An observational study in Cancer and High-Risk Cancer, sponsored by Prisma Health-Upstate. Recruiting at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-02-17.
Sponsored by Prisma Health-Upstate · Observational
Prevent Cancer-Greenville was created to provide individuals with the opportunity to have their risk of developing cancer studied. Some individuals may be at a higher risk due to their personal lifestyle, family history and/or exposures. If subjects are found to be at high risk for developing a disease, they will be sent to a healthcare provider for further care.
Participants' personal history, lifestyle behaviors and blood, urine, and cheek swab specimens will be used to detect changes or trends that might put them at risk for developing cancer. Some individuals may be at an above average risk of cancer due to lifestyle, family background, personal genetic makeup, or environmental exposures. This will be determined by a process called risk stratification. Risk stratification involves looking at all health-related aspects of a person, determining their individualized risk through screening, and educating them on measures to reduce potential for disease. Participants will complete a yearly health assessment which includes measurements for nutrition, activity, individual risk factors and body composition, including weight height and a special scale which measures fluid and fat.
10,818 studies on the registry are indexed under Neoplasms; 2,324 are open to participants now.
This study's planned enrollment of 1,000 is above the median of 200 across 2,638 observational studies indexed under Neoplasms.
Browse Neoplasms studies →Prisma Health-Upstate is the lead sponsor of 76 studies on the registry; 7 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 10 (83%) have results posted.
Counted across the registry records on this site, refreshed daily.
Individuals 18 years or older
Inclusion Criteria:
Assess changes in nutrition by nutrition questionnaire
Nutrition will be assessed yearly by a questionnaire based on nutrition recommendations from the American Institute for Cancer Research and the U.S. Department of Health and Human Services.
Time frame: Yearly follow up for 10 years
Assess changes in physical activity by physical activity questionnaire
Physical activity will be assessed yearly a questionnaire based on physical activity recommendations from the U.S. Department of Health and Human Services.
Time frame: Yearly follow up for 10 years
Assess changes in smoking habits
Participants will be educated on healthy lifestyle habits and smoking habits will be assessed yearly.
Time frame: Yearly follow up for 10 years
Assess changes in alcohol use
Participants will be educated on healthy lifestyle habits and alcohol use will be assessed yearly.
Time frame: Yearly follow up for 10 years
Assess hereditary risk through family history review
Each participant's family history will be reviewed to make recommendations for screening or genetic testing based on National Comprehensive Cancer Network guidelines.
Time frame: Yearly follow up for 10 years
Assess lifetime breast cancer risk through the Tyrer-Cuzick version 8 breast risk evaluation tool
Participants' breast cancer risk will be assessed using the Tyrer-Cuzick breast cancer risk model. Participants will be referred to appropriate clinics if lifetime risk is greater than 20 percent.
Time frame: Yearly follow up for 10 years
Assess 5- year breast cancer risk through the GAIL breast risk evaluation tool
Participants' breast cancer risk will be assessed using the National Cancer Institute's GAIL model. Participants will be referred to appropriate clinics if GAIL 5 year risk is greater than 1.7 percent.
Time frame: Yearly follow up for 10 years
Early detection of malignancies through screening
Participants will be educated on screening recommendations by the American Cancer Society. Malignancies will be recorded yearly if found by recommended screenings.
Time frame: Yearly follow up for 10 years
Assess changes in fat mass by SOZO measurements
Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure fat mass.
Time frame: Yearly follow up for 10 years
Assess changes in muscle mass by SOZO measurements
Body composition will be assessed yearly by measurements taken from the SOZO device which uses bioimpedance spectroscopy to measure muscle mass.
Time frame: Yearly follow up for 10 years
Assess changes in quality of life by the 5-level EuroQol-5D version (EQ-5D-5L) questionnaire
Quality of life will be assessed yearly by the EQ-5D-5L questionnaire. Participants' will self-report their health on a scale numbered 0-100. 100 means the best health you can imagine and 0 means the worst health you can imagine.
Time frame: Yearly follow up for 10 years
Plan to share: Yes — De-identified data sets will be available upon requests following institutional approval.
Supporting information: Study protocol, Informed consent form, Clinical study report
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
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Prisma Health-Upstate