injection.
0.1 mL of preservative-free levofloxacin 0.5% injected into the anterior chamber at the end of phacoemulsification.
0.1 mL of preservative-free moxifloxacin 0.5% injected into the anterior chamber at the end of phacoemulsification.
Incidence of postoperative endophthalmitis
Proportion of eyes that develop culture-proven or clinically diagnosed postoperative endophthalmitis.
Time frame: 1 month
Mean best-corrected visual acuity
Mean best-corrected visual acuity (BCVA) in logMAR
Time frame: 1 month
Mean endothelial cell density
Mean corneal endothelial cell density (cells/mm²) measured by specular microscopy.
Time frame: 1 month
Mean anterior chamber cell grade
Mean grade of anterior chamber cells according to Standardization of Uveitis Nomenclature (SUN) criteria.
Time frame: 1 week
Incidence of postoperative corneal edema
Proportion of eyes with clinically significant postoperative corneal edema.
Time frame: 1 week
Mean central corneal thickness
Mean central corneal thickness in micrometers.
Time frame: 1 month
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Assiut University